IDIOPATHIC PULMONARY FIBROSIS

This study tested an oral drug called GRI-0621 in 35 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing problems. The drug aims to reduce scarring by blocking certain immune cells (NKT1 cells). Participants took either the drug or a…

This study tested an experimental pill, BI 1015550, in over 1,100 adults with idiopathic pulmonary fibrosis (IPF), a progressive lung-scarring disease. Participants took either the drug or a placebo twice daily for at least a year, while some continued their usual IPF medications…

This study tested an experimental drug called GKT137831 in 58 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and makes breathing difficult. The drug aims to reduce lung damage caused by harmful molecules called reactive oxygen species. Resear…

This early study tested whether injecting stem cells from donated umbilical cords is safe for people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Seventeen adults aged 40-75 took part. The main goal was to check for side effec…

This study tested an experimental drug called MN-001 in 15 people with moderate to severe idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing problems. For 6 months, some participants received the drug and others received a placebo (a dummy pill…

This study tested a new tablet called HSK44459 in 186 adults aged 40 and older with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The goal was to see if the drug could improve lung function over 12 weeks compared to a placebo. Resea…

This study tested a daily oral drug called TTI-101 in 100 people with idiopathic pulmonary fibrosis (IPF), a lung disease that causes scarring and breathing problems. The main goal was to see if the drug is safe and tolerable over 12 weeks. Researchers also measured how the drug …

This study tested whether adding N-acetylcysteine (NAC) to standard care helps people with idiopathic pulmonary fibrosis (IPF) who have a specific gene variant (TOLLIP TT). The goal was to see if NAC could delay lung function decline, hospital stays, or death. 202 adults with IPF…

This early-stage study tested a new medicine called BI 1015550 in 15 people with idiopathic pulmonary fibrosis (IPF) who were not taking other treatments. The main goal was to see if the drug is safe and tolerable. Researchers also measured how the drug moves through the body. Th…

This early-stage study tested a new drug, HuL001, in 24 people to see if it is safe and how the body processes it. The trial included both healthy volunteers and patients with idiopathic pulmonary fibrosis, a serious lung disease that causes scarring. Researchers monitored side e…

This early-stage study tested an inhaled drug called ARO-MMP7 in 105 people, including healthy volunteers and patients with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. The main goal was to check safety and how the drug moves …

This study tested three different doses of an experimental oral medicine, BI 1819479, against a placebo in 322 adults aged 40 and older with idiopathic pulmonary fibrosis (IPF). Participants took the treatment for 6 to 12 months, and doctors measured lung function through breathi…

This study tested a new drug called PLN-74809 in 10 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring. The goal was to see if the drug could reduce scarring in the lungs over 12 weeks. Participants took either the drug or a placebo, and doctors …

This study tested a cell therapy called REGEND001 for people with idiopathic pulmonary fibrosis (IPF), a serious lung-scarring disease. 23 adults received either the cell treatment or a placebo to see if it could improve lung function. The therapy uses special lung cells that may…

This study tested whether an inhaled medication called treprostinil could help people with idiopathic pulmonary fibrosis, a progressive lung scarring disease. 598 participants either received the active medication or a placebo inhaler for 52 weeks to see if it could slow the decl…

This study tested the safety of a purified green tea extract called EGCG in 50 people with idiopathic pulmonary fibrosis (IPF), a lung scarring disease. Participants took EGCG or a placebo daily for 12 weeks. The main goal was to see if EGCG is safe and how it interacts with stan…

This study tested whether low-dose morphine can reduce coughing in people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. 44 adults with chronic cough took either morphine or a placebo for 14 days, then switched. The goal was to see if morphine lowered daytime …

This study tested an experimental drug called orvepitant to see if it could reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. About 80 adults with IPF and a persistent cough that didn't respond to other treatments took part. Part…

This study looked at whether a device that delivers gentle thumps to the lungs (intrapulmonary percussion ventilation) can help inhaled medication reach scarred areas in people with idiopathic pulmonary fibrosis (IPF). Nine participants inhaled a harmless radioactive tracer with …

This study looked at 178 people with advanced cancer, chronic kidney disease, or serious lung conditions to find out when they need palliative care. Researchers used special scores to predict survival and guide care. No new treatments were tested; instead, the goal was to learn h…

This study tested a special PET scan that can detect collagen, a protein that builds up in scarred lungs. The goal was to see if this scan could measure the effect of a green tea extract called EGCG in people with idiopathic pulmonary fibrosis (IPF). Twelve participants who were …

This completed study looked at over 10,000 people in France with idiopathic pulmonary fibrosis to see how long they stayed on antifibrotic medication. The goal was to measure the percentage still taking the drug after 30 months and find reasons why some stop early. No direct trea…