BARIATRIC SURGERY

This study looks at what happens to the body after bariatric surgery in people aged 12 to 24. It also tests whether adding semaglutide (a weekly injection) can help those who haven't lost enough weight 1 to 2 years after surgery. The goal is to understand why some respond better …

This study tests a modified version of sleeve gastrectomy, a common weight-loss surgery, to see if it can reduce or prevent acid reflux (GERD) that often occurs after the standard procedure. About 44 adults with obesity and GERD will be randomly assigned to receive either the sta…

This study tests whether a 16:8 time-restricted eating diet (eating only during an 8-hour window each day) helps people with obesity manage their weight, both those who have had bariatric surgery and those who haven't. Researchers will measure changes in body weight, fat mass, an…

This study tests whether taking tirzepatide (Mounjaro/Zepbound) for three months before bariatric surgery reduces inflammation and leads to better weight loss and fewer complications. Fifty adults with obesity scheduled for surgery will either receive the drug or standard diet an…

This study tests whether a special diet that promotes a diverse gut microbiome can help people lose more weight and keep it off after bariatric surgery. Sixty adults aged 25-65 who are scheduled for weight-loss surgery will be randomly assigned to receive either standard nutritio…

This study tests whether a program of breathing muscle training and exercise can improve lung function, exercise capacity, and sleep in people who recently had bariatric surgery. Researchers will enroll 52 adults aged 18 to 60. Participants will do supervised breathing exercises …

This study tests a new magnetic device that creates a shortcut in the small intestine, aiming to help control type 2 diabetes and weight. Only 5 people will take part to see if the procedure is safe and feasible. It is an early-stage trial, so the main goal is to check if the mag…

This study tests whether a supervised exercise program after bariatric surgery helps patients maintain muscle mass and bone density. Researchers will compare two groups of 54 adults who had gastric bypass or sleeve surgery: one group will follow a structured exercise plan, the ot…

This study tests a new way to follow patients after weight-loss surgery. Instead of yearly check-ups, patients use a connected scale at home, and doctor visits are scheduled based on weight changes. The goal is to see if this personalized approach helps patients maintain weight l…

This study tests whether taking whey protein and collagen supplements along with doing resistance exercises can help people keep their muscle mass after bariatric surgery. About 35 adults who are having the surgery will be split into groups to compare different combinations of su…

This study tests a new, personalized version of a weight-loss surgery called SADI-S. Surgeons will measure each patient's small intestine and adjust the bypass length to maximize weight loss while lowering the risk of vitamin deficiencies. The study includes 40 adults with obesit…

This study tests whether taking daily protein supplements and doing resistance exercises (like lifting weights) can prevent too much muscle loss after bariatric surgery. About 400 patients will be randomly assigned to either standard care or standard care plus the protein and exe…

This study compares two surgical options for people with severe obesity and acid reflux (GERD). Half of the 560 participants will get a newer procedure called Nissen-Sleeve Gastrectomy, which combines stomach reduction with a reflux barrier; the other half will get the standard R…

This study tests whether giving an intravenous iron infusion three days before bariatric surgery can prevent anemia and improve quality of life in obese patients with iron deficiency. Researchers will enroll 200 participants and compare those who receive iron to those who get a p…

This study tests whether adding dramatherapy—using role play, improvisation, and creative exercises—to a standard exercise program improves quality of life for adults with obesity and eating disorders. Participants are in medical or bariatric care and will be randomly assigned to…

This study tests if a mild electrical patch placed on the skin (called TENS) can prevent breathing problems after weight-loss surgery in people with severe obesity. About 70 participants will be randomly assigned to receive either TENS or a fake device. The main goal is to see if…

This study tests whether starting gentle, supervised movement soon after bariatric surgery and continuing it at home can help manage pain and improve recovery. Researchers will track pain levels, physical function, and quality of life in 112 participants. The goal is to find a si…

This study tests whether adding suzetrigine, a new non-opioid pain drug, to standard pain management can lower the amount of opioids needed after weight-loss or heart surgery. About 235 adults will be randomly assigned to receive either suzetrigine or a placebo alongside usual ca…

This study tests two drugs—lidocaine and dexmedetomidine—given as infusions during laparoscopic sleeve gastrectomy to see which one helps with pain and recovery. Forty adults aged 20-50 with a BMI of 35-50 are being recruited. The goal is to find a better way to manage early post…

This study tests whether an ultrasound-guided nerve block called M-TAPA can reduce pain and the need for opioid painkillers after laparoscopic sleeve gastrectomy. Sixty adults scheduled for this weight-loss surgery will receive the block while under anesthesia. Researchers will m…

This study follows 80 adults before and after bariatric surgery to see how their muscle mass, strength, and physical function change over time. Researchers use ultrasound to measure thigh muscle thickness and simple tests like handgrip strength and walking speed. The goal is to b…

This study follows 165 adults undergoing bariatric surgery to see if certain pre-surgery traits—like anxiety, depression, eating behaviors, and weight-related quality of life—can predict how their quality of life changes over the two years after surgery. Participants complete que…

This study looks at how gut bacteria affect blood sugar control after bariatric (weight-loss) surgery. Researchers will compare patients having sleeve gastrectomy, gastric bypass, gallbladder removal, or pancreas sampling. By analyzing stool and blood samples, they hope to unders…

This study is recruiting 100 adults with obesity to find out what factors predict weight loss after taking weight-loss drugs or having bariatric surgery. Researchers will track participants over time, measuring things like eating behaviors, thinking skills, and biological markers…

This observational study looks at the bacteria in dental plaque of 170 people with obesity (BMI 30+) who are scheduled for bariatric surgery. Researchers want to see if the types and amounts of mouth bacteria differ between those with obesity (BMI 30-35) and those with morbid obe…

This study looks at the best dose of a green fluorescent dye (indocyanine green) used during repeat weight-loss surgery to see blood flow. About 108 people with obesity scheduled for this surgery will get different doses of the dye. The goal is to find the smallest dose that stil…

This study tests two ways of using a breathing machine during weight-loss surgery in people with obesity. One method controls the flow of air, the other controls the volume. Researchers will measure oxygen levels and airway pressures to see which approach keeps lungs working bett…

This study looks at how severe obesity and weight-loss surgery change natural chemicals in scalp hair. Researchers will track 60 adults—some with severe obesity scheduled for bariatric surgery and some healthy-weight controls—to see if hair chemistry can signal poor metabolic hea…

This study looks at how digestion works in people who have had bariatric surgery (like gastric bypass or sleeve gastrectomy) and in people living with obesity. Researchers will collect fluid samples from the stomach and small intestine, and also use a swallowable capsule that mea…

This study is tracking 2000 adults who are having weight-loss (bariatric) surgery to learn what factors influence their pain and daily functioning afterward. Researchers will use patient questionnaires to measure pain, side effects, and long-term recovery. The goal is to better u…

This study looks at 200 adults who need a second weight-loss surgery (revision bariatric surgery) to see if using a robot or standard laparoscopy leads to fewer complications. The main focus is on problems like leaks, bleeding, and infections. Researchers will also compare pain, …