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Could a diabetes drug ease brain pressure?

NCT ID NCT07191873

Not yet recruiting Disease control Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can lower brain pressure in people with idiopathic intracranial hypertension (IIH). IIH causes high pressure inside the skull, leading to headaches, ringing in the ears, and vision problems. The trial will involve 60 participants who will receive either tirzepatide or a placebo for about 12 months, and researchers will measure changes in brain pressure and eye health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tirzepatide
What this could lead to
If it works, this could provide a new treatment option to reduce brain pressure and improve symptoms like headaches and vision issues in people with idiopathic intracranial hypertension.
What could go wrong
This is a small, early-phase trial with only 60 participants, so results may not apply to everyone. Tirzepatide can cause side effects like nausea and vomiting, and it's unclear if it will effectively lower brain pressure long-term.

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Conditions

The condition(s) this trial relates to.

Headache pseudotumor cerebri

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC INTRACRANIAL HYPERTENSION (IIH)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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