Renal infectious disease

This study tested two DNA vaccines designed to prevent hemorrhagic fever with renal syndrome caused by Hantaan and Puumala viruses. A total of 132 healthy adults received up to four doses of vaccine using a needle-free jet injector. The main goal was to see if the vaccines trigge…

This study tested whether switching from one immunosuppressant to everolimus, along with lowering overall immunosuppression, helps clear BK virus better than just lowering immunosuppression alone. The trial involved 130 kidney transplant recipients with BK virus in their blood. T…

This study tested a new antibiotic combination, cefepime-zidebactam, against a standard antibiotic (meropenem) in adults hospitalized with complicated urinary tract infections or kidney infections. About 530 participants received either the new drug or the standard one for 7 to 1…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This study looked at 38 kidney transplant patients who had CMV infection. Researchers wanted to see if measuring a type of immune cell (γδ T cells) could help decide who needs extra medication to prevent the virus from coming back. The goal is to avoid unnecessary drugs while sti…

This study tested two new antibiotic combinations (cefepime/nacubactam and aztreonam/nacubactam) against the best available treatments for adults with serious infections like urinary tract infections, pneumonia, and abdominal infections caused by carbapenem-resistant bacteria. Th…

This study tested an oral antibiotic (tebipenem pivoxil hydrobromide) against a standard IV antibiotic in 1,690 hospitalized adults with complicated urinary tract infections or kidney infections. The goal was to see if the oral pill works as well as the IV treatment in curing the…

This phase 3 trial tested two new antibiotic combinations—cefepime/nacubactam and aztreonam/nacubactam—against a standard antibiotic (imipenem/cilastatin) in 614 adults with complicated urinary tract infections or acute kidney infections. The goal was to see if the new combos are…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested an antibody drug called AntiBKV in 95 kidney transplant patients with BK virus infection. The virus can damage the new kidney if not controlled. Patients received four doses of the drug or a placebo over four months. The goal was to see if the drug could clear t…

This pilot study tested whether women with kidney infections could safely stop antibiotics once their symptoms resolved, instead of taking a full 10-day course. 35 women were randomly assigned to either standard treatment or a patient-directed approach. The main goal was to see i…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a new wearable patch that collects sweat to measure sodium and creatinine levels, which are important for monitoring kidney health and dehydration. Five adults with kidney disease wore the patch while their sweat was analyzed using a special light-based techniqu…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested whether giving intravenous immunoglobulins (IVIG) could prevent BK virus infection in kidney transplant recipients. The virus often causes graft problems. Researchers enrolled 359 patients with low antibody levels against their donor's virus strain and gave some…

This completed study looked at 378 kidney transplant patients to see if measuring antibodies against BK virus before transplant could predict whether the virus would reactivate after surgery. Researchers used a lab-made virus-like particle to test for five different BK virus type…

This study looked at 172 kidney transplant recipients who were on stable anti-rejection medication for at least 3 months. Researchers measured levels of a common, harmless virus (Torque Teno Virus) in their blood to see if it could predict serious infections or organ rejection. T…

This study looked at whether a blood test that measures immune response to CMV can predict infection risk in children who have received a heart, kidney, or liver transplant. Researchers tested blood samples from 161 children within the first year after transplant. The goal is to …

This study tested whether adding infectious disease experts to primary care teams helps reduce unnecessary antibiotic use. Over 1,300 patients from six clinics in Spain took part. Doctors in the expert-advised group could call or meet with specialists to discuss tricky cases. The…

This study looked at whether levels of a common virus called Torque teno virus (TTV) can help doctors monitor how well a kidney transplant patient's immune system is suppressed. The goal is to find a simple blood test that could predict rejection or infection. Researchers followe…

This study reviewed 575 adults admitted to intensive care for a severe kidney infection called acute obstructive pyelonephritis. Researchers aimed to identify factors that lead to poor outcomes such as death or lasting kidney damage. The goal is to better understand which patient…

This study looked at whether a special blood test could predict BK virus infection in people who had a kidney transplant. The test measured how certain immune cells (T cells) react to the virus. Researchers studied 80 kidney transplant recipients to see if this test could help ca…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …