Xuanwu Hospital, Beijing

This pilot study tests whether everolimus, a drug usually used for cancer, can help control seizures in people with drug-resistant focal epilepsy. Only 5 adults aged 18-60 will take the drug during seizure events for 12 weeks. The goal is to see if seizure frequency drops and if …

This early study tests whether adding daily near-infrared light therapy to the drug lecanemab can improve thinking and memory in people with mild Alzheimer's disease. Twenty participants will receive either real or sham light therapy plus lecanemab for 16 weeks, then all will get…

This study tests whether everolimus, an oral drug already used for some cancers, can help adults with vascular malformations (abnormal blood vessels). Ten participants will take the drug daily for a year, and researchers will use MRI scans to see if the malformations shrink or im…

This study tests whether performing skull surgery early, before dangerous brain swelling occurs, can improve outcomes for people who have had a severe stroke and are at high risk of swelling. About 380 adults aged 18–75 will be randomly assigned to receive either early surgery pl…

This study tests whether using a balloon guide catheter during a stroke procedure helps restore blood flow more effectively than standard methods. Researchers will compare the two approaches in 364 adults with acute ischemic stroke caused by a blocked internal carotid artery. The…

This study is testing whether a ketogenic diet (a high-fat, low-carbohydrate diet) can help stop super-refractory status epilepticus—a life-threatening condition where seizures continue despite standard medications. The diet is given via feeding tube or by mouth to 84 ICU patient…

This study tests whether adding batroxobin, a snake venom enzyme that dissolves clots, to standard blood thinners helps people with acute cerebral venous thrombosis (a rare stroke caused by a clot in a brain vein). Seventy-two adults will be randomly assigned to receive either st…

This early-stage trial is testing whether a nasal spray containing exosomes from umbilical cord stem cells is safe and might help people with mild to moderate Alzheimer's. The study involves 33 participants and will first test different doses, then compare the best dose to a plac…

This study looks at how well a device called WEB works for treating brain aneurysms (weak spots in blood vessels) in real-life medical practice. It will include 1,000 people of any age who have had this device placed. The main goals are to see if the aneurysm is sealed off at 12 …

This study tests whether a newer clot-dissolving drug (tenecteplase) works better than the standard drug (alteplase) when given before a mechanical procedure to remove a large blood clot from the brain. About 850 adults who have had a severe stroke within the last 4.5 hours will …

This study compares standard medical care to a new, less invasive surgery for people with a severe bleeding stroke. The surgery uses a small tube to drain the blood clot and delivers clot-busting medicine directly into the brain. Researchers want to see if this approach helps pat…

This study tests whether adding a drug called GM1 to standard clot-removal treatment helps people recover more fully after a severe stroke. About 868 adults with large-vessel blockage in the front part of the brain will receive either GM1 or a placebo alongside their emergency pr…

This study looks at whether giving a clot-dissolving drug called Tenecteplase to stroke patients before they are moved to a hospital that can perform a clot-removal procedure improves their recovery. The trial involves 572 adults who had a stroke caused by a large blockage in the…

This study looks at whether a structured rehabilitation program can delay or reduce the chance of spine degeneration near the surgery site in frail adults aged 75 and older who have had short-segment lumbar fusion. About 212 participants will be randomly assigned to either the re…

This study tests a new treatment made from stem cell exosomes (tiny particles) given through an IV to people who recently had a stroke. The goal is to see if it is safe and helps the brain recover. About 29 adults aged 18-70 with moderate to severe stroke will take part. The trea…

This study tests whether giving a clot-busting drug (tenecteplase) before transferring patients with a severe stroke in the back of the brain (basilar artery occlusion) to a specialized hospital can improve recovery. About 316 adults who had a stroke 4.5 to 24 hours earlier will …

This study looks at whether a special type of CT scan (multimodal CT) can more accurately identify the blocked artery in people having a medium vessel occlusion stroke. Researchers will compare the accuracy of multimodal CT against standard CT scans in 622 participants. The goal …

This study aims to improve early detection of Alzheimer's disease in adults aged 50 and older who have no memory complaints. Participants will first complete a quick digital screening (questionnaire and cognitive test), and those at risk will have blood tests to confirm Alzheimer…

This study is testing a new blood test to help doctors diagnose Parkinson's disease and similar brain disorders more accurately and earlier. Researchers will use a technique called RT-QuIC to detect misfolded proteins in blood samples from 458 participants, including healthy peop…

This study tests whether a device that sends mild electrical currents to the brain (hi-tACS) can improve sleep in people with neuroimmune diseases like multiple sclerosis or neuromyelitis optica who also have insomnia. Eighty participants will receive 20 sessions of the stimulati…

This study compares two painkillers given through a patient-controlled pump after brain surgery. The goal is to see if oliceridine causes less nausea than the standard drug sufentanil. 174 adults having surgery near the cerebellopontine angle will be randomly assigned to one of t…

This study tests whether a 60-second ultrasound pulse to a specific brain region can improve thinking and memory in people with long COVID brain fog. Forty participants will receive either real or fake (sham) stimulation. The goal is to see if this safe, non-invasive technique ca…

This early-stage trial tests whether injecting tiny particles from stem cells into the spinal fluid can safely improve symptoms in people with syringomyelia, a condition where fluid-filled cavities form in the spinal cord. The study involves 18 adults whose spinal cavities have s…

This small early-phase study is testing whether galcanezumab, a drug used for migraines, can help people with mild-to-moderate Alzheimer's disease. Ten participants will receive injections over 24 weeks, and researchers will measure changes in thinking, memory, and brain chemical…

This study tests whether a common painkiller (oxycodone with acetaminophen) can safely ease moderate to severe chronic pain in people with Alzheimer's disease. Ten participants will take the medication daily for 12 weeks, with doctors adjusting the dose as needed. The goal is to …

This study tests a 6-week pre-surgery program for people aged 75 and older who need spine surgery. The program includes exercise, nutrition advice, managing other health conditions, and brain training. Researchers want to see if it helps patients become more independent after sur…

This study looks at whether giving clot-busting drugs to stroke patients up to 24 hours after symptoms start is safe and effective. Researchers will review medical records of 2,600 people who received this treatment outside the standard 4.5-hour window. The goal is to see if thes…

This study aims to measure the financial and emotional burden of Alzheimer's disease on patients and their families in China. Researchers will track nearly 10,000 participants to understand medical costs, caregiving expenses, and quality of life. The goal is to fill gaps in knowl…

This study tracks 500 people who had surgery for a brain hemorrhage. Researchers will compare different surgical methods—like endoscopic surgery or minimally invasive techniques—to see which leads to better recovery and quality of life. The goal is to gather real-world data to gu…

This study is a large registry that will collect data from over 10,000 people in China diagnosed with a rare condition where abnormal connections form between arteries and veins in the brain or spine. Researchers will track how common the disease is, what treatments are used, and…

This study follows 10,000 patients who had a bleeding aneurysm in the brain to learn more about a complication called delayed ischemic neurological deficit (DIND). Researchers will track how doctors diagnose and treat DIND, and compare different treatment approaches to see which …

This study uses special PET/MR scans to measure blood flow and sugar use in the brains of 200 people with severely narrowed neck arteries. The goal is to find better ways to diagnose and treat these patients, who have already had a mini-stroke or stroke. Participants will be foll…

This study is testing a new, noninvasive MRI technique to see if it can better predict stroke risk in people with narrowed arteries in the brain (ICAS). Researchers will measure blood flow pressure using a special MRI scan and follow 400 participants for one year to see who has a…