Smarter radiation for head & neck cancer: Biopsy-Guided treatment may spare patients from dry mouth
NCT ID NCT05333523
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial tests whether using a sentinel lymph node biopsy to guide radiation can safely reduce the amount of neck radiation in people with certain head and neck cancers. The goal is to lower long-term side effects like severe dry mouth while still controlling the cancer. About 242 adults with squamous cell carcinoma of the oropharynx, larynx, or hypopharynx will be randomly assigned to standard neck radiation or a personalized approach based on biopsy results.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Erasmus Medical Center
RECRUITINGRotterdam, Netherlands
Contact Email: •••••@•••••
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Leiden University Medical Center
RECRUITINGLeiden, Netherlands
Contact Email: •••••@•••••
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MAASTRO Clinic / Maastricht University Medical Center
RECRUITINGMaastricht, Netherlands
Contact Email: •••••@•••••
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Medisch Spectrum Twente (MST)
NOT_YET_RECRUITINGEnschede, Netherlands
Contact Email: •••••@•••••
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Radboud University Nijmegen Medical Center
RECRUITINGNijmegen, Netherlands
Contact Email: •••••@•••••
Contact Email: •••••@•••••
Contact
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Radiotherapiegroep / Rijnstate Ziekenhuis
NOT_YET_RECRUITINGArnhem, Netherlands
Contact Email: •••••@•••••
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The Netherlands Cancer Institute
RECRUITINGAmsterdam, Netherlands
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University Medical Center Groningen
RECRUITINGGroningen, Netherlands
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University Medical Center Utrecht
RECRUITINGUtrecht, Netherlands
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Other studies related to the condition(s) this trial covers.
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