METASTATIC MELANOMA

This small pilot study tested whether combining two different immune-boosting treatments could help control advanced melanoma. Researchers collected cancer-fighting immune cells from patients' tumors, grew them in a lab, and then gave them back along with a drug called ipilimumab…

This study tested whether using a lower dose of the drug ipilimumab together with pembrolizumab could help control melanoma that had spread to the brain. The trial involved 24 patients with this advanced cancer. Researchers wanted to see if this combination was safe and could shr…

This study tested a personalized cell therapy called LN-144 for people with advanced melanoma that had spread and did not respond to prior treatments. Doctors took immune cells from a patient's own tumor, grew large numbers of them in a lab, and then infused them back into the pa…

This study tested a personalized cell therapy for metastatic melanoma, a serious skin cancer. Researchers compared the standard treatment—using a patient's own tumor-fighting white blood cells after chemotherapy—to the same treatment with added total body radiation. The goal was …

This study tested a weekly injection called Taxoprexin in 30 patients with advanced skin melanoma that had spread to other parts of the body. The goal was to see if the treatment could shrink tumors, control the disease, and extend survival. Patients received the injections weekl…

This early-stage study tested a new drug called IN10018, both alone and in combination with other cancer drugs, in 51 adults with advanced melanoma that had spread. The main goal was to check the safety of these treatments and see how the body processes the drug. Researchers also…

This early-stage study tested a personalized vaccine made by combining a patient's own cancer cells with immune cells. The goal was to see if this approach was safe and could train the immune system to attack advanced melanoma. The trial involved 20 patients with spreading melano…

This small, early study tested if combining two immune-boosting treatments could help control advanced melanoma. Seven patients with stage IIIB-IV skin cancer that couldn't be surgically removed received pembrolizumab (an IV drug) and applied imiquimod (a cream) to skin lesions. …

This small, early-stage study tested the safety of combining two treatments for cancer that has spread to the brain: an immunotherapy drug (pembrolizumab) and a very precise form of radiation (stereotactic radiosurgery). The goal was to see if using them together was safe and cou…

This study tested a weekly chemotherapy drug called Taxoprexin in patients whose eye melanoma had spread to other parts of the body. The main goal was to see if the drug could shrink tumors and how long patients lived. It involved 22 participants who received the drug by IV infus…

This study tested a multi-step treatment for advanced melanoma that had spread. Doctors took a patient's own tumor-fighting immune cells, grew billions of them in a lab, and then infused them back. This was combined with a targeted drug and chemotherapy to try to boost the immune…

This study tested a personalized treatment for advanced melanoma that had spread. Doctors took a patient's own cancer-fighting immune cells from a tumor, grew large numbers of them in a lab, and then put them back into the patient's bloodstream. The goal was to see if this approa…

This study tested a special therapy program designed to help people with advanced brain cancer manage the emotional distress that comes with their diagnosis. Researchers compared the therapy, called CALM, to standard care in 60 patients. The main goal was to see if the program wa…

This study aimed to find a better way to predict which patients with advanced skin cancer (metastatic melanoma) would respond well to a common type of immunotherapy. Researchers measured levels of a protein called interferon-gamma in patients' tumors and blood, and also looked at…

This study aimed to understand why some patients with advanced skin cancer (metastatic melanoma) respond well to a type of immunotherapy called anti-PD1, while others do not. Researchers closely tracked changes in patients' immune cells before and during treatment. The goal was t…

This study aimed to compare two different blood test methods for finding melanoma cells that have spread in the body. Researchers tested 73 people, including patients with advanced melanoma and control patients without cancer. The goal was to see which test method was more effect…

This small, early study tested the safety and feasibility of giving a single dose of one of two different drug combinations to patients with melanoma that had spread to the brain. The patients then had surgery to remove the brain tumor 7-10 days later. The main goal was to see if…

This study tested whether a simple blood draw could detect cancer mutations in people with advanced melanoma. Researchers compared the blood test results to traditional tumor biopsies to see if they matched. The goal was to find a less invasive way to guide treatment decisions fo…

This study observed 400 adults in Europe with advanced, hard-to-treat skin cancer (melanoma) who were already receiving standard targeted drug therapy. The goal was to learn about these patients and understand how they used a specific mobile app (TavieSkin) designed to support th…

This study aimed to understand how the immune system changes in people with advanced melanoma who are receiving immunotherapy drugs (nivolumab with or without ipilimumab). Researchers closely monitored the immune cells in the blood and skin of 5 patients to identify differences b…