Radboud University Medical Center

This early-stage study tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The main goals were to check if the vaccine was safe and to find the best dose that creates a strong immune response with minimal side effects. Volunteers received…

This study investigated whether patients with stable, mild psoriasis could safely reduce the dose of their advanced biologic medications (IL-17 or IL-23 inhibitors) without their symptoms getting worse. 244 patients who had been doing well on standard doses were randomly assigned…

This study tested a new type of targeted radiation treatment for men whose prostate cancer has spread to just a few places in the body but still responds to hormone therapy. It aimed to see if this treatment, which delivers radiation directly to cancer cells, could better control…

This study tested a computer-based method to personalize medication doses for children who had a kidney transplant. The goal was to better control the levels of two key anti-rejection drugs in the body. Doctors used the tool to recommend doses, then checked later to see if the pr…

This study tested whether children with certain types of hearing loss could get a bone-anchored hearing implant in just one surgery instead of two. It compared 22 children who had the new single-surgery procedure to about 50 children who previously had the standard two-surgery pr…

This study tested whether a combination of two immunotherapy drugs could help control advanced prostate cancer that had stopped responding to standard hormone treatments. The trial specifically enrolled 69 men whose cancers had certain genetic features that might make them more r…

This study tested a digital tool called KomPas+ designed to help physical therapists and their patients work together more effectively. The tool uses treatment guidelines to create personalized plans for people with leg pain caused by poor circulation (intermittent claudication).…

This study tested whether using lower radiation doses to healthy neck lymph nodes could reduce long-term side effects while still preventing cancer recurrence. It involved 300 adults with head and neck cancer who were scheduled for curative radiation treatment. Researchers compar…

This study tested a new laser measurement system to see if it can measure colon polyps more precisely than current visual estimation methods. Researchers compared the laser tool against traditional measurement approaches during routine colonoscopies in 138 polyps from adult patie…

This study tested a new lab-made antibody, called TB31F, in Mali to see if it could safely help stop the spread of malaria. Researchers gave the antibody to 167 adults and children who are regularly exposed to malaria to check for side effects and to measure how long it lasts in …

This study tested a special arm brace called the STIL Orthosis to see if it could reduce shaking (tremor) during everyday activities in people with Parkinson's disease. Twenty-five participants had their tremor measured while wearing the brace, wearing a dummy brace, and wearing …

This study tested whether different ways of adding more protein to your diet could help reduce muscle damage and soreness after long-distance walking in active older adults. For five weeks, 199 participants aged 60+ who were training for a multi-day walking event used either whey…

This study tested whether personalized mental strategies could help reduce walking freezes in people with Parkinson's disease, especially when those freezes are triggered by anxiety or stress. Forty-one participants who experienced daily anxiety-related freezing of gait received …

This study tested whether a nurse-led support program could help people with dementia living at home continue making their own daily decisions for as long as possible. The program trained nurses to focus on what people with dementia can still do, rather than taking over tasks too…

This study followed 51 adults for 10 years after they received a specific type of bone-anchored hearing implant. The goal was to see how stable the implant remained in the skull, how often it survived without problems, and how well the skin around it tolerated the device over a v…

This study aimed to understand how much HIV medication passes from a mother to her baby through breastmilk. Researchers measured drug levels in the blood and breastmilk of 16 mothers with HIV who chose to breastfeed while on treatment. The goal was to gather data to help make bre…

This study aimed to understand how the immune system's first responders (myeloid cells) behave in thyroid and colon cancer. Researchers tested if exposing these cells to certain substances could 'train' them to better fight tumors. The study involved 33 adults with newly diagnose…

This study aimed to test and compare two devices designed to measure pain in children during surgery while they are under general anesthesia. Researchers observed 50 children aged 1 to 12 years old to see how well the devices detected painful events and responded to pain medicati…