Radboud University Medical Center

This early-stage study tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The goal was to check the vaccine's safety and see how well it triggers the immune system. Researchers gave two doses, with or without an immune booster (adjuvant)…

This study tested whether people with stable psoriasis could safely reduce their dose of IL17 or IL23 inhibitor drugs without causing flare-ups. 244 adults with well-controlled psoriasis were randomly assigned to either dose reduction or standard care. The goal was to see if lowe…

This study tested a new antibody called TB31F in 167 adults and children in Mali who are often exposed to malaria. The goal was to see if the antibody is safe and can reduce the spread of the malaria parasite to mosquitoes. Participants received either the antibody or a placebo, …

This study looked at whether extra protein (from whey, plant-based protein, or protein-rich foods) can lessen muscle damage caused by long-distance walking in active adults aged 60 and older. 199 participants took one of three protein strategies or a carbohydrate drink for five w…

This study tested a new radiation treatment (177Lu-PSMA) in 58 men with prostate cancer that had spread to a few spots but was still hormone-sensitive. The treatment targets cancer cells specifically, aiming to delay disease progression compared to standard care. Results help det…

This study tested a combination of two immunotherapy drugs (ipilimumab and nivolumab) in 69 men with a specific type of advanced prostate cancer that no longer responds to hormone therapy. The goal was to see if the treatment could shrink tumors or stop the cancer from growing fo…

This study tested a special brace called the STIL Orthosis to see if it can reduce shaking (tremor) in people with Parkinson's disease. 25 participants had their tremor measured while wearing the active brace, a fake brace, and no brace. The goal was to find out if the device hel…

This study looked at whether a single surgery to place a bone-anchored hearing implant is as safe and effective as the usual two-step procedure in children aged 4 to 9. The main goal was to compare how often the implant was lost between the two approaches. The single-step method …

This study tested a support program for people with dementia living at home. Nurses were trained to focus on what the person still wants and can do, rather than taking over tasks. The program included home conversations with the person and their family caregiver to agree on what …

This study tested whether personalized strategies to reduce anxiety and stress around freezing of gait can help people with Parkinson's disease walk more easily. 41 participants completed the trial. The approach focused on managing mental state during walking to reduce freezing e…

This study tested a new way to give radiation therapy to people with head and neck cancer. The goal was to see if lowering the radiation dose to the neck (while still treating the main tumor) could reduce long-term side effects like trouble eating and improve quality of life. Abo…

This study tested a new laser-based measuring tool (AccuMeasure) to see if it can measure colon polyps more accurately than the usual visual estimate. Accurate polyp size is key for deciding how often patients need follow-up colonoscopies to catch cancer early. The study involved…

This study looked at how immune cells in the bone marrow change in people with thyroid or colon cancer. Researchers wanted to understand if these cells could be reprogrammed to fight tumors more effectively. The study involved 33 adults who were newly diagnosed and had not yet st…

This study looked at how much HIV medication passes from mother to baby through breastmilk. Sixteen mothers living with HIV who chose to breastfeed provided blood and milk samples at 1, 3, and 6 months after giving birth. Researchers measured drug levels to calculate how much med…

This study looked at how much of certain HIV medications get into breastmilk. Twenty healthy volunteers who were finishing breastfeeding took a single dose of one of the drugs. Researchers measured drug levels in blood and milk to understand the balance between safety for the bab…

This study looked at how well a wide-diameter bone-anchored hearing implant (BIA300) performed over 10 years in 51 adults. Researchers measured implant stability and survival, and checked for skin reactions. The goal was to understand the long-term safety and reliability of the d…

This study tested two devices that measure pain in children aged 1 to 12 during surgery. The goal was to see how well they detect pain signals. Fifty children took part, and the results help doctors choose better pain monitors for young patients.

This study tested a tool called KomPas+ that helps physical therapists and patients with intermittent claudication (leg pain from blocked arteries) make shared decisions about treatment. Over 2,200 participants used the tool to see if it improved walking distance and quality of l…

This study tested whether a computer model could help doctors give the right dose of anti-rejection drugs to children after a kidney transplant. 29 children took part, and their drug levels were measured to see how well the model predicted the best dose. The goal was to make trea…