METASTATIC PROSTATE CANCER

This study is testing whether adding one or two common medications (dexamethasone and metronidazole) to a standard prostate cancer drug (abiraterone) can help overcome resistance that sometimes develops. It is for men whose metastatic prostate cancer has stopped responding to abi…

This study is testing whether a cancer vaccine called Sipuleucel-T works better when patients continue taking their standard hormone therapy drugs. It's for men with advanced prostate cancer that has spread but isn't causing major symptoms, and whose PSA levels are rising despite…

This study is testing if adding a second chemotherapy drug, carboplatin, to the standard drug docetaxel can help men with advanced prostate cancer that has stopped responding to hormone therapy. The goal is to see if this combination can slow the cancer's growth and help patients…

This early-stage study is testing a new drug called AZD0516 for men with advanced prostate cancer that has spread. Researchers want to find the safest dose and see if the drug, given alone or with other cancer treatments, can help control the disease. The study will involve about…

This study is testing if a new combination of treatments works better than the current standard for men whose prostate cancer has already spread. It adds a procedure to freeze the prostate and a low-dose chemotherapy pill to the usual hormone-blocking drugs. Researchers want to s…

This study aims to understand how well a targeted radioactive drug works for men with advanced prostate cancer that has spread, in real-world hospital settings across China. It will follow about 170 patients who are already scheduled to receive this treatment, observing their hea…

This study aims to improve safety for cancer patients receiving targeted radiation therapy by having pharmacists review all their medications. Researchers will enroll 600 adults with thyroid cancer, prostate cancer, or neuroendocrine tumors to test whether detailed medication rev…

This study is testing whether an experimental drug called tarlatamab can help control advanced prostate cancer that has spread and stopped responding to standard treatments. The trial will enroll 32 men whose cancer tests positive for a specific protein called DLL3. Researchers w…

This pilot study is testing whether the time of day people take their hormone-based cancer drugs makes a difference. It will enroll 50 people with metastatic breast or prostate cancer and randomly assign them to take their medication either in the morning or the evening. The main…

This is an early-stage study to test the safety and side effects of a new drug, RO7656594, in men with advanced or metastatic prostate cancer that has progressed after standard treatments. The main goals are to find a safe dose and see how the body processes the drug. Researchers…

This study is testing a new treatment called AZD0754 for men whose prostate cancer has spread and is no longer responding to standard therapies. Doctors take a patient's own immune cells, modify them in a lab to target a protein on cancer cells, and then infuse them back into the…

This VA study is testing if adding targeted radiation or surgery to standard drug therapy works better for controlling prostate cancer that has spread to a few spots. It will involve about 464 Veterans whose cancer has returned or spread to 1-10 locations. The goal is to see if t…

This study is testing a new type of PET scan to see if it can better detect aggressive forms of advanced prostate cancer that are difficult to find with current standard scans. Researchers will enroll about 30 men with this specific type of cancer to compare the new scan against …

This study is testing whether a 16-week supervised exercise program can help reduce frailty and muscle loss in men with metastatic prostate cancer who are on hormone therapy. About 80 participants who are already experiencing weakness or frailty will be randomly assigned to eithe…

This study collects blood samples from people with prostate cancer to understand how genetic differences affect the disease. Researchers will analyze DNA from these samples to learn why some prostate cancers stop responding to standard hormone treatments. The goal is to identify …

This study aims to increase the use of a specific genetic test for men with advanced prostate cancer. Researchers will work with both doctors and patients at Johns Hopkins to understand and overcome the reasons why this important test is often not ordered. The goal is to ensure m…