Fred Hutchinson Cancer Center

This study looked at whether giving a JAK inhibitor drug before a donor stem cell transplant helps people with myelofibrosis, a serious bone marrow disorder. The goal was to reduce symptoms like an enlarged spleen and improve survival after transplant. 61 patients took part in th…

This study tested different drug combinations to prevent graft-versus-host disease (GVHD) in 174 people with blood cancers receiving stem cells from an unrelated donor. GVHD is a serious side effect where donor cells attack the patient's body. The goal was to find which drug regi…

This study tested whether a home-based physical activity program, delivered by mail and phone without in-person visits, could help older women reduce their risk of heart attacks, strokes, broken bones, and falls. About 50,000 women already in the Women's Health Initiative took pa…

This study tested a digital chatbot called QuitBot to see if it could help people stop smoking. Over 1,600 adult smokers who wanted to quit were randomly assigned to use QuitBot or another program. The main goal was to see how many people had not smoked for at least 30 days after…

This study looked at whether a diet and physical activity program could help prevent or reduce the metabolic side effects (like weight gain, insulin resistance, and unhealthy cholesterol levels) caused by hormone therapy in men with prostate cancer. Twenty men who were receiving …

This study tested a new combination of drugs (treosulfan, fludarabine, and rabbit antithymocyte globulin) given before a bone marrow transplant to 40 patients with bone marrow failure diseases. The goal was to see if this approach could lower the risk of serious complications lik…

This study tested a method to prevent graft-versus-host disease (GVHD) in 84 leukemia patients receiving donor stem cell transplants. By removing a specific type of immune cell (naive T cells) from the donor graft, researchers aimed to lower GVHD risk while preserving infection-f…

This study tested whether giving two drugs—ixazomib and lenalidomide—in an alternating schedule after a stem cell transplant could safely delay the return of multiple myeloma. Thirty patients who had already received a transplant took part. The main goal was to check for side eff…

This study tested different ways to provide HIV prevention medication (PrEP) through local pharmacies in Kenya. Over 5,800 people participated across 60 pharmacies. The goal was to see if offering PrEP directly at pharmacies, instead of referring people to clinics, helps more peo…

This study tested a new way to help young women in Kenya start PrEP, a daily pill that prevents HIV. Young women already taking PrEP were trained to refer their friends and give them HIV self-test kits. The goal was to see if this peer-led approach could increase PrEP use among t…

This study tested a smartphone app designed to help young cancer survivors (ages 15-29) manage anxiety. The app uses simple games to retrain the brain to focus on positive things instead of threats. Researchers wanted to see if the app was easy to use and if people liked it. 70 s…

This study looked at whether following a healthy diet, based on the Alternative Healthy Eating Index, could help reduce pain and improve quality of life in women with endometriosis. 109 women with confirmed endometriosis and significant pain took part. Researchers measured pain l…

This study tested whether anakinra, a drug used for rheumatoid arthritis, could prevent two serious side effects of CAR-T therapy: cytokine release syndrome (CRS) and nerve damage. 27 adults with B-cell lymphoma received anakinra alongside their CAR-T treatment. The goal was to s…

This pilot study looked at whether providing plant-based, whole-food meals to multiple myeloma patients during stem cell transplant is practical and well-tolerated. The goal was to see if this diet could help maintain healthy gut bacteria, which is often damaged during treatment.…

This study tested a website designed to help people with advanced cancer plan for end-of-life care, including medical wishes, legal documents, and financial tasks. About 100 patients took part to see if the tool reduced distress and improved planning. The goal was to learn whethe…

This study looked at whether cancer survivors in rural areas can benefit from creating their own survivorship care plans and receiving education over the phone. 261 survivors of breast, colorectal, lung, prostate cancer, or lymphoma took part. The goal was to see if this approach…

This study tested a program called PLAN that helps Latino cancer patients understand and talk about the medical care they would want if they couldn't speak for themselves. 27 patients with advanced cancer took part. The goal was to see if the program was helpful and improved thei…

This study gave a rabies vaccine to people who had CAR-T therapy for B-cell cancer and to healthy volunteers. The goal was to see how well the immune system works after CAR-T treatment. Researchers measured antibody levels to understand vaccine response, which can help doctors pr…

This study tested a program to help adolescent and young adult cancer survivors (ages 15-39) get better access to healthcare resources and learn self-management skills. 549 survivors of cancers like leukemia, lymphoma, melanoma, and breast cancer took part. The goal was to see if…

This study tested a program called GUIDE, where a trained navigator helps cancer patients overcome social and financial barriers to join clinical trials. 100 adults with cancer who were eligible for a trial and had at least one social need (like trouble with food, housing, or tra…

This study followed 267 adults who had a stem cell transplant to learn more about chronic graft-versus-host disease (GVHD), a common complication. Researchers collected blood, saliva, and tissue samples over time to see if certain proteins or cells could predict who would develop…

This study tested a simple checklist tool to help people with sarcoma think about and plan for their future mobility needs, like getting around the house or dressing. Researchers worked with 27 patients who had either limb-saving surgery or amputation, or had advanced sarcoma. Th…

This study tested a new method to evaluate tuberculosis (TB) drugs and vaccines in 20 healthy adults. Researchers used a harmless version of the TB bacteria (BCG) to see how the body fights it and how treatments work. The goal was to create a faster, safer way to test new TB trea…