Could less radiation be just as effective for lymphoma?

NCT ID NCT03681535

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 28 times

Summary

This study looks at whether giving a lower dose of radiation (20 Gy instead of 30 Gy) to a smaller area can still keep lymphoma from coming back after chemotherapy. It involves 241 adults with diffuse large B-cell lymphoma whose PET scans were clear after treatment. The goal is to reduce side effects while maintaining good cancer control.

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Contacts and locations

Locations

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Dana-Farber/Brigham and Women's Cancer Center in clinical affiliation with South Shore Hospital

    Weymouth, Massachusetts, 02190, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Juntendo University

    Tokyo, Japan

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • National Cancer Center of Singapore

    Singapore, Singapore

  • University Hospital Motol

    Prague, Czechia

  • University of Rochester James P. Wilmot Cancer Institute

    Rochester, New York, 14642, United States

  • University of Torino

    Torino, Italy

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Yonsei University Health System

    Seoul, South Korea

Conditions

Explore the condition pages connected to this study.