Duke University

This study tests whether a vaginal probiotic can help prevent recurrent urinary tract infections (UTIs) in women. Researchers will give participants a commercially available Lactobacillus probiotic for 3 months and track how well it colonizes the vagina and urinary tract. The goa…

This study tests a program called CROSSROADS for adults who recently survived an opioid or stimulant overdose. It combines standard paramedic care with free legal help for issues like housing or benefits. Researchers want to see if this reduces drug use and contact with the crimi…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study tests whether a one-visit point-of-care test and treatment package helps more people with hepatitis C finish their care within 24 weeks compared to standard care. About 1,280 participants with or at risk for HIV, hepatitis B, or hepatitis C will take part. The goal is …

This study tests whether tirzepatide, a drug used for diabetes, can lower high brain pressure in people with idiopathic intracranial hypertension (IIH). About 60 adults with IIH will receive either tirzepatide or a placebo for 12 months. The main goal is to see if the drug reduce…

This study tests a new, low-cost tool called KeyScope that helps doctors see inside the belly to diagnose cancer. It is designed for use in places with limited resources, like Uganda. Twelve adults with a suspicious abdominal mass will have a biopsy using this device. The main go…

This study tests whether screening people with early signs of heart disease and giving them medication can prevent the disease from getting worse. About 1,500 adults aged 30-60 with mild plaque in their heart arteries will take either a cholesterol-lowering drug, an anti-inflamma…

This study tests whether phenobarbital, a seizure medication, works as well as standard drugs to calm agitated delirium in ICU adults. Agitated delirium causes confusion and impulsiveness, which can be dangerous. Researchers will compare how long patients stay in the ICU and hosp…

This study tests a home-based eye movement treatment for people with spatial neglect after a stroke. Spatial neglect makes it hard to pay attention to one side of the world, often leading to falls. The treatment uses moving patterns to retrain the brain, and the study will check …

This study tests whether doulas can effectively deliver a program called You Matter to prevent postpartum depression in new mothers. Researchers will enroll 40 pregnant women or new moms with mild depression symptoms. The goal is to see if the program is delivered correctly and i…

This early study tests whether a non-invasive brain stimulation technique called TMS can help reduce pain, fatigue, and brain fog in people with fibromyalgia. About 30 adults will receive multiple TMS sessions and undergo MRI scans to see how the brain changes. The goal is to gat…

This study tests a nurse-led program to help women with HER2+ metastatic breast cancer better understand and manage their treatment. The program includes coaching sessions over 12 weeks to improve symptom control and coping skills. Researchers want to see if the program is practi…

This early-stage study looks at whether metformin, a drug used for diabetes, is safe and tolerable for older adults (65+) with COPD who do not have diabetes. Researchers will also check if metformin changes blood markers linked to aging. The goal is to see if this approach is fea…

This pilot study tests whether a patient decision support tool can help Black and White adults with atrial fibrillation make better-informed choices about blood thinners to prevent strokes. The study enrolls 40 patients and focuses on whether the tool is easy to use and acceptabl…

This study works with epilepsy patients who are already having brain surgery to place tiny, temporary electrodes on the brain's surface. Researchers will measure brain activity while patients do tasks like speaking or remembering, and also during sleep. The goal is to better unde…