Fred Hutchinson Cancer Center

This early-phase study tests a personalized vaccine made from each patient's unique tumor markers (neo-antigens) to help their immune system fight cancer. It includes up to 25 adults with advanced melanoma, breast cancer, or non-small cell lung cancer that has not responded to st…

This study tests a radioactive antibody (211At-BC8-B10) that seeks out and attacks cancer cells, followed by a donor stem cell transplant for people with high-risk leukemia or myelodysplastic syndrome (MDS) that has returned or not responded to treatment. The goal is to find the …

This study tests a new treatment approach for adults aged 60 and older with newly diagnosed, high-risk acute myeloid leukemia (AML) or similar blood cancers. The plan combines strong chemotherapy (FLAG-Ida) with a donor stem cell transplant given just days later, aiming to shorte…

This study tests if the antiviral drug remdesivir can safely treat RSV (a common respiratory virus) in 60 adults whose immune systems are weakened by certain cancer or autoimmune treatments. Participants have a confirmed RSV infection in the upper airways. The main goal is to see…

This study tests a special cord blood transplant for people with high-risk blood cancers like leukemia and lymphoma. Participants get chemotherapy and radiation before the transplant to kill cancer cells and prepare the body. After the transplant, drugs are given to prevent the n…

This study tests whether a faster, hospital-based dose increase of the drug sonrotoclax, given with other targeted therapies, is safe and tolerable for people with chronic lymphocytic leukemia, small lymphocytic lymphoma, or mantle cell lymphoma. The trial enrolls 30 adults whose…

This early-stage trial tests a new treatment for children and adults (ages 0-80) whose leukemia has come back or not responded after a donor stem cell transplant. The treatment involves taking donor immune cells, adding a special receptor so they can recognize and attack leukemia…

This early-stage study tests whether giving patients a fecal transplant (donated stool) along with extra dietary fiber can help treat gut graft-versus-host disease, a serious complication after a bone marrow transplant. About 72 adults who had a stem cell transplant in the past y…

This study tests whether adding an experimental drug called ST-067 to standard CAR T-cell therapy can improve outcomes for people with large B-cell lymphoma that has returned or not responded to prior treatments. About 33 adults will receive the combination therapy to see if it i…

This study looks at whether high-intensity exercise and a high-fiber diet are practical and helpful for people with advanced melanoma who are receiving immunotherapy. About 40 adults will be assigned to exercise, diet changes, both, or standard care. The goal is to see if these l…

This study tests a radioactive antibody (211^At-BC8-B10) given before a donor stem cell transplant for people with high-risk acute leukemias or myelodysplastic syndrome. The antibody targets cancer cells and delivers radiation to help kill them while sparing healthy cells. The go…

This study is for children and young adults with blood cancers who are getting a donor stem cell transplant. The goal is to see if removing a specific type of immune cell (naive T cells) from the donated cells can prevent chronic graft-versus-host disease, a serious condition whe…

This study tests a drug called axatilimab for people whose skin becomes thick and hard (sclerotic) after a donor stem cell transplant, a condition called chronic graft-versus-host disease. The drug aims to block immune signals that cause inflammation and scarring. About 50 adults…

This study tests a stem cell transplant from half-matched (haploidentical) donors for people with various blood cancers. Before the transplant, patients receive chemotherapy and low-dose radiation to prepare their body. The goal is to replace diseased bone marrow with healthy don…

This study tests whether adding the drug ruxolitinib before, during, and after a donor stem cell transplant can help prevent graft-versus-host disease (GVHD) in older adults with myelofibrosis or related blood cancers. About 50 participants will receive ruxolitinib plus standard …

This study compares a new smartphone app (IndigeQuit) to an existing app (NCI QuitGuide) to help American Indian and Alaska Native adults quit smoking. About 776 participants who smoke daily and want to quit within 30 days will use one of the apps. The goal is to see if IndigeQui…

This study is for people under 50 with non-cancerous blood or immune system diseases that can be treated with a donor stem cell transplant. Doctors want to see if a milder combination of chemotherapy drugs (treosulfan, fludarabine, and thiotepa) can safely prepare the body for ne…

This study is for people with a bone marrow cancer called myelofibrosis. It tests whether giving a JAK inhibitor drug before, during, and after a stem cell transplant from a half-matched donor can lower the risk of a serious side effect called graft-versus-host disease. About 20 …

This early-phase trial tests a drug called DR-18 in 20 adults whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) has returned or persists after a stem cell transplant. DR-18 is designed to boost the body's immune system to fight the cancer. The main goals are to…

This study tests a new combination of two drugs (pralatrexate and bendamustine) plus low-dose total-body radiation given before a donor stem cell transplant for people with T-cell lymphoma that has come back or not responded to treatment. The goal is to see if this approach is sa…

This study tests whether the drug belumosudil can prevent chronic graft-versus-host disease (cGVHD) from getting worse after a stem cell transplant. cGVHD is a common complication where the donor's immune cells attack the patient's body. The trial will compare belumosudil to a pl…

This study tests two remote weight loss programs designed for Latina breast cancer survivors who have finished initial cancer treatment. The goal is to help participants lose weight and improve their long-term health. Researchers will enroll 640 women to see which approach works …

This study tests a new approach for adults with aggressive blood cancers (like AML) that are likely to return after standard treatment. Participants receive a combination of chemotherapy drugs (decitabine plus FLAG-Ida) and low-dose radiation, followed immediately by a stem cell …

This study tests whether adding vorinostat (a drug that may make cancer cells more sensitive) to a standard radioactive therapy (177Lu-PSMA-617) can help men whose advanced prostate cancer has low levels of a specific marker (PSMA). About 15 men with castration-resistant prostate…

This study tests whether reducing the dose of the drug linvoseltamab, based on how well a patient responds early on, is safe and effective for people with multiple myeloma that has returned or stopped responding to other treatments. The goal is to keep the cancer under control wh…

This study tests whether giving immunoglobulin (antibodies from donors) can prevent serious infections in people who have received CAR-T cell therapy for blood cancers. CAR-T therapy often lowers the body's own antibodies, raising infection risk. The trial will compare immunoglob…

This study tests two different methods to lower the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body, after a stem cell transplant. About 120 adults with acute leukemia or myelodysplastic syndrome (MDS) in remission will…

This study tests a combination of two drugs, acalabrutinib and venetoclax, in people whose chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) has returned or stopped responding to treatment. The goal is to see if the combo can kill more cancer cells and achiev…

This study is for adults with certain blood cancers (like acute myeloid leukemia) that have come back or not responded to treatment. It tests a powerful chemotherapy followed by a stem cell transplant from a donor. The goal is to find the best dose of total body irradiation to ki…

This early-stage trial tests a new treatment called FOLR1 CAR T for children aged 6 or younger with a type of leukemia (AML) that has returned or not responded to standard therapy. The treatment involves taking a child's own immune cells, modifying them in a lab to recognize and …

This early-phase trial tests a personalized treatment for people with metastatic solid tumors that have a specific genetic change called KRAS G12V. The patient's own immune cells (T cells) are collected, genetically modified to recognize and attack cancer cells carrying the KRAS …

This study tests a new treatment for men with advanced prostate cancer that has spread and no longer responds to standard hormone therapy. The treatment uses the patient's own immune cells, modified in a lab to better recognize and attack prostate cancer cells, combined with a ho…

This early-stage trial tests a new treatment for advanced osteosarcoma that has come back or spread. The treatment uses a patient's own immune cells, modified in a lab to recognize and attack cancer cells that have a specific marker called FOLR1. Up to 30 people aged 1 to 75 will…

This study tests a new approach to prepare adults with non-cancer diseases for a stem cell transplant. A special antibody carrying a radioactive particle targets and destroys harmful bone marrow cells, while low-dose total body radiation is also given. The goal is to prevent the …

This study tests whether the antibiotic rifaximin can reduce abnormal proteins in people with a precancerous blood condition called IgA MGUS. About 50 adults will either receive the drug or no treatment. The goal is to see if rifaximin can lower the risk of progression to multipl…

This study tests whether adding a targeted drug (nemtabrutinib) to a special immune cell therapy (CAR T-cells) can help people with chronic lymphocytic leukemia or small lymphocytic lymphoma that has returned or stopped responding to treatment. About 20 adults will receive the co…

This study tests whether a dental cleaning shortly after a stem cell transplant can prevent chronic graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. Researchers will enroll 45 adults receiving a stem cell transplant for blood c…

This study compares two versions of a mobile app called LiFT (Living Free from Tobacco) to help young adults ages 18-30 quit nicotine and tobacco products. About 140 participants will use one of the two app versions and report their satisfaction and how helpful the program was. T…

This study tests whether limiting eating to an 8-hour window each day (time-restricted eating) can improve how well cancer treatments work and reduce side effects. It enrolls 100 Alaska Native or American Indian adults with rectal or breast cancer who are about to start treatment…

This study tests a smartphone app called ACT on Vaping to help young adults (ages 18-30) quit using e-cigarettes. The app uses behavioral therapy to help users recognize triggers and build skills to stop vaping. About 1,178 participants will use the app or a control, and research…

This study tests whether a specific type of exercise—aerobic interval training—can boost the immune system and improve how well immunotherapy works in people with non-small cell lung cancer. About 100 participants who are already on immunotherapy will either exercise or not, and …

This study tests whether a telephone coaching program called Talking About Cancer (TAC) helps people with advanced cancer and their support person engage in advance care planning, such as having end-of-life conversations and completing advance directives. About 80 patients and th…

This study looks at how to help people in Zimbabwe who have both cancer and HIV stay engaged in their HIV care while they are being treated for cancer. Researchers will first observe 150 patients to understand the barriers they face, then develop and test strategies to make it ea…

This study looks at whether moderate-to-vigorous exercise can change the gut bacteria of people who have had stage II or III colorectal cancer. Researchers want to see if these changes might help improve cancer outcomes. The study involves 30 survivors and focuses on whether the …

This study aims to create simple screening tools to identify financial hardship in people with Alzheimer's and their caregivers. Researchers will interview patients and caregivers, then survey large groups to develop and test the measures. The goal is to help healthcare providers…

This study looks at whether patient navigation services, an interactive website, or both can help people who had stage I-III colorectal cancer get the recommended follow-up tests after surgery. About 75 survivors will be assigned to one of three groups to see which approach works…

This study looks at whether adults with acute myeloid leukemia (AML) who are not healthy enough for strong chemotherapy are willing to let a computer randomly assign them to either lower- or higher-intensity treatment. The goal is to see if this approach is acceptable to patients…

This study looks at whether adding fiber to the diet is possible for patients receiving donor stem cell transplants for blood cancers. The goal is to see if fiber can support nutrition, gut health, and recovery. About 40 adults will take part to test how well they can tolerate an…

This study tests a cooking and nutrition program for adults in southern New Mexico, where cancer and obesity rates are high. The goal is to see if teaching healthier cooking techniques can improve diet quality and knowledge about cancer prevention. Researchers will enroll 80 peop…

This study enrolls 300 adults with chronic graft-versus-host disease (cGVHD) who are starting a new therapy. Researchers collect blood samples and clinical data before and after treatment to look for changes that might predict how well a person will respond. The goal is to better…

This study is testing a mobile app called PACT that helps people with advanced cancer talk about and plan the care they would want if they couldn't speak for themselves. About 400 patients and their support persons will use the app and report how easy it is to use and whether it …

This study watches 250 people who had a donor stem cell transplant to see if respiratory viruses lead to a lung condition called bronchiolitis obliterans syndrome (BOS). Participants use a simple home device to check their lung function regularly. The goal is to catch lung proble…

This study looks at whether a patient navigator or a website called PACT can help people who had a stem cell transplant for blood cancer plan their future medical care. About 40 adults who are 1 to 5 years post-transplant will be enrolled. The goal is to see if these tools help p…

This study tests a workshop called HOPE-C, designed to reduce burnout among doctors, nurses, and social workers who care for ovarian cancer patients. The workshop helps clinicians share their challenging stories and build peer support. Researchers will enroll 25 participants to s…