TINNITUS

This study looked for a measurable brain signal (biomarker) that could objectively diagnose chronic tinnitus. Researchers used EEG to record brain activity in 560 adults—some with constant tinnitus and some without. The goal is to replace trial-and-error diagnosis with a personal…

This completed study tested a sound-based therapy for tinnitus (ringing in the ears) in 108 Veterans. Participants used hearing aids that played either notched noise (sound with the tinnitus frequency removed) or broadband white noise. The goal was to see if notched noise could r…

This completed trial tested a personalized sound therapy for adults with chronic tinnitus, a condition where people hear ringing or buzzing without an external source. 25 participants received either music embedded with tones matched to their tinnitus frequency or low-frequency s…

This study tested three non-drug treatments—cognitive behavioral therapy, a breathing exercise, and psychoeducation—to see which best reduces the distress caused by tinnitus (ringing in the ears). Seventy adults with tinnitus were randomly assigned to one of the three approaches.…

This completed trial tested whether combining online acceptance and commitment therapy (ACT) with customized sound therapy helps people with tinnitus and insomnia. 164 adults were split into two groups: one received both therapies, the other only sound therapy. The goal was to se…

This study tested a smartphone app that plays music with a special low-frequency beat (theta auditory beat stimulation) to see if it can reduce the stress and annoyance of tinnitus. 54 adults with chronic tinnitus used the app for 24 minutes a day for 4 weeks. The app's effect wa…

This study tested a special earmuff device that swaps sound from your left ear to your right ear and vice versa, called auditory mirror therapy. Researchers wanted to see if this sound-flipping trick could reduce the distress, loudness, and annoyance of chronic tinnitus. 56 adult…

This study tested a device called Soricle that combines mild nerve stimulation with sound to help people with tinnitus, a condition where you hear ringing or noise in your ears. 36 adults with subjective tinnitus used the device daily for 8 weeks. The goal was to see if it reduce…

This study tested whether two combinations of migraine medications can reduce the impact of moderate-to-severe tinnitus. 78 adults were randomly assigned to receive either nortriptyline plus topiramate, verapamil plus paroxetine, or a placebo. The main goal was to see if these dr…

This completed clinical trial tested whether a dietary supplement called Tisina complex could improve cognitive health in people with mild cognitive impairment and tinnitus. About 84 adults aged 30 to 75 took either the supplement or a placebo for 90 days. Researchers measured ch…

This study tested whether ketamine, a drug that blocks certain brain signals, can help people with tinnitus (ringing in the ears). 42 adults with chronic tinnitus received both ketamine and a placebo on different days. Researchers used brain scans to measure changes in brain chem…

This study tested whether osteopathic manual therapy—gentle hands-on techniques for muscles and joints—can reduce the discomfort and loudness of tinnitus in people whose symptoms change with movement. Fifty-four adults with tinnitus for at least six months received either real os…

This study tested whether playing specific sounds can temporarily reduce the loudness of tinnitus (ringing in the ears). Forty-five adults with chronic tinnitus listened to personalized sound clips for 3 minutes and 20 minutes. Researchers measured how much the tinnitus quieted d…

This pilot study tested a non-invasive white noise device called TinniSoothe in 20 UK veterans with persistent tinnitus. Participants wore the device around their neck during the day and docked it at night for at least one month. The goal was to see if it reduces tinnitus symptom…

This early study tested a new implant device for people with severe tinnitus (ringing in the ears). Nine adults received the implant to see if it was safe and could reduce their symptoms. The study measured side effects and used questionnaires to track changes in tinnitus severit…

This study tested whether injections of incobotulinum toxin A (similar to Botox) into muscles around the ear can relieve tinnitus, a persistent ringing in the ears. Forty-one adults with tinnitus for at least two months received either the drug or a placebo injection. The main go…

This study tested whether combining mild electrical brain stimulation (tRNS) with white noise can temporarily reduce tinnitus symptoms. 35 adults with chronic tinnitus received either the combined treatment or brain stimulation alone. Researchers measured changes in tinnitus loud…

This study tested an herbal compound in 108 adults who had trouble sleeping and tinnitus (ringing in the ears) but did not want to take sleeping pills. Participants took either a low dose, high dose, or placebo daily for 3 months. Researchers measured changes in sleep quality and…

This study tested whether people with tinnitus can tell if they are receiving real or fake ultrasound stimulation of the vagus nerve in the ear. Twenty adults with constant tinnitus for at least six months took part. The goal was to see how well the blinding worked and what side …

This study tested a daily dietary supplement called ACEMg (Soundbites) in 64 adults with hearing loss or tinnitus. Participants took the supplement for 24 weeks and completed hearing tests and symptom surveys at home using a smartphone app. The goal was to see if the supplement c…

This study tested whether an AI-powered chatbot could help people with chronic tinnitus (ringing in the ears). 172 adults used either the chatbot for daily therapy sessions or read educational materials for 30 days. The goal was to see if the chatbot could reduce tinnitus severit…

This study tested a device that gently vibrates the left ear to stimulate the vagus nerve, aiming to reduce the bother of chronic tinnitus. Forty adults with moderate to severe tinnitus used either the active device or a sham (inactive) device during 8 weeks of online mindfulness…

This completed Phase 1 study tested whether olanzapine, an antipsychotic drug, can reduce the discomfort of tinnitus (ringing in the ears). Fifty adults with stable tinnitus for at least 6 months received either olanzapine or a placebo in a crossover design. The main goal was to …

This study tested two online programs—cognitive behavioral therapy (CBT) and mindfulness—to help adults cope with the distress caused by tinnitus (ringing in the ears). 67 participants were randomly assigned to one of the two treatments or a waiting list. The goal was to see if t…

This small study tested a single 6-hour intravenous infusion of brexanolone in 10 adults with tinnitus. The main goal was to check safety and tolerability, while also measuring changes in tinnitus loudness. Results are limited due to the small size and lack of a placebo group.

This study tested whether a special 40 Hz burst of sound can provide longer-lasting relief from tinnitus (ringing in the ears) compared to standard continuous sound therapy. Researchers enrolled 265 adults with chronic tinnitus and used EEG to measure brain activity changes. The …

This study tested whether a brief electrical stimulation of the inner ear could temporarily reduce tinnitus (ringing in the ears) in 25 adults with severe, disruptive tinnitus. Researchers aimed to find the best spot for stimulation to guide development of a future implantable de…

This completed study looked at electronic health records from over 3,300 adults with tinnitus across three hospitals in China. Researchers aimed to identify risk factors and develop models to predict different tinnitus subtypes. The goal is to improve diagnosis and personalized c…