Loma Linda University

This study tests whether washing the wound with a low-dose chlorhexidine solution after a C-section helps prevent infections and improves healing compared to standard saline. The trial will include 400 women at higher risk for complications, such as those with obesity or diabetes…

This study tests a precise type of radiation called proton beam therapy for people with liver tumors that have spread from other cancers and cannot be removed by surgery. The treatment delivers high-dose radiation in three sessions over two weeks. The goal is to see if it is safe…

This phase II trial is testing a combination of proton radiation and chemotherapy (carboplatin and paclitaxel) before surgery for patients with resectable esophageal or esophagogastric junction cancer. The goal is to see if this approach is safe, tolerable, and effective at impro…

This study tests whether a team-based program (called ARTAS) helps people with HIV get connected to care after leaving the hospital and reduces the chance of coming back. The team includes infectious disease doctors and social workers who provide support during the hospital stay …

This study compares two common blood pressure medications, Nifedipine and Labetalol, to see which works better and is safer for women who develop high blood pressure after giving birth. About 500 new mothers will be randomly assigned to one of the two drugs. The goal is to reduce…

This study is testing whether washing the wound and belly cavity with a diluted iodine solution during emergency abdominal surgery can reduce surgical site infections compared to using normal saline. About 1100 adults aged 18 to 80 having certain types of emergency surgery will t…

This study tests whether giving chemotherapy and radiation before surgery can help surgeons remove all of the pancreatic cancer. About 30 adults with resectable pancreatic cancer will receive the drugs gemcitabine and nab-paclitaxel plus targeted radiation, then surgery, then mor…

This study tests whether a low dose (81 mg) of daily aspirin works as well as a higher dose (325 mg) to prevent strokes in people who have injured blood vessels in their neck or head. About 98 adults with blunt cerebrovascular injury will be randomly assigned to one of the two do…

This study looks at whether a short-term circuit strength training program can help sedentary postmenopausal women improve muscle mass, balance, quality of life, and sleep, while also reducing inflammation. Researchers will enroll 46 women aged 50 to 75 who have not exercised reg…

This study tests a new program where community health workers provide extra support to pregnant women who smoke. The goal is to help them quit smoking during pregnancy. About 105 women in San Bernardino County will take part and receive coaching to stop tobacco use.

This study looks at whether low-load blood flow restriction training (LL-BFR) can help young rowers with mild or recurring low back pain. Researchers want to see if this gentler method is as good as heavy lifting for building strength and preventing re-injury. About 120 rowers ag…

This study tests whether a community health worker can help people newly diagnosed with pancreatic cancer feel better and manage their symptoms. The health worker meets with patients and their caregivers to address physical, emotional, and practical concerns, and helps coordinate…

This study tests a gentle, hands-on technique called Strain-Counterstrain for people with pain from the piriformis muscle. Thirty adults with a tender spot in that muscle will receive a passive leg maneuver held for 90 seconds. Researchers will measure changes in pain threshold a…

This study compares two X-ray settings during a procedure to treat overactive bladder. The goal is to see if a new setting reduces radiation exposure while still placing the device correctly. About 44 adults with overactive bladder will take part. The results could make this comm…

This study tests whether adding a quick stitching step (lateral pharyngoplasty) to standard tonsillectomy helps children recover better. About 160 kids aged 3-17 will be randomly assigned to get tonsillectomy with or without the extra stitch. Parents will track pain, eating, and …

This study tests whether a powered, computer-controlled prosthetic knee helps people with above-knee amputations walk more efficiently than their usual prosthesis. Researchers will measure oxygen use during walking on flat and sloped surfaces, along with balance confidence and ef…

This study compares two standard surgical techniques for removing a testicle due to cancer. One method cuts through a muscle layer (external oblique fascia), while the other spares it. Researchers want to see if sparing the muscle leads to less pain, less need for painkillers, an…

This study looks at whether taking a 600 mg dose of gabapentin two hours before wisdom tooth surgery can lower pain and the amount of opioid painkillers needed afterward. About 98 adults will be randomly assigned to receive either gabapentin or a placebo. Researchers will track p…

This study looks at whether taking melatonin can improve sleep and daytime functioning in teenagers who have trouble falling or staying asleep. About 80 teens aged 13-17 will take either melatonin or a placebo for two weeks to see if their sleep gets better. The goal is to unders…

This study compares two non-invasive treatments—Intraneural Facilitation Therapy and standard physical therapy—for people with type 2 diabetes who have nerve pain, numbness, or tingling. Forty participants will be randomly assigned to one of the two treatments over six weeks. The…

This study looks at whether giving moms extra education about breastfeeding before they give birth helps them breastfeed exclusively for the first 6 weeks. About 196 first-time or less-experienced mothers will take part. Researchers will compare breastfeeding rates between those …

This study tests a program that combines pediatrician counseling, community health workers, and parenting educators to help families with adverse childhood experiences (ACEs). Researchers will enroll 340 children aged 3-11 and follow them for a year to see if the program lowers s…

This study looks at how the FDA-approved drug edaravone (Radicava) affects people with different forms of ALS. Researchers will collect blood, urine, and spinal fluid samples from 160 participants to measure markers of oxidative stress. The goal is to identify which ALS patients …

This study tests whether intermittent fasting—fasting for 16 hours and eating within an 8-hour window—can help healthy adults lose body fat and feel better. Researchers will measure body fat percentage and visceral fat, and track quality of life. The study involves 70 healthy par…

This study looks at whether magnesium sulfate, a common pain medicine given during surgery, changes the results of nerve monitoring tests used to protect the brain and spine. About 50 adults having spine or brain surgery will be randomly assigned to receive either magnesium or a …

This study tracks how the gums around a dental implant change shape right after the temporary crown is taken off. Researchers will use a 3D scanner to measure the gum area over 15 minutes in 34 adults who already have a front tooth implant. The goal is to find out how much time i…

This study looks at whether adding health and resilience programming—like mindfulness, lifestyle medicine, and coping plans—into the regular coursework of occupational therapy students can improve their well-being. About 130 students will take part and fill out surveys before and…

This study looks at whether trouble processing sounds (called central auditory processing disorder, or CAPD) causes poor sleep in children and teens with autism. Researchers will compare two groups of 100 kids with autism—those with CAPD and those without—using parent surveys and…

This study looks at whether what a doctor wears affects how much patients trust them. Researchers will survey 200 adults admitted to a hospital medical-surgical unit. Patients will rate their trust based on whether the doctor wears traditional attire (street clothes and white coa…

This study explores the brain basis of social difficulties in 30 teens with autism and 30 with schizophrenia. Participants take part in a 16-week social skills program called PEERS, and undergo brain scans before and after to see how the intervention affects brain networks. A con…

This study looks at how limited ankle movement affects a single-leg squat in people with long-term knee pain (patellofemoral pain). Researchers will measure ankle flexibility and pain during daily activities. The goal is to better understand the link between ankle tightness and k…

This study compares using the median nerve versus the ulnar nerve to monitor how relaxed a patient's muscles are during surgery. Researchers will measure the muscle response to nerve stimulation in 32 adults having elective surgery. The goal is to see if the median nerve works as…