Personalized cell therapy shows promise for Hard-to-Treat cancers

NCT ID NCT03645928

Terminated Disease control Sponsor: Iovance Biotherapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen May 22, 2026 · Last updated Jun 14, 2026 · Updated 3 times

Summary

This study tested a treatment that uses a patient's own immune cells (called TIL) taken from their tumor, grown in a lab, and then given back to fight the cancer. It included 225 adults with advanced melanoma, head and neck cancer, or non-small cell lung cancer. The goal was to see if this approach could shrink tumors and how safe it was.

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Contacts and locations

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Locations

Attikon University General Hospital

Athens, Attica, 12461, Greece
Centre Hospitalier Universitaire Vaudois

Lausanne, 1011, Switzerland
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Georgetown University Medical Center

Washington D.C., District of Columbia, 20007, United States
Guy's Hospital

London, England, SE19RT, United Kingdom
Henry Ford Health System

Detroit, Michigan, 48202, United States
Hospital Regional Universitario de Malaga - Hospital General

Málaga, Málaga, 29016, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28040, Spain
Hospital Universitario HM Sanchinarro

Madrid, 28050, Spain
Hospital Universitario Marques de Valdecilla

Santander, Cantabria, 39008, Spain
ICO l'Hospitalet - Hospital Duran i Reynals

Barcelona, 08908, Spain
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Laiko General Hospital of Athens

Athens, Attica, 11527, Greece
MD Anderson at Cooper

Camden, New Jersey, 08103, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Morristown Medical Center

Morristown, New Jersey, 07960, United States
Ohio State University

Columbus, Ohio, 43201, United States
Orlando Health Cancer Institute

Orlando, Florida, 32610, United States
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2C1, Canada
The Royal Marsden NHS Foundation Trust

London, England, SW3 6JJ, United Kingdom
Universitaetsspital Bern

Bern, 3010, Switzerland
University of California, Los Angeles

Los Angeles, California, 90095, United States
University of California, San Diego

La Jolla, California, 92093, United States
University of Cincinnati

Cincinnati, Ohio, 45219, United States
University of Colorado

Denver, Colorado, 80045, United States
University of Louisville

Louisville, Kentucky, 40292, United States
University of Maryland

Baltimore, Maryland, 21201, United States
University of Southern California

Los Angeles, California, 90007, United States
Universitätsklinikum Schleswig-Holstein - Campus Lübeck

Lübeck, Schleswig-Holstein, 23538, Germany
Yale University

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

METASTATIC MELANOMA NON-SMALL CELL LUNG CANCER SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK