Radboud University Medical Center

This study tests whether colchicine, an anti-inflammatory drug, can slow the progression of aortic valve stenosis—a common heart valve disease that currently has no medication. About 150 adults with moderate, symptom-free valve narrowing will take colchicine and be monitored with…

This study tests whether adding an immune-boosting drug called interferon-gamma 1b to standard antifungal treatment can help clear Candida bloodstream infections faster. About 200 adults with a confirmed Candida infection in their blood will receive either standard therapy alone …

This study tests whether a 12-month program focusing on stress, exercise, nutrition, sleep, and self-management can improve quality of life for people with Parkinson's disease. 256 participants will either work on their goals independently or with a lifestyle coach. The main outc…

This study tests whether a year-long mindfulness-based therapy can reduce stress, anxiety, and depression in 174 people with Parkinson's disease. Participants are randomly assigned to either the mindfulness program or their usual care. The goal is to see if lowering stress improv…

This study tests whether a smartphone app can help older adults increase their daily protein intake using regular foods. The goal is to preserve muscle mass and strength, which are key for healthy ageing. Researchers will enroll 140 participants who are comfortable using a smartp…

This study watches 350 ICU patients with severe influenza to see how often they develop a serious fungal lung infection called aspergillosis. Researchers aim to find out which patient traits or virus features raise the risk. The goal is to better understand and potentially preven…

This study looks at whether electroconvulsive therapy (ECT) or antidepressant medication is more cost-effective for treating severe major depression. Researchers will follow 220 adults in the Netherlands who have not gotten better with at least one antidepressant. The goal is to …

This study tests whether using personalized dosing (based on drug levels in the blood) helps more people with bacterial infections reach the right amount of teicoplanin compared to standard dosing. About 74 adults in hospital intensive care or other units will take part. The goal…