Posterior corneal dystrophy

This study tests a single injection of AURN001 in 120 adults with corneal swelling caused by endothelial dysfunction. The goal is to see if it improves vision and reduces corneal thickness compared to a placebo. Participants must already have an artificial lens in the eye and be …

This study compares two surgical approaches for Fuchs endothelial dystrophy, a condition that clouds the cornea. One is a full corneal transplant (DMEK), the other is a simpler procedure that removes only the diseased cells (DSO) plus Ripasudil eye drops to help healing. 60 parti…

This study tests whether giving a laser treatment (transscleral cyclophotocoagulation) to lower eye pressure before a Boston keratoprosthesis (a plastic cornea implant) can prevent or slow glaucoma. Twenty adults who need the implant will receive one of two laser types 4-8 weeks …

This study tests whether briefly soaking a donor cornea in a solution made from the patient's own blood (PRGF) before transplant surgery can reduce the loss of important cells after the operation. About 100 people with Fuchs' endothelial dystrophy or corneal swelling will take pa…

This study compares two types of cornea transplant surgery—DSAEK and DMEK—in 220 adults with corneal swelling or Fuchs' dystrophy. The goal is to see which procedure leads to better vision and patient satisfaction one year after surgery. Participants will be randomly assigned to …

This study tests a new way to treat a detached Descemet's membrane, a rare complication after cataract surgery. Fifty patients aged 50-70 will be split into two groups: one gets a standard air injection into the eye, and the other gets a modified technique that first deflates the…

This early-stage trial tests a new implant called PVEK for people with corneal swelling from Fuchs' dystrophy or pseudophakic bullous keratopathy. The implant uses a collagen scaffold with human corneal cells to replace damaged tissue. About 15 participants will receive the impla…

This study tests an experimental eye drop called DT-168 in people with Fuchs endothelial corneal dystrophy who are already scheduled for a corneal transplant. The goal is to see if the drops are safe and affect disease-related markers. About 28 adults aged 30 and older with a spe…

This early-stage trial tests the safety of injecting special human cells (EO2002) into the eye to treat corneal swelling. Twelve adults with corneal edema from Fuchs' dystrophy or after cataract surgery will receive multiple injections, with or without Ripasudil eye drops. The ma…

This study tests a new, gentler steroid eye drop plan after corneal transplant surgery. The goal is to prevent rejection while reducing side effects like high eye pressure. About 342 adults getting a DMEK transplant will be followed for two years to see if a milder steroid works …

This phase 2 trial is testing whether N-acetyl cysteine (NAC) eye drops can reduce oxidative stress in the eyes of people with Fuchs endothelial corneal dystrophy (FECD), a condition that often leads to corneal transplant. The study will enroll 45 adults with advanced FECD who ar…

This early-stage trial tests a new type of corneal graft made from lab-grown human cells. It is for people with mild to moderate corneal damage from conditions like Fuchs' dystrophy or after eye surgery. The goal is to see if the graft is safe and can improve vision. 30 participa…

This study is testing a new eye imaging device called the VG200D, which uses advanced technology to take detailed pictures of the eye. Researchers want to see if it works as well as a standard device for measuring parts of the eye in people with glaucoma, retina problems, corneal…

This study is testing a new imaging technique called Brillouin microscopy to see if it can diagnose keratoconus and other corneal thinning conditions. Researchers will scan the corneas of 168 volunteers, including healthy people and those with keratoconus or post-LASIK ectasia, t…

This study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…

This study will compare how well patients see after three types of corneal transplants: DSAEK, UT-DSAEK, and DMEK. Researchers will follow 1,000 people who had surgery for Fuchs' endothelial corneal dystrophy or pseudophakic bullous keratopathy. They will measure vision, cell cou…

This study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …

This study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…

This study looks at whether polishing the inner layer of the cornea before injecting new cells helps remove tiny bumps called guttae in people with Fuchs endothelial corneal dystrophy. Twenty adults scheduled for corneal transplant will have half their cornea polished and the oth…

This study is looking at how genes relate to the different forms of Fuchs corneal endothelial dystrophy, a common eye disease that affects the cornea. Researchers in France will enroll 500 people who need corneal transplant surgery. They will analyze blood samples for genetic mar…

This long-term study collects data from over 100 eye clinics in Germany to see how corneal transplant surgeries have changed since 2001. Researchers track the number of surgeries, the types of procedures used, and the reasons people need them. The goal is to understand trends, no…

This study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…

This study gathers eye scan images from 180 people with healthy eyes or eye diseases like glaucoma and retinal disease. The goal is to collect data using a new optical coherence tomography (OCT) device called A10900. No treatment or medication is given. The information will help …

This study compares lying on your back for 1 day versus 5 days after a specific type of corneal transplant (DMEK) for Fuchs dystrophy. Researchers want to see if a longer period helps the transplant stay attached and reduces the need for extra procedures. About 102 participants w…

This study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…

This study is testing a scoring system called the SUCCESS Score to see if it can predict which people with Fuchs dystrophy will need a cornea transplant after cataract surgery. Researchers will follow 250 adults who have both Fuchs dystrophy and cataracts. The goal is to improve …

This study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…

This study involves 135 adults getting a cornea transplant. Surgeons will use a new method to check the health of donor eye tissue before surgery. The goal is to see if this check helps predict how well the transplant will work long-term, reducing the chance of graft failure.

This study uses a special eye scan called OCT to measure swelling in the cornea of people with Fuchs' dystrophy or a related condition. Researchers want to see if this scan can predict how vision changes after surgery. About 60 participants will be observed over time.