Arthritis drug may tame CAR-T's dangerous side effects
NCT ID NCT04359784
First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 24 times
Summary
This study tested whether anakinra, a drug used for rheumatoid arthritis, could prevent two serious side effects of CAR-T cell therapy: cytokine release syndrome (CRS) and nerve damage. 27 adults with B-cell lymphoma received anakinra alongside their CAR-T treatment. The goal was to see if anakinra could reduce the occurrence of these side effects without affecting the cancer-fighting power of the CAR-T cells.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Fred Hutch/University of Washington Cancer Consortium
Seattle, Washington, 98109, United States
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