Duke University
Clinical trials sponsored by Duke University, explained in plain language.
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Rural school program aims to boost HPV shots for teens
⭐️ VACCINE ⭐️ CompletedThis study tested a school-based program to increase HPV vaccination among middle school students in rural North and South Carolina. Researchers worked with two school districts to see if the program could improve vaccination rates. The study involved only 2 participants and focu…
Phase: NA • Sponsor: Duke University • Aim: ⭐️ VACCINE ⭐️
Last updated Jun 11, 2026 12:11 UTC
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Community health workers help HIV patients control blood pressure
Disease control CompletedThis study looked at whether community health workers can help people with HIV and high blood pressure in northern Tanzania manage their condition. About 100 participants received counseling, doctor visits, and phone calls over 6 months. The goal was to see if this approach helps…
Phase: NA • Sponsor: Duke University • Aim: Disease control
Last updated Jun 11, 2026 12:10 UTC
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Smartphone + nurse = better diabetes control?
Disease control CompletedThis study tested whether using mobile monitoring devices along with nurse support can help people better manage type 2 diabetes and high blood pressure. 220 adults with poorly controlled diabetes took part. Researchers measured changes in blood sugar and blood pressure over time…
Phase: NA • Sponsor: Duke University • Aim: Disease control
Last updated Jun 11, 2026 11:57 UTC
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Weekly shot may halt arthritis progression in kids
Disease control CompletedThis study tested whether a weekly injection of abatacept, given for 24 weeks, could prevent juvenile idiopathic arthritis (JIA) from spreading to more joints or causing eye inflammation. It included 121 children aged 2 to 16 with mild JIA (affecting 4 or fewer joints). The goal …
Phase: PHASE3 • Sponsor: Duke University • Aim: Disease control
Last updated Jun 08, 2026 13:18 UTC
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Free produce program shows promise for diabetes patients facing food insecurity
Disease control CompletedThis study looked at whether giving diabetes patients who are at risk for food insecurity gift cards for fruits and vegetables, along with nutrition education, could improve their blood sugar control and reduce emergency room visits. Over 2,000 adults from a diabetes registry too…
Phase: NA • Sponsor: Duke University • Aim: Disease control
Last updated Jun 08, 2026 13:07 UTC
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New app aims to ease emotional burden of glaucoma
Symptom relief CompletedThis study tested a mobile app designed to help people with glaucoma manage feelings of distress, anxiety, and depression. The app uses techniques from a type of therapy called Acceptance and Commitment Therapy (ACT). Researchers worked with 28 patients and 5 health professionals…
Phase: NA • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 11, 2026 12:10 UTC
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Cash and companionship: a new way to ease mental distress?
Symptom relief CompletedThis study tested whether small cash grants and peer mentoring could help transgender people who are struggling financially feel less psychological distress. 360 transgender adults experiencing material hardship were split into three groups: one got a single grant, another got mo…
Phase: NA • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 11, 2026 12:10 UTC
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New hope for long COVID sufferers: sleep study targets insomnia and fatigue
Symptom relief CompletedThis study tested different treatments to help people with Long COVID who have trouble sleeping. Researchers wanted to see if targeting specific sleep issues, like feeling very sleepy during the day or having trouble falling asleep, could improve sleep and daily life. About 470 a…
Phase: PHASE2 • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 11, 2026 12:09 UTC
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New therapy offers hope for the emotional toll of infertility
Symptom relief CompletedThis study looked at whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help people struggling with the emotional stress of infertility. Nine adults with infertility took part in 12 therapy sessions. Researchers wanted to see if patients found the t…
Phase: NA • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 11, 2026 11:57 UTC
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New online program helps lupus patients fight fatigue and brain fog
Symptom relief CompletedThis study tested an 8-session online health coaching program called WHEEL for 36 women with lupus. The program helps participants set personal health goals and address symptoms like fatigue, pain, and brain fog that often aren't covered in regular doctor visits. The study measur…
Phase: NA • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 09, 2026 12:14 UTC
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Lung transplant patients walk farther, worry less with coping and exercise program
Symptom relief CompletedThis study tested a program that combines coping skills training with exercise for people who have had a lung transplant. 180 adults were split into two groups: one received the coping and exercise program, the other got standard care and education. The goal was to see if the pro…
Phase: NA • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 08, 2026 13:16 UTC
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Hope for teens with Never-Ending headaches: new drug shows promise
Symptom relief CompletedThis study looked at children and teens aged 10-18 who have a constant headache every day (called New Daily Persistent Headache). Researchers gave them a monthly injection of a medicine that blocks a protein linked to headaches (CGRP) and checked if their headaches got better. Th…
Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 08, 2026 13:12 UTC
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New pain block may beat epidural for colon surgery recovery
Symptom relief CompletedThis study tested whether a quadratus lumborum (QL) block—a numbing injection between abdominal muscle layers—provides better pain control and easier recovery than the standard epidural for people having laparoscopic colon surgery. Researchers measured opioid use and pain scores …
Phase: PHASE4 • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 08, 2026 13:09 UTC
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New pain coping training eases daily struggles for advanced cancer patients
Symptom relief CompletedThis study tested a program called Meaning-Centered Pain Coping Skills Training (MCPC) for people with advanced solid tumor cancer who have pain. 211 patients were randomly assigned to either the MCPC program or standard care. The program taught skills to help pain interfere less…
Phase: NA • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 08, 2026 13:07 UTC
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New study aims to ease exercise struggles for long COVID sufferers
Symptom relief CompletedThis study tested different methods to help people with Long COVID who have trouble exercising or feel very tired after activity. About 300 adults who developed these symptoms after a COVID-19 infection took part. Researchers compared approaches like structured pacing to see if t…
Phase: NA • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 08, 2026 13:03 UTC
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Sleep therapy may protect hearts of PTSD patients
Knowledge-focused CompletedThis study looked at whether treating insomnia can reduce the risk of heart disease in people with PTSD. Researchers measured blood pressure, blood vessel health, and other heart risk factors in 140 adults aged 40-59. The goal was to see if improving sleep could also improve hear…
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 11, 2026 12:11 UTC
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Tiny trial tracks germs from mom to baby
Knowledge-focused CompletedThis study looked at how a skin treatment for mothers before childbirth might change the amount of Staph aureus bacteria on their skin and how it spreads to their newborns. Only one participant was involved, and researchers also asked about interest and willingness to use the tre…
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 11, 2026 12:11 UTC
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Can a simple doctor chat boost medication adherence in rheumatic disease patients?
Knowledge-focused CompletedThis study tested a program where doctors led a conversation to help patients with chronic rheumatic diseases take their medications as prescribed. The study involved 102 patients and aimed to see if the program was practical and well-received. The goal was to gather information …
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 11, 2026 12:09 UTC
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Kids' weight gain from antipsychotics under Long-Term study
Knowledge-focused CompletedThis study followed over 500 children aged 3 to 18 who were taking risperidone or aripiprazole for years. Researchers measured changes in body mass index (BMI) to understand how these medications affect weight over time. The goal is to better inform doctors and families about the…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 11, 2026 11:57 UTC
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Ketone snacks may buy divers precious minutes against brain seizures
Knowledge-focused CompletedThis study tested whether eating ketone-rich foods before a dive could delay the onset of central nervous system oxygen toxicity—a condition that can cause seizures in divers breathing high-pressure oxygen. Twenty healthy adults exercised in a pressure chamber while breathing pur…
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 10, 2026 13:29 UTC
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New program boosts kidney disease screening in hispanic communities
Knowledge-focused CompletedThis study tested ways to improve kidney disease screening and treatment for Hispanic and Black patients with diabetes. Researchers worked with community groups to screen people and helped clinics provide better care. The goal was to slow kidney disease in these groups and gather…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 09, 2026 12:06 UTC
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New coaching program aims to make hospital talks fairer for black and latinx families
Knowledge-focused CompletedThis study tested a coaching program for doctors to improve how they talk with Black and Latinx families during hospital rounds. The goal was to build trust, respect, and partnership. 51 caregivers and clinicians took part, and researchers measured communication quality, satisfac…
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 08, 2026 13:17 UTC
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New study tests extra heart scans to catch stiff heart early
Knowledge-focused CompletedThis study looked at whether taking extra pictures during a stress echocardiogram (a heart ultrasound during exercise) can help doctors find a condition called heart failure with preserved ejection fraction (HFpEF), or stiff heart, in people with chest pain or shortness of breath…
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 08, 2026 13:12 UTC
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Heart risks linked to brain decline in hispanic Parkinson's patients
Knowledge-focused CompletedThis study looked at why Hispanic people with Parkinson's disease may have more thinking and memory problems. Researchers checked 40 participants for heart-related risks like diabetes, high blood pressure, and obesity. The goal was to understand how these factors might contribute…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 08, 2026 13:05 UTC
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Rosacea cream study: does your moisturizer block your medicine?
Knowledge-focused CompletedThis study looked at whether applying moisturizer before rosacea medication (metronidazole) changes how much medicine gets into the skin. 21 adults with rosacea had the medicine and one of four moisturizers applied to their face. Researchers used gentle tape strips to collect ski…
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 08, 2026 13:05 UTC