Uppsala University

This study is testing if a pill called pivmecillinam works as well as standard treatments for serious urinary tract infections that cause fever. It involves 560 adults who are already in the hospital and have started to improve after a few days of antibiotics given through an IV.…

This study aims to find out if spinal fusion surgery actually helps people with chronic low back pain, or if the benefits come from the placebo effect of just having surgery. 90 patients with long-term, severe back pain will be randomly assigned during their operation to either r…

This study aims to find out if wearing a sling (non-surgical treatment) works as well as having an operation for a specific type of broken outer collarbone. Adults aged 18-65 with this injury will be randomly assigned to receive either treatment. The main goal is to see which gro…

This study is testing a special suction dressing (Negative Pressure Wound Therapy) to see if it helps prevent wound problems after emergency abdominal surgery. Researchers will compare it against regular dressings in 720 adults. The goal is to reduce infections, wound openings, f…

This study aims to find the best treatment for advanced pancreatic neuroendocrine tumors (NETs) that have spread. It will compare two approaches: one group receives near-total surgical removal of the tumor plus standard drug treatments, while the other receives drug treatments al…

This large international study is testing whether a shorter, 6-month course of immunotherapy after surgery is just as effective as the current standard 12-month course for patients with high-risk melanoma. The goal is to see if the shorter treatment can prevent the cancer from re…

This study is testing whether a 10-week group therapy program is practical, acceptable, and helpful for reducing anxiety and depression in autistic teenagers aged 15-18. Researchers will work with 36 participants to see if the therapy is easy to run, if teens find it useful, and …

This study is testing two different ways to manage pain in children aged 1 to 15 after they have open abdominal surgery. Researchers want to see which method—a single nerve block injection or a continuous drip of numbing medicine—works better to control pain and reduce the need f…

This international study aims to understand how often children develop sudden kidney problems after non-heart surgery. Researchers will observe 2,000 hospitalized children aged 0-16 to measure the rate of this injury and identify what factors increase the risk. They will also tes…

This study aims to understand why some critically ill patients develop sudden kidney damage, especially after severe infections or major surgery. Researchers will measure inflammation markers in blood, urine, and sputum from 100 ICU patients with sepsis, recent surgery, or chemic…

This large observational study aims to see if using a robotic system helps surgeons place screws more accurately during spine surgery compared to traditional methods. It will follow thousands of patients for up to two years to compare how often screws are misplaced, how long surg…

This study aims to learn if measuring a patient's extracellular water (fluid outside their cells) can help doctors better understand unstable blood pressure in sepsis. Researchers will enroll 20 adult sepsis patients in intensive care and add this special water measurement to the…

This study aims to understand how what we eat affects how we sleep and our body's daily functions. Healthy young adults will try two different diets—one unhealthy 'Western' style and one healthier, fiber-rich diet—while researchers measure their sleep, heart rate, blood sugar, an…

This study aims to understand how different patients with a serious heart infection (infective endocarditis) process common antibiotics. Researchers will collect blood samples from 150 patients in Sweden to measure drug levels and see how factors like age and kidney function affe…

This study aims to find signs in the blood that show if brain cancer treatments are causing injury to a child's brain. Researchers will follow 560 children with brain tumors and healthy kids, taking blood samples over three years to compare those who get radiation, chemotherapy, …