Could a simple pill replace IV antibiotics for kidney infections?

NCT ID NCT07236944

Recruiting now Disease control Sponsor: Uppsala University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether pivmecillinam pills work as well as standard antibiotics for treating febrile urinary tract infections (kidney infections) in adults. Participants who have already improved after 2-4 days of IV antibiotics will take pivmecillinam or continue standard care. The goal is to see if the oral option is just as effective at clearing the infection and preventing relapse.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pivmecillinam (an antibiotic pill)
What this could lead to: If it works, this could offer a simpler, oral option for treating serious kidney infections after initial IV antibiotics, reducing hospital stays.
What could go wrong: This is a phase 4 trial, so the drug is already approved, but it may not be as effective as standard care for all patients. Side effects or antibiotic resistance could also limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

escherichia coli infection urinary tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FEBRILE URINARY TRACT INFECTION

Contacts and locations

Locations

Blekinge Hospital
NOT_YET_RECRUITING

Karlskrona, Sweden
Central Hospital Växjö
NOT_YET_RECRUITING

Vaxjo, Sweden
Eskilstuna Hospital
NOT_YET_RECRUITING

Eskilstuna, Sweden
Haukeland University Hospital
NOT_YET_RECRUITING

Haukeland, Norway
Karolinska University Hospital
NOT_YET_RECRUITING

Stockholm, Sweden
Oslo University Hospital
NOT_YET_RECRUITING

Oslo, Norway
Sahlgrenska University Hospital
RECRUITING

Gothenburg, Sweden
Skåne University Hospital
NOT_YET_RECRUITING

Lund, Sweden
Sundsvall Hospital
NOT_YET_RECRUITING

Sundsvall, Sweden
Södra Älvsborg Hospital
NOT_YET_RECRUITING

Borås, Sweden
Umeå University Hospital
NOT_YET_RECRUITING

Umeå, Sweden
Uppsala University Hospital
RECRUITING

Uppsala, Sweden
Örebro University Hospital
RECRUITING

Örebro, Sweden