Radboud University Medical Center

This early-phase trial tests whether it is safe and possible to give people with advanced thyroid cancer a personalized mix of existing drugs chosen based on their tumor's genetic makeup. The study includes 10 patients who have run out of standard treatment options. The goal is t…

This study tests a new type of radiation therapy for women with endometrial cancer who need radiation after surgery. The treatment uses MRI scans to guide the radiation beam more precisely, which may reduce side effects like stomach or bladder problems. About 61 participants will…

This pilot study tests whether giving insulin through a nasal spray can prevent delirium (sudden confusion) in patients aged 65 and older after complex heart surgery. About 30 participants will receive either the insulin spray or a placebo to see if the approach is practical, saf…

This early-stage trial tests a personalized vaccine made from a person's own immune cells to prevent cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. The vaccine is designed to train the immune system to recognize and attack potential tumor cells…

This study will test whether 3D-printed or milled dental splints are more comfortable and fit better in 24 healthy adults. Participants will try both types and report how they feel. The goal is to help dentists choose the best method for making splints that patients can wear easi…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue in adults with inactive inflammatory bowel disease (IBD). Sixty participants will take either modafinil or a placebo for 8 weeks, and researchers will measure changes in fatigue, quali…

This study tests whether adding hydroxychloroquine to standard doxycycline treatment can reduce long-term physical complaints in adults with Lyme disease. Fifty participants will take either hydroxychloroquine or a placebo twice daily for 28 days and be followed for one year. The…

This early-phase study looks at how well an inhaled antifungal drug (liposomal amphotericin B) reaches the lungs in 18 adults with chronic pulmonary aspergillosis. Participants receive two different doses on separate days, then undergo special scans and blood tests to measure dru…

This study will check how much weight people lose after six months on tirzepatide combined with lifestyle coaching in real-world Dutch clinics. Researchers will look at medical records of 1700 adults with obesity (BMI 30+ or 27+ with related health issues) who haven't had prior o…

This study will follow 700 men with high-risk or metastatic prostate cancer to collect detailed information on how they are treated in everyday medical practice and how those treatments affect their quality of life and survival. Researchers will also gather blood and tissue sampl…

This study looks at whether a hybrid care model—using tools like telemonitoring, video visits, and online prescriptions—can help keep regular care going for people with type 2 diabetes and heart failure during health emergencies. About 180 participants will be observed and interv…