Fred Hutchinson Cancer Center

This study looks at children and teens with HIV to find the best number of HPV vaccine doses. Researchers are comparing one, two, or three doses to see if fewer shots can still provide strong protection against HPV. The goal is to simplify vaccination and improve health outcomes …

This study tests two different phone-based counseling programs to help overweight or obese people with obesity-related cancer lose weight. Participants will receive coaching on diet, exercise, and behavior change over the phone. The goal is to see which approach leads to more wei…

This study looks at whether offering extra support—like a patient navigator, an educational video, and free rides home after the procedure—can help more people complete a follow-up colonoscopy after an abnormal stool-based cancer screening test. About 682 adults aged 45 to 75 who…

This study compares two different chemotherapy combinations (treosulfan-based vs clofarabine-based) given before a donor stem cell transplant for people with myelodysplastic syndromes or acute myeloid leukemia. The goal is to see which regimen helps patients live longer without t…

This study tests whether giving full-strength chemotherapy (either CPX-351 or a combination called CLAG-M) can help medically less-fit adults with acute myeloid leukemia live longer and achieve remission. About 60 participants will receive one of the two treatments. The goal is t…

This early-stage trial tests a new targeted drug called pivekimab sunirine (PVEK) combined with standard chemotherapy for adults with aggressive acute myeloid leukemia (AML) and related blood cancers. PVEK works like a smart bomb, attaching to cancer cells and delivering chemo di…

This study tests whether adding ruxolitinib to standard medications can prevent graft-versus-host disease (GVHD) in adults over 40 receiving a stem cell transplant for aplastic anemia, a condition where the bone marrow fails to produce enough blood cells. GVHD occurs when donor i…

This study tests whether giving the drug ruxolitinib before, during, and after a donor stem cell transplant can prevent a serious side effect called graft-versus-host disease (GVHD) in people with myelofibrosis, a type of bone marrow cancer. About 53 adults with intermediate- or …

This early-phase trial studies whether adding an experimental drug called NKTR-255 to standard CAR-T cell therapy can safely improve outcomes for adults with large B-cell lymphoma that has returned or not responded to treatment. The drug is designed to boost the immune system's c…

This study tests whether a smartphone app called Quit2Heal can help cancer patients stop smoking better than another app, QuitGuide. About 427 adults with cancer who smoke will use one of the two apps to get tools and tips for quitting. The main goal is to see how many people can…

This study tests a treatment where a patient's own immune cells are modified in a lab to recognize and attack a protein called CD20 on lymphoma cells. It is for people with B-cell non-Hodgkin lymphoma that has come back or not responded to prior therapy. The goal is to find the s…

This study tests whether the drug ustekinumab can prevent acute graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers. GVHD occurs when donor cells attack the patient's body. The trial involves 116 adults aged 18-70 and compares ustekinumab …

This study tests a drug called acalabrutinib in 51 adults with moderate to severe chronic graft-versus-host disease (GVHD), a complication after a stem cell transplant. The goal is to see if the drug can control the disease when steroids have stopped working. Participants take th…

This study tests a strong chemotherapy combination followed by a stem cell transplant in 53 people with autoimmune neurologic diseases (like multiple sclerosis or stiff person syndrome) that did not improve with standard treatments. The goal is to weaken the overactive immune sys…

This study tests different screening methods to find early signs of cervical cancer in 619 women living with HIV in the Dominican Republic. The goal is to see which approach—like checking for HPV—works best to catch precancerous changes early. Results could lead to better screeni…

This study tests whether giving patients a transplant of healthy gut bacteria (from donated stool) can prevent severe graft-versus-host disease (GVHD) after a stem cell transplant. GVHD is a serious complication where donor immune cells attack the patient's body. The trial involv…

This study tests a program designed to help men who have sex with men in Lima, Peru get tested for HIV and connect to treatment or prevention services. The program offers HIV testing at social venues and provides a text-messaging app with health information and support from a hea…

This study tests a program called HOPE (Helping Ovarian Cancer Patients Cope with Their Disease) to see if it can reduce feelings of hopelessness and helplessness in patients whose ovarian cancer has returned. About 60 adults with recurrent ovarian cancer will either take part in…

This study tests a remote program that combines mindfulness with nutrition and cooking lessons to help breast cancer survivors eat better. About 49 people who had stage I-III breast cancer in the past 5 years will take part. The program is delivered online through the Cook for Yo…

This study aimed to test a smartphone app designed to help LGBTQ+ young adults (ages 18-30) in New Mexico quit smoking. The app included culturally tailored content and an avatar guide. However, the study was withdrawn before any participants were enrolled, so no results are avai…

This study looks at inherited gene changes (like BRCA1 and BRCA2) in men with prostate cancer. Researchers will collect saliva samples and health information from 1,360 men in Washington state. The goal is to learn how often these gene changes occur and how they might guide bette…

This study involves 383 people with chronic Graft-versus-Host Disease (GVHD), a complication after stem cell transplants. Researchers are creating and testing new ways to measure if treatments are working, like the Chronic GVHD-Activity Index. The goal is to better predict which …

This study looks at whether new guidelines from the National Institutes of Health can help doctors better diagnose and track chronic graft-versus-host disease (GVHD), a common complication after stem cell transplants. Researchers are following 601 patients over several years, col…

This study looks at whether adding care coordination services—like tracking results, sending reminders to patients, and helping doctors follow up—can improve how often people get the right follow-up after lung cancer screening. It involves about 6,700 participants aged 50-80 who …

This study tests whether personalized coaching and mobile apps can help cancer survivors become more physically active and improve their diet. About 374 adult survivors of childhood or young adult cancers will participate. The goal is to see if these programs lead to lasting heal…