METASTATIC MELANOMA

This early-phase trial tested a specially modified virus (VSV-IFNbetaTYRP1) in 12 people with advanced melanoma that had spread or could not be removed. The virus was injected directly into tumors and into a vein to see if it could safely trigger the immune system to attack cance…

This study tested two drugs, bintrafusp alfa and pimasertib, in people whose cancer had spread to the brain. The goal was to find the best dose and see if the combination could slow or stop tumor growth. The trial was stopped early after enrolling only 8 participants, so no clear…

This early-phase trial tested a drug called STI-3031, given directly into the lymph nodes or vessels using a special device, for people with in-transit melanoma (cancer that has spread through lymph channels but not yet to distant organs). The main goals were to find the safest d…

This early-stage study tested a new drug called PF-08046031 in 11 adults with advanced melanoma or other solid tumors that had spread or no longer responded to standard treatments. The main goal was to check the drug's safety and side effects. The study was terminated early, so r…

This study tested whether adding an experimental drug (CMP-001) injected directly into tumors to the standard immunotherapy nivolumab works better than nivolumab alone for people with advanced melanoma that cannot be removed by surgery or has spread. The trial was stopped early a…

This study tested a combination of two drugs, pembrolizumab and lenvatinib, in 18 adults with melanoma or kidney cancer that had spread to the brain. All participants had already been treated with similar immunotherapy drugs. The goal was to see if the combination could shrink br…

This early-stage trial tested whether adding a device that creates electric fields (NovoTTF-200M) to standard radiation and immunotherapy could safely treat melanoma that has spread to the brain. Only 1 person took part before the study was stopped. The main goal was to check for…