Radboud University Medical Center

This study looks at whether taking extra protein every day and doing a supervised strength training session once a week can help people who have had weight-loss (bariatric) surgery keep their muscle mass. About 400 adults scheduled for surgery will be randomly assigned to either …

This study compares a higher dose (1800 mg) of the TB drug rifampicin to the standard dose in 164 adults with pulmonary tuberculosis. Researchers want to see if the higher dose causes more liver problems or other side effects, and whether it leads to better cure rates. Participan…

This early-phase trial tests a personalized vaccine made from a patient's own tumor cells. The vaccine is designed to train the immune system to recognize and attack ovarian cancer. The study involves 10 women with advanced ovarian cancer who will receive the vaccine alongside st…

This study tests a drug called obinutuzumab in 20 adults with a serious kidney condition called membranous nephropathy. The goal is to see how quickly the drug lowers harmful antibodies that attack the kidneys. Participants receive two infusions, with possible extra doses if need…

This study tests if levosimendan, a drug that strengthens heart and breathing muscles, can help critically ill patients get off a breathing machine faster. About 250 adults who have struggled to wean from ventilation will receive either the drug or a placebo. The goal is to see i…

This study is testing a new way to decide which parts of the neck need radiation treatment for head and neck cancer. Doctors will use a small biopsy to check lymph nodes, hoping to avoid radiating healthy areas. The goal is to control the cancer just as well as standard treatment…

This early-phase study tests a new imaging agent, TGW211, for people with HER2-positive cancers. The goal is to see if a special "trigger" can help clear the imaging tracer from healthy organs, making tumors easier to see on scans. About 19 adults will participate to check safety…

This study compares two ways to diagnose muscle-invasive bladder cancer: the standard procedure (TURBT) versus an MRI followed by a same-day biopsy. About 360 adults with suspected muscle-invasive bladder cancer will take part. The goal is to see if the MRI approach leads to fast…

This study tests whether atomoxetine, a medication that affects the brain chemical noradrenaline, can reduce freezing of gait in people with Parkinson's disease. Sixty participants will receive either atomoxetine or a placebo and will complete walking tests, MRI scans, and questi…

This study tests whether a smartphone app that helps people set personal goals for sleep, diet, exercise, and social connections can reduce depression symptoms. About 216 adults visiting their general practitioner for depression will either use the app alongside their usual care …

This study tests whether it's possible to run a larger trial comparing plant-based and animal-based nutritional drinks for hospital patients at risk of malnutrition. About 60 adults from two Dutch hospitals will be randomly assigned to receive either a soy-based or milk-based dri…

This study looks at how changing the pressure on a breathing machine (ventilator) affects the effort and efficiency of the diaphragm in patients with severe lung failure. Researchers will test six different pressure levels in 20 ICU adults to measure breathing drive, muscle activ…

This study looks at how the immune system reacts during and after sepsis in 400 ICU patients. Researchers will analyze blood samples to identify different immune response types, called immunotypes. The goal is to understand which responses help or harm patients, which could lead …

This study is testing a new computer model called ENDORISK that helps doctors predict whether early-stage endometrial cancer has spread to lymph nodes. About 735 patients will use the tool to guide treatment decisions, and researchers will compare results to standard care. The go…

This study looks at whether a special blood test can find tiny bits of cancer DNA left behind after prostate removal surgery in men with high-risk prostate cancer. The goal is to see if this test can better predict if the cancer will come back early. About 50 men will provide blo…

This study is looking at 1,000 people with heart artery disease who are getting a special, high-detail camera (OCT) inside their heart arteries during a routine procedure. Researchers want to see if the detailed pictures from this camera can predict future heart problems. They wi…