Which exercise is best for your heart? new study aims to find out
NCT ID NCT06788275
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how different types of aerobic exercise affect blood vessel health in people with ischemic heart disease (such as after a heart attack or angina). Researchers will compare high-intensity interval training with short bursts, long bursts, and moderate-intensity training. 132 men and women aged 45-75 will exercise three times a week for 12 weeks to see which method works best.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 132 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2024
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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A research network
The lead sponsor is a research network or cooperative group.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Men and women aged between 45 and 75 years. * Diagnosed with acute myocardial infarction, unstable or stable angina. * Treated with percutaneous coronary intervention, coronary artery bypass grafting, or conservative treatment. * Event or intervention within 3 to 12 months prior to participation in the study. * Fluency in speaking and reading Spanish. * Residing in Elche or surrounding areas and able to attend evaluations and the exercise programme (not planning to be absent for more than one week during the programme). * Functional Class I-II according to the New York Heart Association (NYHA) classification. * No physical limitations for exercise. * Stable optimal medical treatment. * Physically inactive, defined as 1) not meeting the World Health Organization recommendations for both aerobic and strength exercise, and 2) not participating in a structured exercise programme at least 3 days per week for more than 3 months. Both conditions must be met for inclusion. Note: Casual walking is not considered grounds for exclusion. Exclusion Criteria: * Use of walking assistive devices. * Treatment with chemotherapy for any type of cancer in the past 2 years. * Hospitalisation in an intensive care unit in the past 6 months for reasons other than the ischaemic event. * Acute myocardial infarction group IV Killip-Kimball. * Obesity grade III (≥40.0 kg/m²). * Medical contraindication for inclusion in an exercise programme. * Diabetes with uncontrolled blood glucose levels. * Poorly controlled hypertension: resting blood pressure \> 180/110 mmHg. * Chest pain with exertion or ST-segment changes suggestive of residual ischemia during ergometry. Residual ischemia. * Severely reduced functional capacity on initial ergometry (\<5 metabolic equivalent of task). * Left ventricular ejection fraction less than 50%. * Severe stenosis of the left main coronary artery (\>50% significant disease). * Severe aortic stenosis, left ventricular outflow tract obstruction (e.g., obstructive hypertrophic cardiomyopathy) or aortic dissection. * Severe valvulopathy. * Acute pulmonary embolism or deep vein thrombosis. * Severe pulmonary hypertension. * Acute heart failure. * Acute endocarditis, myocarditis, or pericarditis. * Acute or chronic renal insufficiency (estimated glomerular filtration rate \<30 ml/min). * Pulmonary fibrosis or interstitial disease (severe respiratory insufficiency or confirmed chronic obstructive pulmonary disease). * Uncontrolled cardiac arrhythmias/hemodynamically unstable. * Permanent or persistent/paroxysmal atrial fibrillation with episodes in the past 6 months. * High-grade cardiac block. * Presence of implantable devices: cardiac resynchronization therapy pacemaker, implantable cardioverter defibrillators, or pacemaker. * Presence of ischaemic symptoms during the incremental exercise test performed before the intervention. * Severe autonomic or peripheral neuropathy. * Use of nitrates in pharmacological treatment. * Any planned surgical or medical intervention during the study period. * Plans to participate in or current participation in other studies that may interfere with this study. * Current pregnancy or intention to become pregnant during the study period.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Centro de Investigación del deporte
RECRUITINGElche, Alicante, 03202, Spain
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Instituto de Investigación Sanitaria y Biomédica de Alicante
RECRUITINGAlicante, Alicante, 03010, Spain
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