Duke University

This study is for people with HPV-related oropharynx (throat) cancer. It uses a PET/CT scan taken during radiation treatment to see if the cancer is responding well. If it is, doctors will lower the radiation dose for the rest of treatment. The goal is to reduce side effects whil…

This early-stage trial tests whether adding abatacept to standard anti-rejection drugs can safely prevent graft-versus-host disease (GVHD) in 10 adults with blood cancers receiving a special type of stem cell transplant (omidubicel). Participants will receive the drug combination…

This phase 2 trial tests whether adding two immunotherapy drugs (nivolumab and relatlimab) to standard treatment can help people with newly diagnosed glioblastoma, an aggressive brain cancer. About 92 adults will receive the drugs before and after surgery to see if it is safe and…

This study is testing a new way to detect cervical cancer using light instead of traditional tissue samples. Researchers will shine light on the cervix to find unique patterns that signal early cancer or pre-cancer. The goal is to make diagnosis faster, less painful, and more acc…

This study looks at whether DNA markers in urine can help diagnose and monitor upper tract urothelial cancer (UTUC). Researchers will collect urine samples from 50 patients before surgery and during follow-up visits. The goal is to see if these markers can detect cancer earlier a…

This study aims to see if new tests can quickly spot a gene mutation that makes gonorrhea resistant to the antibiotic ciprofloxacin. About 3,300 people with gonorrhea will provide samples (urine, vaginal, or throat swabs) already collected for routine care. The goal is to help do…

This study tests whether inclisiran, a twice-yearly injection already approved to lower bad cholesterol, can prevent major heart and limb events in 6,000 adults who recently had artery-opening procedures. Participants receive either inclisiran or a placebo, and researchers track …

This study tests a new online program called UPDOs Protective Styles to help Black women in the southeastern US learn about and start using PrEP, a daily pill that prevents HIV. About 1,000 women from 32 beauty salons will either use the program (videos, blogs, and telehealth) or…

This study tests a mobile app called ICUconnect that helps older ICU patients and their families report their palliative care needs directly to doctors. The goal is to improve care and reduce emotional distress. About 350 patient-family pairs from four hospitals will use the app …

This study tests whether training caregivers of young autistic children (18–72 months) in South Africa can improve the child's communication and daily living skills. Non-specialist coaches teach caregivers strategies they can use during everyday activities. The goal is to support…

This study tests a short, phone-based pain coping skills training for women aged 55 and older with breast cancer who have ongoing pain. The program includes one main session and five short follow-up calls. Researchers will measure pain, quality of life, and confidence in managing…

This study is creating and testing a nurse-led program to help women who go through early menopause after cancer treatment. The program offers personalized education, decision support, and skills to manage symptoms. Researchers want to see if the program is easy to use and if it …

This study looks at whether yoga can improve overactive bladder symptoms in children aged 8 to 18. Participants attend a weekly yoga session for 6 weeks. Researchers will track symptom changes using questionnaires and urine tests. The goal is to find a gentle, non-drug option for…

This study compares a single dose of methadone (a long-acting opioid) to standard short-acting opioids for pain control after tonsillectomy in children aged 3 to 17. The main goal is to see if fewer children need extra pain medicine in the recovery room. The study involves 440 pa…

This study tests if a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help people with type 1 diabetes who also have an eating disorder. About 235 people aged 16–50 will be assigned to ACT, supportive diabetes counseling, or a waitlist. Researchers will ch…

This study tests whether injecting numbing medicine near the femoral artery can reverse high blood pressure caused by a tourniquet during ankle surgery. About 40 adults having total ankle replacement will be randomly assigned to receive the injection or a placebo. The goal is to …

This study tests a gentle ultrasound technique called LIFUS to see if it can improve arm weakness in people who had a stroke. Researchers will try different power levels and timing to find the best settings. 24 adults with arm weakness from a first stroke will participate. The go…

This study tests whether a non-invasive brain stimulation technique called TMS can improve working memory in healthy older adults and those with mild cognitive impairment (MCI). Researchers will use brain scans to personalize the stimulation for each participant. The goal is to u…

This study looks at how long-term opioid therapy changes brain and spinal cord activity in women with chronic pain. Researchers will compare brain scans of women with chronic pain, those with opioid use, and healthy women. The goal is to find new ways to treat chronic pain withou…

This study looks at how quitting smoking temporarily increases pain, especially in people with chronic pain. Researchers will use brain scans to see how withdrawal changes pain processing and whether this makes it harder to stop smoking. About 132 smokers, some with chronic back …

This study enrolls 100 emergency medicine physicians to test whether a simulation-based ultrasound workshop improves their diagnostic skills. Participants take a knowledge test before and after the workshop, and their hands-on skills are assessed with an objective exam. The goal …

This study looks at whether switching to very low nicotine cigarettes affects cravings, withdrawal, and pain in daily smokers who have chronic pain and are on buprenorphine treatment for opioid use disorder. About 60 adults will be assigned to either low-nicotine or regular-nicot…

This study is for women with breast cancer who are receiving a treatment that greatly lowers estrogen levels. Researchers want to see if this treatment changes how the heart works. They will use heart scans to measure blood flow in 90 women over two years. The goal is to learn mo…

This study is for people with prostate cancer who are already in the SYNERGY-201 trial, which tests a drug combination (SX-682 and enzalutamide). The goal is to see if a biomarker called CXCR2 can predict who will benefit from that treatment. Researchers will collect blood and tu…

This study looks at what factors—like genetics, immune system, and medical history—affect survival and quality of life in adults with glioblastoma, a severe brain cancer. About 200 participants will fill out online surveys and may provide a blood sample at home. The goal is to le…

This study aims to better understand sleep and internal body clocks in 250 children aged 6-9 with ADHD. Researchers will use home sensors, parent surveys, and a lab test to measure melatonin, a key sleep hormone. The goal is to see how sleep relates to children's mental health an…

This study looks at why people with rheumatoid arthritis often have trouble controlling high blood pressure, which raises their risk of heart disease. Researchers will work with 25 adults to test a program that helps them monitor their blood pressure and share results with their …

This study follows up to 200 children and adults with hypophosphatasia, a rare genetic disorder that weakens bones and teeth. Researchers will collect medical history, treatment details, and quality-of-life information to better understand how the disease progresses and affects d…

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation training can help people with mood, anxiety, or impulse disorders better control their emotions. 240 adults aged 18-55 with high emotional distress will be randomly assigned to …

This study aims to create a smart computer program that helps doctors better understand the sounds from a handheld device used to check blood flow in arteries. Many doctors lack formal training in using this device, which can lead to missed or wrong diagnoses. The study will coll…

This study uses a comfortable headband to monitor sleep and brain activity in people with epilepsy who still have seizures despite medication. The goal is to understand how poor sleep increases seizure risk, so doctors can offer more personalized treatments. 35 adults with at lea…

This study aims to create a nationwide registry of 400 people who have experienced drug-induced liver injury (DILI). Researchers will collect medical information and biological samples like blood and DNA to build a resource for future studies. The goal is to better understand why…

This study explores whether drones can deliver automated external defibrillators (AEDs) to rural cardiac arrest scenes faster than traditional emergency responders. About 128 adults experiencing sudden cardiac arrest will be included. The goal is to see if drone delivery is quick…

This study tests a program called CO-LEAD that helps doctors and lupus patients communicate better about medications. Doctors learn special communication skills, and patients use a tool to share their medication challenges. The goal is to see if this leads to more open discussion…