Less radiation may work just as well for some lymphoma patients

NCT ID NCT03681535

First seen Nov 01, 2025 · Last updated Jun 10, 2026 · Updated 34 times

Summary

This study looks at whether giving a lower dose of radiation (20 Gy instead of 30 Gy) to a smaller area can still keep lymphoma from coming back in patients who had a clear PET scan after chemotherapy. About 241 adults with diffuse large B-cell lymphoma are taking part. The goal is to maintain high local control while reducing side effects.

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Contacts and locations

Locations

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Dana-Farber/Brigham and Women's Cancer Center in clinical affiliation with South Shore Hospital

    Weymouth, Massachusetts, 02190, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Juntendo University

    Tokyo, Japan

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • National Cancer Center of Singapore

    Singapore, Singapore

  • University Hospital Motol

    Prague, Czechia

  • University of Rochester James P. Wilmot Cancer Institute

    Rochester, New York, 14642, United States

  • University of Torino

    Torino, Italy

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Yonsei University Health System

    Seoul, South Korea

Conditions

Explore the condition pages connected to this study.