Supercharged immune cells take on advanced melanoma in new trial
NCT ID NCT02360579
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tested a personalized cell therapy called lifileucel for people with advanced melanoma that had spread and stopped responding to standard treatments. Researchers took immune cells from each patient's tumor, multiplied them in a lab, and infused them back after mild chemotherapy. The study enrolled 220 participants and measured how many patients' tumors shrank or disappeared.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lifileucel (a personalized cell therapy made from a patient's own immune cells that attack the tumor)
What this could lead to
If successful, this could offer a new treatment option for people with advanced melanoma that has stopped responding to other therapies.
What could go wrong
This is a phase 2 trial, so results are still early. The treatment involves intensive chemotherapy beforehand and may cause serious side effects. Not all patients will respond.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Addenbrooke's Hospital
Cambridge, CB2 0QQ, United Kingdom
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Atlantic Health System
Morristown, New Jersey, 07960, United States
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Beatson West of Scotland Cancer Centre
Glasgow, Scotland, G12 0YN, United Kingdom
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California Pacific Medical Center
San Francisco, California, 94115, United States
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Centre Hospitalier Lyon Sud
Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France
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Centre Hospitalier Universitaire Vaudois Lausanne - Centre Pluridisciplinaire d'Oncologie
Lausanne, Switzerland
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Centre Léon Bérard
Lyon, Auvergne-Rhône-Alpes, 69008, France
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Centro di Riferimento Oncologico di Aviano
Aviano, Pordenone, 33081, Italy
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Clínica Universidad de Navarra
Pamplona, Navarre, 31008, Spain
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Consorci Hospital General Universitari de València
Valencia, Spain
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Gustave Roussy Cancer Campus
Villejuif, Île-de-France Region, 94805, France
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HM Centro Integral Oncológico Clara Campal
Madrid, 28050, Spain
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Hospital 12 de Octubre
Madrid, 28041, Spain
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Hospital Clinic de Barcelona
Barcelona, 08036, Spain
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Hospital General Universitario Gregorio Marañon
Madrid, 28007, Spain
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Hospital Universitari Vall d'Hebrón
Barcelona, 08035, Spain
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Hospital Universitario Quirónsalud Madrid
Madrid, 28233, Spain
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Hôpital Dupuytren
Limoges, Limousin, 87042, France
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Indiana University
Indianapolis, Indiana, 46202-5116, United States
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Inselspital
Bern, 3010, Switzerland
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Institut Català d'Oncologia
Barcelona, 08907, Spain
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Istituto Europeo di Oncologia
Milan, 20141, Italy
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Istituto Nazionale Tumori IRCCS Fondazione Pascale
Naples, 80131, Italy
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Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
Meldola, Forli-cesena, 47014, Italy
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Istituto di Candiolo - Fondazione del Piemonte per l'Oncologia
Candiolo, Torino, 10060, Italy
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James Graham Brown Cancer Center
Louisville, Kentucky, 40202, United States
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Klinikum Rechts der Isar der Technischen Universität München
München, Bavaria, 81675, Germany
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida, 33140, United States
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New York University Langone Medical Center
New York, New York, 10016, United States
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Providence Cancer Center Oncology and Hematology Care Clinic
Portland, Oregon, 97213, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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Royal Marsden NHS Trust
London, England, SW3 6JJ, United Kingdom
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Rutgers University
New Brunswick, New Jersey, United States
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Sarah Cannon Research Institute London
London, W1G 6AD, United Kingdom
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Seattle Cancer Care Alliance
Seattle, Washington, 98109, United States
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Szegedi Tudomanyegyetem Szent-Györgyi Albert Klinikai Központ
Szeged, Csongrád megye, 6720, Hungary
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The Angeles Clinic and Research Institute
Los Angeles, California, 90048, United States
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Thomas Jefferson University
Philadelphia, Pennsylvania, 19701, United States
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Universitaetsklinikum Heidelberg
Heidelberg, Baden-Wurttemberg, 69120, Germany
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Universitaetsklinikum Tuebingen (UKT) - Suedwestdeutschen Tumorzentrum - Zentrum für Neuroonkologie
Tübingen, Baden-Wurttemberg, 72076, Germany
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University of California Los Angeles - David Geffen School of Medicine - Westwood Rheumatology
Los Angeles, California, 90095, United States
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University of California San Diego Moores Cancer Center
La Jolla, California, 92093, United States
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University of Colorado Cancer Center
Aurora, Colorado, 80049, United States
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University of Florida Health Cancer Center
Orlando, Florida, 32806, United States
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University of Miami
Miami, Florida, 33136, United States
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University of Minnesota, Masonic Cancer Center
Minneapolis, Minnesota, 55455, United States
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University of Pittsburgh Medical Center - Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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University of South Florida H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612, United States
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Universitätsklinikum Carl Gustav Carus
Dresden, Saxony, Germany
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Universitätsklinikum Erlangen
Erlangen, Bavaria, 91052, Germany
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Universitätsklinikum Halle
Halle, Saxony-Anhalt, 06120, Germany
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Universitätsklinikum Leipzig
Leipzig, Saxony, 4103, Germany
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Universitätsklinikum Schleswig-Holstein - Campus Lübeck
Lübeck, Schleswig-Holstein, 23538, Germany
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Universitätsklinikum Würzburg
Würzburg, 97080, Germany
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Virginia Commonwealth University
Richmond, Virginia, 23298, United States
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Yale Cancer Center
New Haven, Connecticut, 06510, United States