Duke University

This early-stage study tests a modified herpes virus (MVR-C5252) injected directly into brain tumors in people whose high-grade glioma has come back. The main goals are to check safety and find the best dose. If safe, researchers will also see if it helps control the cancer. Abou…

This study looks at whether giving free fruits and vegetables, plus some extra support like health coaching, can help people with congestive heart failure avoid emergency room visits and hospital stays. About 900 adults with heart failure who also have trouble affording food will…

This study aims to develop better ways to measure eye pressure, which is important for diagnosing and managing glaucoma. Current methods are either subjective or not portable. Researchers will test two new devices on 200 adults and compare them to standard eye pressure tests.

This study tests an online program called UPDOs Protective Styles to help Black women in the southeastern US learn about and start using PrEP, a daily pill that prevents HIV. About 1000 women from 32 beauty salons will either use the program (videos, blogs, and telehealth) or rec…

This pilot study tests whether a supervised, at-home exercise program combining aerobic and strength training is feasible for people recently diagnosed with rheumatoid arthritis (within 6 months). Fifteen participants will follow the program remotely, and researchers will measure…

This study looks at how two types of liver cancer treatments affect patients' quality of life. It includes 78 adults with liver cancer who cannot have surgery. The goal is to see if these treatments help people feel better in their daily lives.

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors struggle with anxiety, depression, and PTSD, but mental health care is hard to access. The app is designed to be used at home, and researc…

This study compares methadone (a long-acting opioid) to standard short-acting opioids like fentanyl for pain relief after cleft palate repair in children aged 6 months to 4 years. The goal is to see if methadone reduces the total amount of pain medicine needed. The trial is curre…

This study tests a program for older adults (65+) with cancer and mild memory issues, along with their spouse or caregiver. Over six video sessions, the pair learn strategies to cope and communicate better. The goal is to see if this approach reduces stress and improves quality o…

This study tests whether using virtual reality (VR) can help patients in the intensive care unit (ICU) become more active and improve their mental well-being. Researchers at Duke University will enroll 60 adults who have been in the ICU for at least 3 days and have limited mobili…

This study looks at how a park-based afterschool program called Fit2Play affects children's physical fitness and mental health. Researchers will analyze data from about 5,000 kids who took part in the program. They will measure changes in weight, blood pressure, fitness tests, an…

This study follows up to 400 people with Pompe disease to track how their immune system reacts to standard enzyme replacement therapy. Researchers will collect medical records from birth to age 18 to learn why some patients develop antibodies that reduce treatment effectiveness. …

This study looks at how common prescription drugs pass into breastmilk and affect breastfed babies. Researchers will measure drug levels in milk and infant blood to estimate how much medication babies receive. The goal is to provide better safety information for the many breastfe…

This study looks at how medications behave in children under 21 who are in the heart intensive care unit. Researchers will collect leftover blood samples and medical data to learn how the body processes these drugs. The goal is to improve dosing and safety for future patients. No…

This study follows 200 adults with glioblastoma, a severe brain cancer, to understand how genetics, immune system, and personal history affect survival and quality of life. Participants fill out online surveys and may provide a blood sample from home. The goal is to gather inform…

This study is a registry that collects information from 300 adults with cancer that has spread to other parts of the body (metastatic cancer). Participants are receiving or have received a special type of high-dose radiation called ablative radiotherapy. The goal is to track shor…

This study looks at how the heart medication digoxin is processed in infants born with a single ventricle heart defect. Researchers will collect blood samples and review medical records from about 20 babies under 6 months old. The study does not change the baby's treatment plan o…

This study explores how aging changes the way our bodies respond to exercise. Researchers will follow up with older adults who completed a structured exercise program up to 15 years ago. They will measure insulin sensitivity, heart and lung fitness, and overall health after a 6-m…

This study looks at how a park-based afterschool program affects the mental health, resilience, physical fitness, and violence prevention of teenagers. Researchers will analyze data from 1,000 teens aged 12-17 in Miami-Dade County. The goal is to see if community programs can imp…

This study enrolls up to 4,000 people who have had liver injury from prescription drugs or herbal supplements. Researchers will collect medical data and use FibroScan tests to track liver health over time. The goal is to build a detailed database to better understand and identify…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures of the back of the eye and is more comfortable than current cameras. About 42 people with and without eye disease will participate.

This study aims to see if a short, sub-maximal exercise test can accurately measure oxygen consumption, compared to a standard questionnaire. Researchers will enroll 100 adults who are scheduled for surgery and can walk. The goal is to improve how doctors assess a patient's fitne…