Istituti Clinici Scientifici Maugeri Spa

This study is testing whether a special education program called 'Asthma School' can help adults with asthma have fewer flare-ups, emergency room visits, and hospital stays over a year. The program teaches patients how to better manage their condition and follow their treatment p…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy before surgery can shrink advanced sinonasal tumors more effectively and with fewer side effects. About 28 adults with a rare, aggressive sinus cancer will receive the combination, then …

This study is testing a new device that uses engineered bacteria and special laser technology to find and study rare tumor cells in the blood of breast cancer patients. The goal is to improve early detection and help doctors choose the best treatment for each patient. The study w…

This study is developing an artificial intelligence (AI) system to detect damage in the small bowel caused by celiac disease and similar conditions. Researchers will train the AI using past endoscopy images and then test it in a new group of 380 adult patients. The goal is to see…

This study tests a new device that uses special lights and artificial intelligence to check for leftover cancer cells during breast cancer surgery. The goal is to help surgeons remove all the cancer in one operation, reducing the need for a second surgery. About 104 women having …

This study tests whether adding musical sounds to a person's movements during physical therapy can improve walking ability. Researchers will compare standard rehabilitation to the same therapy with musical feedback in 120 adults with Parkinson's disease, stroke, or multiple scler…

This study compares two types of exercise for people with COPD who recently left the hospital after a flare-up. One group does high-intensity strength training with heavy weights and few repetitions, while the other does traditional endurance training. The goal is to see which ap…

This study is for people with primary progressive aphasia (PPA), a condition that slowly damages speech and language skills. Researchers will create personalized speech therapy exercises for 30 participants to see if they can improve word-finding, grammar, and everyday communicat…

This study tests whether daily, personalized music listening can help reduce anxiety and depression in people who recently had a stroke. 132 participants will either receive standard care plus 4 weeks of therapeutic music sessions, or standard care alone. The goal is to see if mu…

This study looks at whether adding music to standard rehabilitation exercises helps people with COPD and chronic respiratory failure walk farther and feel less tired or short of breath. About 156 participants will be randomly assigned to exercise with or without music. The goal i…

This study tests a new, personalized brain stimulation technique (HD-tDCS) to reduce chronic pain. 144 adults with long-lasting pain will receive either real or placebo stimulation over five sessions. Researchers will measure pain relief and brain changes using scans and question…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve arm and hand recovery in people who had a stroke within the last 6 months. About 48 participants will receive either real or placebo stimulation during their regular rehab session…

This study tests whether combining special prismatic glasses with mild brain stimulation (tDCS) can help people who have trouble paying attention to one side of space after a stroke. The researchers will compare this combo to glasses plus a fake stimulation in 30 adults who had a…

This study tests whether using prismatic lenses (special glasses that shift vision) combined with brain-training computer games can improve thinking and behavior in people recovering from a traumatic brain injury. Fifty adults who had a brain injury within the last 90 days will b…

This study tests whether high-tech rehabilitation—using robots, virtual reality, and balance platforms—works better than standard therapy for people with acute neuromuscular diseases like Guillain-Barré syndrome. About 124 adults aged 18-80 will be randomly assigned to either hig…

This study looks at whether maximal strength training (lifting heavy weights very fast) can help people with COPD walk more easily and feel less out of breath. Twenty adults with stable COPD will either do this strength training or standard endurance training. Researchers will me…

This study looks at how people cope physically and emotionally after losing a lower limb, often due to diabetes. Researchers will interview and test 70 participants to understand their challenges and how well they adapt. The goal is to improve rehabilitation programs by learning …

This study follows 100 people with ALS to see how their autonomic and sensory nerves change over time. Researchers will use skin biopsies and other tests to look for signs of nerve damage. The goal is to find markers that could help predict disease progression and be used in futu…

This study looks at how people with certain eating disorders think and process information. Researchers will compare adults with ARFID, anorexia, or bulimia to healthy volunteers using questionnaires and computer tasks. The goal is to learn more about mental flexibility, body per…

This study looks at how a specific part of the brain, the ventromedial prefrontal cortex, helps us mentally travel backward to remember past events or forward to imagine future ones. Researchers will compare people with focal brain injuries to healthy individuals to see if damage…

This study looks at how multiple sclerosis (MS) affects the autonomic nervous system, which controls things like blood pressure, sweating, and body temperature. Researchers will study 60 people with two types of MS (relapsing-remitting and primary progressive) during a rehabilita…

This study looks at how changes in muscles and nerves might be early signs of brain diseases like Alzheimer's, Parkinson's, and ALS. Researchers will compare healthy older adults, those with early signs of aging problems, and people with these brain diseases. The goal is to find …

This study uses a survey to find out how aware people with existing heart disease are about their risk factors and future heart problems. Researchers will compare answers from 200 women and men to see if there are differences. The goal is to understand gaps in knowledge so doctor…

This study is observing 280 people with Parkinson's disease or multiple system atrophy to understand how pain and automatic body functions (like sweating, digestion, and heart rate) affect their daily lives. Researchers will track symptoms before and after a rehabilitation progra…

This study is developing and testing an Italian version of a questionnaire called the Waddell Disability Index, which measures how much chronic low back pain affects daily life. Researchers will enroll 115 adults who have had low back pain for at least 3 months. Participants will…

This study takes small tumor samples from 240 women with invasive breast cancer who are about to receive chemotherapy before surgery. Researchers will grow these samples into mini-tumors (organoids) in the lab to study each cancer's unique features. The goal is to see if these or…

This study uses brain scans (fMRI and EEG) to understand how healthy people process social information like empathy and reading others' thoughts. Researchers will look at brain activity in 200 healthy adults to see which areas are involved and how this changes with age. The goal …

This study tests the drug pembrolizumab in people with high-risk thyroid cancer before they have surgery. The goal is to see how the drug affects immune cells in the tumor and blood. About 25 adults will take part. This is a phase 2 trial, so it is still early, but it may help do…

This study looks at why people with obstructive sleep apnea often struggle to stick with CPAP therapy, the standard treatment. Researchers will test 64 adults to see if their decision-making style—specifically how much effort they're willing to put in for a reward—predicts poor C…

This study is testing a new, highly sensitive blood test to detect tiny particles called extracellular vesicles released by breast cancer cells. Researchers will compare levels of these particles in 105 women with early or metastatic breast cancer and healthy volunteers. The goal…

This study tracks 30 adults with hereditary angioedema (HAE) using daily smartphone surveys for 8 weeks. The goal is to capture the real-time emotional, social, and physical burden of the disease, which may be missed by standard questionnaires. Participants answer questions about…

This study uses brain scans (fMRI) to understand how healthy people make decisions and how aging changes this process. Researchers will recruit 150 healthy adults to complete thinking tests and brain imaging. The goal is to create a baseline for future studies on decision-making …

This study looks at how unconscious factors, like how information is presented, affect decision-making in healthy people. Researchers will test 200 volunteers to see if these factors change with age. The goal is to create a baseline to better understand decision-making problems i…

This study explores whether combining biological tests, psychological assessments, and social factors can lead to earlier and more accurate diagnosis of Alzheimer's disease. Researchers will follow 80 people with cognitive decline and their caregivers, using memory tests, blood m…

This study looks at whether giving extra oxygen during a 6-minute walk test helps people with chronic lung disease walk farther and feel better. About 114 adults with conditions like COPD or lung scarring will do two walking tests—one with their usual oxygen and one with extra ox…