Sudden arrhythmia death syndrome

This study tests whether adding an implantable cardioverter defibrillator (ICD) to standard medication helps people with variant angina who have survived a sudden cardiac arrest. About 140 adults will be randomly assigned to get either an ICD plus medication or medication alone. …

This study tests whether emergency responders can safely use a special cooling vest on adults who have had a cardiac arrest and regained a pulse but remain unconscious. The vest is designed to cool the body quickly in the ambulance, which might protect the brain. The goal is to s…

This study is testing whether people aged 70 and older with heart failure and a weak heart pump live just as long with only medication as they do with an implanted defibrillator (ICD). The trial will randomly assign 730 participants to receive either an ICD plus medication or med…

This study compares a new pacing method (left bundle branch pacing) with a standard pacemaker-defibrillator in 30 people who have hypertrophic cardiomyopathy and a specific heart block after myectomy surgery. The goal is to see if the new method better prevents heart failure wors…

This study compares two common heart failure medications, carvedilol and metoprolol succinate, in 2,000 adults who have an implantable cardioverter defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol…

This study compares two types of portable heart monitors in people who have symptoms of an irregular heartbeat (arrhythmia) but whose standard heart test was normal. About 588 participants will wear either a continuous ECG patch or use a handheld ECG device for one month. The goa…

This study evaluates a new multichannel ECG system designed to detect early signs of cardiovascular disease (CVD) in people who may have no symptoms yet. The system uses advanced algorithms to analyze electrical signals from the heart, looking for subtle abnormalities that could …

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study aims to improve how doctors diagnose a rare heart condition where a coronary artery starts in the wrong place (AAOCA), which can cause sudden cardiac death in young athletes. Researchers will use artificial intelligence and 3D computer models to analyze CT scans and pr…

This study compares two approaches for heart attack survivors with weak hearts: taking modern medications alone versus getting a defibrillator implant plus medications. The goal is to see if medication alone is as good at preventing sudden cardiac death. About 3,600 participants …

This study tests a modified imaging catheter (ViewFlex X ICE) to help doctors see heart structures during procedures for irregular heartbeats. About 500 adults who are already scheduled for a heart procedure using ultrasound will be enrolled. The goal is to see if the new cathete…

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which treats abnormal heart rhythms. Researchers will ask 200 children aged 5 to 17 and their parents to fill out questionnaires about physical, emotional, social, and schoo…

This study watches people with blood cancers like CLL who take BTK inhibitors or venetoclax to see how these drugs affect heart rhythm. Researchers will use EKGs, stress tests, and heart monitors to track abnormal rhythms and sudden death risk. The goal is to better understand an…

This study will collect ECG recordings from 600 people using the HeartBeam 3-Lead ECG recorder. The goal is to build a database of heart rhythm information for future research and regulatory use. Participants will have their ECG taken as part of routine care, and their de-identif…

This study aims to understand why some people with epilepsy die suddenly (SUDEP). Researchers will measure how well patients sense carbon dioxide in their blood and how seizures affect breathing and heart function. 335 adults with epilepsy will be followed for up to 10 years. The…

This study aims to create a North American registry of sudden unexplained death in epilepsy (SUDEP) cases. Researchers will interview family members and review medical records of people with epilepsy who died suddenly. By comparing these cases with living epilepsy patients, they …

This study is looking for new genes and blood markers linked to arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can lead to heart failure and sudden cardiac arrest. Researchers will enroll 1,000 people, including patients with AVC or unexplained cardiac arrest…

This study aims to create a tool that uses stress heart MRI and routine medical data to predict which patients with dilated cardiomyopathy (a weakened, enlarged heart) are at highest risk for serious problems like heart failure or sudden cardiac death. Researchers will follow 2,0…

This study looks at tiny particles called exosomes in the blood of 300 people who experienced sudden cardiac death after a heart attack. Researchers want to see if certain molecules in these particles can help predict who is at highest risk. The goal is to improve early warning a…

This study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…

This study will implant a small heart monitor (loop recorder) in 20 young adults aged 18-60 who have a heart condition called mitral annular disjunction and mild or no symptoms. The goal is to detect hidden dangerous heart rhythms that could lead to sudden cardiac death. Particip…

This study is observing 1,500 people with coronary artery disease to find better ways to predict who is at risk of sudden cardiac arrest. Researchers are looking at genetic, electrical, and biological markers, as well as psychological factors. The goal is to identify high-risk pa…

This study looks at whether MRI scans can help predict serious heart events in people who have implanted heart devices like pacemakers or defibrillators. Researchers will scan 1,500 adults before they get their device and track their health for years. The goal is to see if MRI fi…

This study follows 1500 people who already have an implantable cardioverter-defibrillator (ICD) to prevent sudden cardiac death. Researchers will track heart function, genetics, and blood markers to find better ways to predict who is at highest risk. The goal is to improve how do…

This study is testing whether advanced MRI and CT scans can identify people at highest risk for sudden cardiac death. Researchers will follow 400 participants who have low heart function and are scheduled to receive an implantable defibrillator. The goal is to see if these imagin…

This study is testing a special heart monitor, the BIOMONITOR IV, in 300 people with heart failure who also have irregular heartbeats. The device tracks heart activity, fluid levels, and breathing patterns to see if it can predict when heart failure gets worse. Researchers hope t…