Radboud University Medical Center

This early-stage trial tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The vaccine uses a virus-like particle to train the immune system, and some doses included an adjuvant to boost response. The main goals were to check safety and m…

This trial tests whether a structured medication review and care coordination (TMPC) can reduce drug-related hospital readmissions in adults aged 70 and older who take five or more regular medications. Participants receive a detailed medication analysis, discussions among hospita…

This Phase 2 trial tested whether adding interferon-gamma to standard antifungal treatment helps clear Candida from the blood faster. 65 adults with candidemia received the drug or standard care alone. The study is completed, and results will show if this combination is safe and …

This study looked at whether a special needle device (vacuum-assisted biopsy) can completely remove small breast cancers using ultrasound guidance, instead of traditional surgery. 45 women with small, early-stage breast cancers participated. The goal was to see if this less invas…

This study tested whether psoriasis patients who are stable on biologic drugs (IL17 or IL23 inhibitors) can safely reduce their dose without their skin condition getting worse. Researchers enrolled 244 adults with plaque psoriasis who had been on a normal dose for at least 6 mont…

This phase 2 trial tested a drug called Lutetium-177-PSMA-617, which delivers radiation directly to prostate cancer cells. It included 58 men with prostate cancer that had spread to a few spots in bones or lymph nodes but was still hormone-sensitive. The study compared the drug t…

This study tested a monoclonal antibody called TB31F in 167 adults and children in Mali who are regularly exposed to malaria. The goal was to see if the antibody is safe and can reduce the spread of the malaria parasite from humans to mosquitoes. Participants received either the …

This phase 2 trial tested two immunotherapy drugs, ipilimumab and nivolumab, in 69 men with a specific type of advanced prostate cancer that no longer responds to hormone therapy. The goal was to see if the combination could shrink tumors or slow disease progression. Participants…

This study tested a new way of giving radiation to people with head and neck cancer. The goal was to lower the radiation dose to healthy neck areas to reduce side effects like trouble eating, while still keeping the cancer from coming back. About 300 patients took part, and the r…

This study tested a new laser-based device (AccuMeasure) to measure the size of colon polyps during a colonoscopy. Accurate polyp size is important because it helps doctors decide how often patients need follow-up screenings to prevent colorectal cancer. The study involved 138 ad…

This study tested a special brace (STIL Orthosis) designed to reduce shaking (tremor) in people with Parkinson's disease. 25 participants had their tremor measured while wearing the active brace, a fake brace, and no brace. The goal was to see if the device could make everyday ta…

This study tested a psychological intervention to help people with Parkinson's disease who experience freezing of gait triggered by anxiety. 41 participants learned strategies to manage stress and attention while walking. The goal was to see if this approach could reduce the time…

This study tested a program where home-care nurses were trained to support people with dementia in making their own everyday choices, with help from family caregivers. 12 people with dementia, 14 caregivers, and 33 nurses took part. Most found it helpful, but the program was time…

This study looked at whether placing a bone-anchored hearing implant in a single surgery is as safe as the traditional two-step approach in children aged 4 to 9. The single-stage method is already standard in adults, but many surgeons still use two surgeries for kids. The main qu…

This study looked at whether protein supplements or dietary advice could reduce muscle damage in active older adults after long-distance walking. 199 participants aged 60+ used whey protein, plant-based protein, or protein-rich foods for 5 weeks, and walked 30-50 km. Researchers …

This study tracked 241 ICU patients with severe influenza to see how many developed a fungal lung infection called IAPA. Researchers collected blood and fluid samples to identify risk factors. The goal is to help doctors spot high-risk patients earlier.

This study looked at how five common HIV drugs enter breast milk in 20 healthy women who were finishing breastfeeding. The goal was to find out if the drug levels could be too high (risking infant side effects) or too low (risking drug resistance if the baby gets HIV). Participan…

This study tested two non-invasive monitors that track pain in children aged 1-12 during surgery. The monitors measure skin conductance and a pain index to see how well they detect pain events. Researchers compared their readings to find which one is more reliable for guiding pai…

This study tested a tool called KomPas+ that helps therapists and patients with leg pain from blocked arteries (intermittent claudication) make shared decisions about treatment. Over 2,200 participants used the tool to see if it improved walking distance and quality of life. The …

This completed study examined how immune cells (myeloid cells and their bone marrow progenitors) change in patients with newly diagnosed thyroid or colon cancer. Researchers measured inflammatory markers before and after exposing cells to agents that could 'train' them to fight t…

This study looked at 16 mothers with HIV who chose to breastfeed while taking antiretroviral medication. Researchers measured drug levels in the mothers' blood and breastmilk, and in the babies' blood, to see how much medicine the infants received. The goal was to gather informat…

This study tested whether a computer model can help doctors give the right dose of anti-rejection drugs to children after a kidney transplant. The model used drug levels from blood samples to predict future exposure and guide dosing. 29 children participated, and the goal was to …

This study followed 51 adults who received a wider bone-anchored hearing implant (BIA300) to see how well it stayed in place and worked after 10 years. Researchers measured implant stability and checked for any skin or tissue problems. The goal was to see if the wider design is a…