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Posterior corneal dystrophy
MONDO:0020214Posterior corneal dystrophies refers to a group of rare genetically determined corneal dystrophies (CDs) characterized by lesions affecting the corneal endothelium and Descemet membrane, and variable effects on vision depending on the type of dystrophy.
43 clinical trials for this condition and its sub-types.
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New eye drops aim to speed vision recovery after cornea surgery
Disease control CompletedThis study tested whether ripasudil eye drops can help people with Fuchs endothelial corneal dystrophy recover vision faster after a specific cornea procedure called descemetorhexis. The trial involved 107 adults and compared the drops to a placebo over 12 weeks of treatment, fol…
Phase: PHASE3 • Sponsor: Kowa Research Institute, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New eye drops aim to speed vision recovery after cornea surgery
Disease control CompletedThis study tested whether ripasudil eye drops can help people with Fuchs endothelial corneal dystrophy recover vision faster after combined cataract and cornea surgery. 110 adults received either the eye drops or a placebo for 12 weeks, followed by a taper and 38-week follow-up. …
Phase: PHASE3 • Sponsor: Kowa Research Institute, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Eye surgery showdown: which cornea transplant is safer?
Knowledge-focused CompletedThis study compared two types of cornea transplant surgery (DSAEK and DMEK) for people with Fuchs' endothelial dystrophy, a condition that clouds the cornea. Researchers measured vision and tracked side effects like swelling and eye pressure in 112 participants. The goal was to f…
Phase: NA • Sponsor: University of Aarhus • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Does donor diabetes impact corneal transplant outcomes?
Knowledge-focused CompletedThis completed study looked at whether diabetes in a cornea donor affects the success of a corneal transplant called DMEK. Over 1,000 participants received a cornea from either a donor with or without diabetes. Researchers tracked graft failure and cell loss for one year to see i…
Phase: NA • Sponsor: Case Western Reserve University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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New registry aims to improve corneal transplants with AI
Knowledge-focused CompletedThis study created a nationwide registry to track long-term results of corneal surgeries and diseases. Researchers collected images and data from 19 participants to help understand what makes corneal transplants successful. The goal is to use this information to develop AI that c…
Sponsor: Nitin Vaswani • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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AI eye chatbot matches doctors in taking patient history
Knowledge-focused CompletedThis study tested whether a large language model (like ChatGPT) could collect medical history and suggest eye tests as well as doctors do. 172 patients with non-emergency eye problems took part. The AI's performance was compared to standard care, with senior specialists checking …
Phase: NA • Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC