Thomas Jefferson University

This study tests a two-step approach using lower doses of radiation and chemotherapy before a stem cell transplant for people with various blood cancers. The goal is to see if this gentler preparation reduces the risk of death from the treatment itself. About 63 participants will…

This study tests whether placing a stitch (cerclage) in the cervix can lower the chance of preterm birth in pregnant people with a short cervix (≤25mm) detected between 24-26 weeks. About 329 participants will be randomly assigned to receive the stitch or standard care. The main …

This study tests a drug called tebentafusp in 19 people with a rare eye cancer (uveal melanoma) that is too large to remove without taking the whole eye. The goal is to see if the drug can shrink the tumor by at least 20% so that less invasive surgery might be possible. Participa…

This early-phase trial tests whether using ultrasound and microbubbles can help the immunotherapy drug pembrolizumab reach tumors better in people with recurrent or metastatic head and neck cancer. Only 6 participants will be enrolled to see if the approach is feasible and safe. …

This study looks at whether placing a small tube (stent) in the ureter after bladder removal surgery increases or decreases the risk of urinary tract infections. About 70 adults with bladder or pelvic cancer will be randomly assigned to get a stent or not. The goal is to find out…

This early-stage trial tests a two-step vaccine strategy in 18 adults with advanced colorectal or small bowel cancer that has stopped responding to standard treatments. The first vaccine primes the immune system, and the second boosts it to target cancer cells. The main goal is t…

This early-phase study tests two new drug combinations for people whose acute myeloid leukemia (AML) has come back or not responded to prior treatment. In Part 1, participants receive tazemetostat plus standard chemotherapy (CPX-351). In Part 2, they get a pre-treatment drug (pal…

This study tests whether high-dose radiotherapy can reduce painful lumps and abscesses in people with moderate to severe hidradenitis suppurativa (HS) that hasn't responded to other treatments. Ten adults with HS in both armpits will receive radiotherapy to one armpit while the o…

This study tests whether giving iron through a vein (IV) early in the second trimester works better than standard iron pills for treating iron deficiency anemia in pregnancy. About 80 pregnant women with mild anemia will be randomly assigned to one of the two treatments. The goal…

This study tests a new approach to collecting stem cells for people with multiple myeloma, Hodgkin lymphoma, or non-Hodgkin lymphoma who need a stem cell transplant. The goal is to see if using a standard drug alone, and adding another drug only when needed, can collect enough st…

This study tests a drug called tebentafusp combined with treatments that target liver tumors directly (like embolization or chemo-embolization) in people with a specific type of eye cancer (uveal melanoma) that has spread to the liver. The goal is to see if the combination is saf…

This early-phase study tests an experimental daily pill, VK-2019, in 30 adults with a rare type of lymphoma (EBV-positive DLBCL) that has come back or not responded to at least two prior treatments. The main goal is to find the safest dose by giving three different dose levels ov…

This study looks at whether cutting calories while getting focused radiation (SABR) before surgery can shrink breast tumors more than radiation alone. About 80 adults with early-stage breast cancer will be randomly assigned to one of two groups. The goal is to see if the diet hel…

This study explores whether women can accurately collect their own samples for HPV testing, which could make cervical cancer screening easier and more accessible. The research focuses on minority women who are often under-screened, using community health workers to help with the …

This study is testing a new way to detect prostate cancer by looking at cells in urine using special imaging. Researchers will collect urine samples from 675 men aged 50-75, some with prostate cancer and some without, to see how accurate the test is. The goal is to find a non-inv…

This study tests whether a self-help version of Acceptance and Commitment Therapy (ACT), delivered via smartphone, can reduce anxiety and depression in adults with cystic fibrosis (CF). 60 participants with CF and mild mood symptoms will use the toolkit and be monitored for chang…

This study tests whether giving blood transfusions at home is practical and acceptable for cancer patients who need regular transfusions. About 30 adults with blood cancers or bone marrow failure will receive 1-5 blood product units at home. Researchers will track how often trans…

This study tests a combination of two non-invasive treatments—spinal cord stimulation and special breathing exercises—to improve breathing in people with chronic spinal cord injury. Researchers aim to strengthen the muscles used for breathing and identify biomarkers to predict wh…

This study tests whether taking two common pain relievers (acetaminophen and NSAIDs) at different times works better than taking them together after a cesarean delivery. About 825 women who have a C-section will be randomly assigned to one of the two schedules. The goal is to fin…

This pilot study enrolls 45 adults who take opioids daily and are scheduled for spine surgery at least four weeks away. Participants are randomly assigned to receive either opioid tapering education alone or education plus cognitive behavioral therapy (CBT). The goal is to see if…

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking skills in breast cancer survivors from diverse racial backgrounds. Researchers will enroll 30 women aged 40 and older who are at least five years past diagnosis. Participants co…

This study looks at why some cancer patients who have social needs—like trouble getting food, housing, or transportation—choose not to accept help from their cancer center. Researchers will survey 500 adults and interview a smaller group to understand their reasons. The goal is t…

This study watches 20 adults in cardiogenic shock who need a temporary heart pump (IABC). Researchers want to see if the stiffness of the arteries changes how well the pump works. They will measure blood flow and other vital signs before, during, and after the pump is used. The g…

This study is a worldwide registry that collects information from people with a rare spinal blood vessel condition called spinal dural arteriovenous fistula. The goal is to gather enough data to better understand the disease and improve future treatments. Participants must have b…

This study looks at whether wearing a continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes track their blood sugar better than the standard finger-stick method. About 70 participants will be randomly assigned to either test their blood sugar four times a day…

This study looks at how to help cancer patients from low-income and low-literacy backgrounds take their oral chemotherapy medications as prescribed. Researchers will test different support strategies and track how often doses are missed. The goal is to find practical ways to impr…

This study looks at whether a network of peer genetic coaches can help African American men with metastatic prostate cancer overcome barriers to genetic testing. The coaches will provide support and navigation to increase awareness and access. The study involves 30 participants a…

This study explores whether virtual reality and 3D models can help surgeons plan head and neck cancer operations more accurately. About 160 adults with head and neck cancer will take part. The goal is to see if this technology reduces the chance of leftover cancer cells and impro…

This study collects leftover tumor tissue and a one-time blood sample from 200 adults with breast cancer or precancerous breast conditions. Researchers will analyze the samples to identify cancer biomarkers and understand how genes interact with tumors. Participants do not receiv…

This early study tests whether contrast-enhanced ultrasound (CEUS) can help doctors see how soft tissue sarcoma responds to radiation therapy given before surgery. Ten adults with sarcoma will get CEUS scans at three points during treatment. The goal is to see if combining ultras…

This study is for people with lung or esophageal cancer who will receive radiation therapy. Sometimes the heart gets exposed to radiation during treatment, which may change how it works. Researchers want to see if special PET/CT scans can detect these changes by scanning the hear…

This study looks at whether a special type of ultrasound (contrast-enhanced ultrasound) can better detect if liver cancer is still alive after a treatment called radioembolization. Standard CT or MRI scans can take months to show if the treatment worked, which can delay next step…

This study aims to find the genetic causes of nonimmune hydrops fetalis, a serious condition where abnormal fluid builds up in a fetus. Researchers will use whole exome and whole genome sequencing on samples from 55 families when standard tests are negative. The goal is to identi…

This study looks at whether having a trained peer navigator—someone who guides patients through the process—helps African American men with advanced prostate cancer better understand and complete genetic testing. Genetic testing is important for treatment decisions, but many pati…

This study looks at how social factors like stress and support relate to inflammation in women newly diagnosed with breast cancer. About 200 participants will fill out questionnaires and give one blood sample. The goal is to understand these links, not to provide treatment.

This study looks at two different ways surgeons cut blood vessels during lung cancer surgery. The goal is to see if tying off the vein first (instead of the artery) reduces the amount of tumor DNA released into the bloodstream. About 100 adults with early-stage lung cancer will h…