Duke University

This study tests a structured nutrition plan for 300 ICU patients who had abdominal surgery and cannot eat normally. The plan uses tube feeding, supplements, and a device to measure calorie needs. Researchers will track infections, hospital stay length, and muscle changes to see …

This study is for people with stage 1B to 3A non-small cell lung cancer who will have surgery. Participants receive chemotherapy and an immunotherapy drug (cemiplimab) with or without a cholesterol-lowering drug (alirocumab) before surgery. The goal is to see if adding alirocumab…

This study tests whether combining text message support for pregnant women who smoke with special training for their OB doctors can help them quit. About 840 women from Duke and Pitt will take part. All receive smoking cessation texts; some doctors get extra counseling training. …

This study looks at whether giving a lower dose of radiation (20 Gy instead of 30 Gy) to a smaller area can still keep lymphoma from coming back in patients who had a clear PET scan after chemotherapy. About 241 adults with diffuse large B-cell lymphoma are taking part. The goal …

This study tests whether a rapid form of brain stimulation (accelerated TMS) can improve hand function in people with focal hand dystonia, a condition that causes muscle cramps during tasks like writing. Twenty-one adults will receive four TMS sessions in one day and be monitored…

This study tests whether a special ketone drink can help people with heart failure feel less tired and short of breath during exercise. Researchers will measure exercise capacity and heart function in 25 adults with reduced ejection fraction. The drink is considered safe by the F…

This study tests whether advanced brain imaging can help doctors fine-tune deep brain stimulation (DBS) for Parkinson's disease. Twenty adults who already have DBS implants will have their stimulation settings adjusted based on detailed brain maps. The goal is to better control t…

This study explores whether playing virtual reality games can help patients in the intensive care unit move their arms and hands more, and improve their mood. About 30 adults who have been in the ICU for at least 3 days will try a VR game once a day or more. Researchers will meas…

This study looks at how different patterns of deep brain stimulation (DBS) affect movement symptoms and brain activity in people with Parkinson's disease, essential tremor, multiple sclerosis, or dystonia. Researchers will test non-regular stimulation patterns to find ways to mak…

This study aimed to check how consistent MRI scans are in people with a slow-growing brain tumor (IDH1-mutant low-grade glioma) who were taking the drug ivosidenib. The goal was to improve how doctors measure tumor changes over time. However, the study was withdrawn before enroll…

This study looks at whether using lower doses of radiation for a type of eye cancer called ocular melanoma can still keep the cancer from coming back, while causing fewer side effects. Researchers are tracking 42 adults with small or medium eye tumors who received radiation thera…

This study looks at whether adding geriatric care to regular dialysis treatment helps older patients manage common problems like depression, memory trouble, falls, and medication issues. About 120 dialysis patients aged 55 and older will take part. The goal is to see if this appr…

This study is creating a large community registry and biorepository with 50,000 volunteers from Cabarrus County and Kannapolis, NC. Participants provide health information and samples to help researchers better understand chronic diseases and improve future medicine. No direct tr…

This study tests a program called HOP-STEP that helps doctors talk to women with lupus about pregnancy planning and birth control. The goal is to improve how doctors document contraception use and pregnancy intentions, especially in clinics serving high-minority and low-income co…

This study aimed to see if time-restricted eating (eating only during a 10-hour window each day) could improve how well immunotherapy works in people with advanced head/neck or kidney cancer. Researchers planned to track changes in gut bacteria and immune cells. The study was wit…

This study at Duke University is testing whether a special type of MRI (using xenon gas) can detect changes in lung scarring in people with progressive pulmonary fibrosis. About 60 adults will have MRI scans before starting anti-fibrotic medication and again at 3, 6, and 12 month…

This study planned to create a robot that helps doctors take detailed 3D pictures of the back of the eye, especially hard-to-see areas. It was designed for healthy adults over 18. However, the study was withdrawn before any participants were enrolled, so no results are available.

This study is testing a new program called mSTARS for people who are leaving the hospital after a suicide crisis and also drink heavily. The program combines in-hospital therapy with a smartphone app to help manage emotions and reduce risk. Ten participants will try it and give f…