University Of North Carolina, Chapel Hill

This study tests different telehealth weight loss programs for adults aged 65-85 who have obesity and at least two chronic health conditions. The goal is to find the best first step and how to help those who don't lose enough weight. Participants will be randomly assigned to diff…

This study tests two different surgical techniques for people who need repeat eyelid surgery for trichiasis, a condition where eyelashes grow inward and scratch the eye. About 1,000 adults in Tanzania will receive either the standard procedure or a newer method called B-RAP. The …

This study tests a drug called finerenone in people who have received a kidney transplant. The goal is to see if it can help protect the new kidney and reduce complications. About 100 adults who are 1 to 10 years post-transplant will take either finerenone or a placebo. Researche…

This study tests whether providing medically tailored meals along with intensive lifestyle coaching helps adults with HIV and type 2 diabetes (or high risk for it) better manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the m…

This study tests whether adding a continuous glucose monitor (CGM) and nutrition counseling to a food assistance program helps adults with type 2 diabetes and food insecurity better manage their blood sugar. About 60 participants will be split into two groups: one gets the standa…

This study tests whether a fast-acting sublingual medication (TNX-102 SL) can reduce acute stress symptoms and prevent long-term PTSD in adults who have been in a car accident. 180 participants will receive the drug or a placebo in the emergency room and take it for two weeks at …

This study tests a mobile health app called Bolster for caregivers of young adults (ages 15-30) who have early psychosis. The goal is to see if the app can reduce caregiver distress and improve family communication. About 30 caregivers in North Carolina will use the app and repor…

This study tests two numbing medicines for wrist fracture surgery: standard bupivacaine and a longer-acting version (Exparel). About 100 adults will receive one of the two drugs as a nerve block before surgery. Researchers will track pain levels and recovery quality for 48 hours …

This study tests whether a 3-D brain imaging technique can make focused ultrasound more precise for treating essential tremor. About 24 people with moderate to severe tremor that hasn't responded to medication will receive the procedure. The goal is to reduce tremor and check for…

This study tests if a single session combining non-invasive brain stimulation and psychotherapy can safely and quickly ease symptoms in people with treatment-resistant depression. Researchers will enroll 30 adults aged 18-70 with major depressive disorder. Participants receive th…

This study explores whether teachers can be trained to provide mental health care to teenagers in rural India. About 216 students aged 13-17 from low-cost private schools will participate. The goal is to see if this approach is practical and helps reduce emotional and behavioral …

This study looks at whether giving estradiol (a form of estrogen) can help perimenopausal women who started having depression, psychosis, or loss of pleasure during this life stage. About 100 women aged 44-55 will receive either estradiol or a placebo, and researchers will use br…

This study compares two virtual group programs—one focused on emotions, the other on problem-solving—to help adults with type 1 diabetes feel less distressed about their condition. About 200 participants aged 30 and older with elevated diabetes distress will join weekly online se…

This study tests whether a telehealth program called REAL-Fam can help rural families better manage a child's type 1 diabetes and improve family quality of life. About 16 families will either receive 12 video sessions with REAL-Fam or 3 basic Zoom meetings. The main goal is to se…

This study tests whether taking a daily omega-3 supplement called SPM Active® for 12 weeks can increase certain healthy fats in the blood and improve feelings of burnout, life satisfaction, and sleep quality. Researchers will enroll 33 adults aged 45-60 with obesity (BMI 30-40). …

This study tests whether virtual family navigation helps toddlers under 4 in rural North Carolina start autism therapy sooner after diagnosis. Families get 4 online sessions with a trained navigator to find and enroll in services. Researchers compare their progress to families wh…

This study looks at whether taking a special protein powder every day for 4 weeks can improve blood sugar control and overall well-being in healthy women aged 30 to 60. Researchers will measure blood sugar responses after meals, insulin sensitivity, and body composition. The goal…

This study looks at how natural hormone changes during the menstrual cycle affect mood and pleasure in women whose depression worsens before their period. Researchers will give 75 women either hormones or a placebo to see if stabilizing hormone levels helps. The goal is to unders…

This study aims to understand how different colors of light can change pain perception by looking at brain activity. Researchers will use MRI scans to compare brain responses in 60 people—half with chronic muscle or fibromyalgia pain and half healthy volunteers. Participants will…

This study looks at how spinal cord stimulation (SCS) can create artificial sensations in people with chronic pain. Researchers will test how changing the stimulation affects what people feel. The goal is to better understand how SCS works, not to treat pain directly. About 10 ad…

This study looks at how breathing in woodsmoke changes the way your nose's immune system reacts to the flu virus. Healthy adults aged 18-49 will be exposed to woodsmoke and then given a live but weakened flu vaccine to mimic infection. Researchers will measure immune markers and …

This study looks at how sex hormones during puberty may affect mood differently in boys and girls. Researchers will track depressive symptoms in 60 teens aged 11-14 using a smartphone app. The goal is to understand why depression rates rise in girls during puberty, not to test a …

This study looks at how the brain talks to muscles in people who have had a stroke. Researchers will use a safe, non-invasive technique to stimulate different parts of the brain while participants squeeze a device with their weak hand. The goal is to see if this stimulation impro…

This study looks at how personality traits and stress hormones influence decision-making in people with borderline personality disorder (BPD). Researchers will compare 106 adults aged 18–45 with and without BPD using online tasks, stress tests, and heart monitoring. The goal is t…

This study is testing whether a nutritional supplement called beta-hydroxy-methylbutyrate can help older adults (ages 65-85) improve their physical function, like strength and walking speed. The main goal is to see if the study procedures are practical and acceptable to participa…

This study looks at ways to better support parents whose children have hypospadias, a common birth condition affecting the penis. About 324 parent-child pairs will be split into groups and followed for at least 6 months. Researchers will measure how well different support methods…

This study looks at whether easy-to-do tests for frailty and muscle strength can help predict which adults aged 65 and older are more likely to have problems after major abdominal surgery. About 100 participants will take brief tests during a regular pre-surgery visit and be foll…

This study looks at whether warning labels on sugary drinks affect people's beliefs about weight. Over 500 adults will shop in a mock store and answer surveys about their views on obesity. The goal is to understand if these labels, meant to promote health, might accidentally incr…

This study tests whether banning menthol cigarettes, along with a quit-smoking campaign, changes what people buy. About 1,185 adults who smoke menthol cigarettes will be followed to see if they stop buying tobacco or switch to other products. The goal is to understand how such a …

This study looks at whether moving the knee joint in a specific way (called manipulation) can improve how fast the brain and muscles react in people who have had ACL surgery. Researchers will work with 30 volunteers aged 18-35 who are 4 months to 10 years past their surgery. Part…