Duke University

This study tests if transplanting a donated abdominal wall can safely repair large defects in the belly area. It is for people aged 18-65 who need this repair, sometimes along with an organ transplant. The main goal is to see if the transplanted tissue stays healthy after 18 mont…

This study tests whether adding the drug selinexor to standard bispecific antibody therapy can help people with relapsed or refractory multiple myeloma achieve deeper remissions. About 27 adults who have already tried at least 4 prior treatments will take selinexor alongside thei…

This study looks at whether newer CT and ultrasound scans can find fat and scarring in the liver as well as MRI does. About 45 adults with liver disease will get a special CT scan, an MRI, and an ultrasound. The goal is to see if these simpler tests can replace MRI for diagnosis.

This study tests a program called Mindset Moments for young adults (ages 19-25) who have finished cancer treatment. Participants join weekly online group sessions and do short daily activities on an app to help with anxiety and depression. The goal is to see if the program is pra…

This study tests whether a structured nutrition plan helps people recover physical function after abdominal trauma surgery. Participants are adults in the ICU who need nutrition through an IV. They are randomly assigned to either the structured plan (IV nutrition, then shakes for…

This pilot study tests whether a supervised, at-home exercise program combining aerobic and strength training is feasible for people recently diagnosed with rheumatoid arthritis (within 6 months). Researchers will track how well participants stick to the program and whether they …

This study tests a program for older adults (65+) with cancer and mild memory issues, along with their spouse or caregiver. Over six video sessions, the pair learns strategies to manage challenges. The goal is to see if the program reduces distress and improves quality of life. A…

This study tests a program that teaches family caregivers how to help their loved ones with mild to moderate dementia manage chronic pain. Researchers will work with 60 people (30 patients and their caregivers) to see if the training improves pain coping and quality of life. The …

This study tests three different doses of a non-invasive brain stimulation technique called rTMS to see which best improves hand muscle function in people who had a stroke at least three months ago. Researchers will measure changes in brain activity and motor learning after each …

This study aims to find out how common acid reflux symptoms are in children with cystic fibrosis. Researchers will use a symptom questionnaire and, for some children, will stop their reflux medication to see if symptoms get worse. About 20 children aged 2 to 18 will take part.

This study is a registry that will enroll up to 1,000 pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will track their health and pregnancy outcomes to identify risk factors and find ways t…

This study tests a program to help doctors better screen for chronic kidney disease (CKD) in people with type 2 diabetes. Researchers will enroll 750 adults who are missing key lab tests for kidney health. The goal is to see if the program increases the number of patients who get…

This study creates a collection of blood samples from 300 adults with primary or metastatic brain tumors treated at Duke Cancer Center. Researchers will analyze immune cells in the blood to better understand these tumors. The goal is to provide a resource for future studies, not …

This study looks at 200 high-risk pregnant women staying in the hospital. It compares two ways doctors do their daily rounds: the usual way with two visits (early morning and later) versus a single later-morning visit. The goal is to see if one approach makes patients feel better…

This study follows preterm infants with retinopathy of prematurity (ROP), an eye condition that can affect vision for life. Researchers use a special high-speed camera (OCT) to take detailed images of the back of the eye, looking for early signs that may predict vision problems o…

This study looks at how the heart medication digoxin is processed by the bodies of infants born with a single lower heart chamber. Researchers will collect blood samples from 20 babies already prescribed digoxin as part of their routine care. The goal is to learn more about the d…

This study tests a new educational guide to help women with BRCA mutations decide whether to take hormone replacement therapy after having their ovaries and fallopian tubes removed to lower cancer risk. About 50 premenopausal women scheduled for this surgery will receive either t…

This study tests a special toilet device that automatically measures urine and stool output for patients in the hospital. The goal is to see if the device is as accurate as nurses manually measuring output. Participants are adults receiving a stem cell transplant and will use the…