Peripheral nervous system disorder
MONDO:0003620A disease involving the peripheral nervous system.
Also known as: PNS (peripheral nervous system) diseases, PNS disease, PNS diseases, disease of peripheral nervous system, disease or disorder of peripheral nervous system, disorder of peripheral nervous system, disorder of the peripheral nervous system, peripheral nervous system disease
2293 clinical trials for this condition and its sub-types, 121 tagged with Peripheral nervous system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Peripheral nervous system disorder
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Peripheral neuropathy 93 trials · 1,473 incl. sub-types
30 sub-types
- Hereditary peripheral neuropathy 6 trials · 479 incl. sub-types Sub-types →
- Neuralgia 238 trials · 384 incl. sub-types Sub-types →
- Nerve compression syndrome 24 trials · 207 incl. sub-types Sub-types →
- Diabetic neuropathy 182 trials · 193 incl. sub-types Sub-types →
- Chemotherapy-induced neuropathy 171 trials
- Polyneuropathy 32 trials · 133 incl. sub-types Sub-types →
- Mononeuropathy 4 trials · 112 incl. sub-types Sub-types →
- Acquired peripheral neuropathy 0 trials · 95 incl. sub-types Sub-types →
- Nerve plexus disorder 0 trials · 75 incl. sub-types Sub-types →
- Sensory peripheral neuropathy 4 trials · 58 incl. sub-types Sub-types →
- Traumatic neuropathy 55 trials
- Neuritis 18 trials · 29 incl. sub-types Sub-types →
- Peripheral nerve lesion 1 trial · 12 incl. sub-types Sub-types →
- Autonomic neuropathy 7 trials · 10 incl. sub-types Sub-types →
- Chronic idiopathic neuropathy 5 trials
- Axonal neuropathy 1 trial · 4 incl. sub-types Sub-types →
- Neuropathy, small fiber 4 trials
- Infectious neuropathy 2 trials
- Vasculitic neuropathy 2 trials
- Autoimmune neuropathy 1 trial
- Idiopathic small fibers neuropathy 1 trial
- Ischemic neuropathy 1 trial
- Motor peripheral neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Radiation-induced neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Sarcoid neuropathy 1 trial
- Neuropathy in cryoglobulinemia 0 trials
- Neuropathy in endocrine disorder 0 trials
- Paraproteinemia-associated neuropathy 0 trials
- Uremic neuropathy 0 trials
- Vitamin deficiency related neuropathy 0 trials
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Autonomic nervous system disorder 59 trials · 209 incl. sub-types
13 sub-types
- Dysautonomia 16 trials · 64 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Sympathetic nervous system disorder 8 trials · 28 incl. sub-types Sub-types →
- Pure autonomic failure 18 trials
- Autonomic dysreflexia 11 trials
- Autonomic neuropathy 7 trials · 10 incl. sub-types Sub-types →
- Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease 5 trials
- Baroreflex failure 1 trial
- Frey syndrome 0 trials
- Chronic hiccup 0 trials
- Harlequin syndrome 0 trials
- Idiopathic peripheral autonomic neuropathy 0 trials
- Parasympathetic nervous system disorder 0 trials Sub-types →
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Peripheral nervous system neoplasm 3 trials · 197 incl. sub-types
9 sub-types
- Nerve sheath neoplasm 8 trials · 123 incl. sub-types Sub-types →
- Peripheral nervous system cancer 0 trials · 67 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Cranial nerve neoplasm 0 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of peripheral nervous system 0 trials Sub-types →
- Mediastinal neural neoplasm 0 trials Sub-types →
- Nerve plexus neoplasm 0 trials Sub-types →
- Nerve root neoplasm 0 trials Sub-types →
- Peripheral ganglioneuroblastoma 0 trials Sub-types →
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Autoimmune disorder of peripheral nervous system 0 trials · 195 incl. sub-types
4 sub-types
- Myasthenia gravis 159 trials · 160 incl. sub-types Sub-types →
- Guillain-Barre syndrome 23 trials · 39 incl. sub-types Sub-types →
- Autoimmune neuropathy 1 trial
- Autoimmune optic neuritis 0 trials
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Radiculopathy 163 trials
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Third cranial nerve disorder 1 trial · 87 incl. sub-types
2 sub-types
- Oculomotor nerve paralysis 1 trial · 87 incl. sub-types Sub-types →
- Oculomotor nerve neoplasm 0 trials Sub-types →
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Trigeminal nerve disorder 3 trials · 63 incl. sub-types
4 sub-types
- Trigeminal neuralgia 37 trials
- Trigeminal autonomic cephalalgia 8 trials · 27 incl. sub-types Sub-types →
- Ophthalmic herpes zoster 0 trials
- Trigeminal nerve neoplasm 0 trials Sub-types →
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Facial nerve disorder 4 trials · 53 incl. sub-types
9 sub-types
- Bell's palsy 29 trials Sub-types →
- Facial neuralgia 16 trials
- Clonic hemifacial spasm 4 trials
- Facial hemiatrophy 3 trials
- Mobius syndrome 2 trials Sub-types →
- Melkersson-Rosenthal syndrome 0 trials
- Facial nerve neoplasm 0 trials
- Geniculate ganglionitis 0 trials
- Isolated facial myokymia 0 trials
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Neuroma 20 trials · 27 incl. sub-types
2 sub-types
- Morton neuroma 7 trials
- Multiple mucosal neuroma 0 trials
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Olfactory nerve disorder 8 trials · 12 incl. sub-types
1 sub-type
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
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Vestibulocochlear nerve disorder 2 trials · 11 incl. sub-types
2 sub-types
- Vestibular neuronitis 9 trials
- Vestibulocochlear nerve neoplasm 0 trials Sub-types →
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Glossopharyngeal nerve disorder 2 trials · 8 incl. sub-types
5 sub-types
- Vagus nerve disorder 4 trials Sub-types →
- Glossopharyngeal neuralgia 2 trials
- Glossopharyngeal motor neuropathy 0 trials
- Glossopharyngeal nerve neoplasm 0 trials Sub-types →
- Glossopharyngeal nerve paralysis 0 trials
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Cauda equina syndrome 2 trials
1 sub-type
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Abducens nerve disorder 0 trials · 2 incl. sub-types
2 sub-types
- Abducens nerve palsy 2 trials
- Abducens nerve neoplasm 0 trials
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Accessory nerve disorder 1 trial
1 sub-type
- Spinal accessory nerve neoplasm 0 trials
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Hypoglossal nerve disorder 1 trial
1 sub-type
- Hypoglossal nerve neoplasm 0 trials Sub-types →
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Trochlear nerve disorder 1 trial
2 sub-types
- Fourth cranial nerve palsy 1 trial Sub-types →
- Trochlear nerve neoplasm 0 trials
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Peroneal nerve paralysis 0 trials
Most studied deeper sub-types
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New bladder cancer drug aims to fight tumors without harming nerves
Disease control Not yet recruitingThis phase II trial compares a new targeted drug, sacituzumab tirumotecan (Sac-TMT), to other antibody-drug conjugates (ADCs) in people with advanced urothelial carcinoma (bladder cancer) that has worsened after prior treatment. The main goal is to see if Sac-TMT causes less seve…
Phase 2 • Sponsor: Fudan University • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Could siliconepads replace foam to protect diabetic feet?
Disease control Not yet recruitingThis study compares two types of foot pads—siliconepads and felted foam—to see which one better reduces pressure under the ball of the foot in people with diabetes who are at high risk for foot ulcers. Researchers will measure pressure relief and ask participants about comfort an…
Sponsor: University Hospital, Ghent • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Nerve signal test may forecast treatment success in rare nerve disease
Diagnosis Not yet recruitingAnti-MAG neuropathy is a rare nerve condition that can cause disability, and treatments like rituximab or IVIg work differently for each person. Researchers are studying whether a simple nerve test, the Terminal Latency Index (TLI), can predict who will respond well to treatment.…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Diagnosis
Last updated Sep 02, 2026 00:00 UTC
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New study aims to catch diabetic nerve damage earlier with advanced testing
Diagnosis Not yet recruitingThis study looks at how well nerve tests and ultrasound can detect diabetic peripheral neuropathy, a common complication of diabetes that causes pain and numbness in the feet. Researchers will compare results from 75 adults with diabetes and healthy volunteers to see which tests …
Sponsor: Assiut University • Aim: Diagnosis
Last updated Jun 27, 2026 08:07 UTC
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Acupuncture needles aim to stop Chemo's nerve pain
Prevention Not yet recruitingThis study tests whether electroacupuncture (using mild electric pulses on needles) plus tiny thumbtack needles can prevent nerve damage caused by chemotherapy in people with early-stage cancer. About 278 patients with breast, stomach, bowel, lung, or ovarian cancer will receive …
Sponsor: Affiliated Hospital of Qinghai University • Aim: Prevention
Last updated Jun 27, 2026 14:01 UTC
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Acupuncture with a jolt: could needles shield nerves from chemo?
Prevention Not yet recruitingThis study tests whether electroacupuncture (acupuncture with mild electrical pulses) combined with tiny thumbtack needles can prevent peripheral neuropathy—numbness, tingling, or pain—caused by chemotherapy in people with advanced cancer. The trial enrolls adults with stage IV b…
Sponsor: Affiliated Hospital of Qinghai University • Aim: Prevention
Last updated Jun 27, 2026 13:06 UTC
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Hope for cancer patients: simple drug combo may prevent Chemo-Induced nerve pain
Prevention Not yet recruitingThis study tests whether two existing drugs—memantine (used for Alzheimer's) and rosuvastatin (a cholesterol-lowering statin)—can prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with colorectal cancer. About 46 adults will receive these drugs alongside …
Phase 2/3 • Sponsor: Tanta University • Aim: Prevention
Last updated Jun 27, 2026 12:02 UTC
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Could light therapy ease Chemo's nerve pain?
Symptom relief Not yet recruitingThis trial investigates whether photobiomodulation (low-level laser light) can reduce early nerve damage caused by chemotherapy. About 98 cancer patients with early signs of peripheral neuropathy will receive either light therapy or a placebo. The goal is to see if this non-invas…
Sponsor: Jules Bordet Institute • Aim: Symptom relief
Last updated Jul 04, 2026 00:00 UTC
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Could hand therapy replace surgery for carpal tunnel?
Symptom relief Not yet recruitingThis study tests if a combination of manual therapy and nerve stimulation can relieve symptoms of moderate carpal tunnel syndrome as well as surgery recovery does. About 150 adults aged 30-50 with confirmed moderate carpal tunnel will be split into two groups: one gets the non-su…
Sponsor: Universidad Europea de Valencia • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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New study tests Nerve-Saving support for bladder cancer patients
Symptom relief Not yet recruitingThis study looks at whether a supportive product called Neuridase can help reduce nerve damage (peripheral neuropathy) caused by a combination of two cancer drugs (enfortumab vedotin and pembrolizumab) in people with advanced bladder cancer. About 40 participants will receive sta…
Sponsor: University of Florence • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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New device hopes to boost leg blood flow in veterans with PAD and nerve damage
Symptom relief Not yet recruitingThis study tests whether using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will have their blood flow measured before and after treatmen…
Sponsor: Indiana University • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Shockwaves may soothe heel pain in neuropathy patients
Symptom relief Not yet recruitingThis study tests whether extracorporeal shockwave therapy (ESWT) can reduce pain and improve daily function in people with peripheral neuropathy who also have plantar fasciitis (heel pain). About 114 adults will receive either real or sham shockwave treatment. The goal is to see …
Phase 2 • Sponsor: National Taiwan University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Simple exercises may soothe chemo nerve damage
Symptom relief Not yet recruitingThis study tests whether a 15-minute hand and foot exercise routine can reduce nerve pain caused by Taxane chemotherapy in cancer patients. Fifty-eight adults with mild nerve symptoms will either do the exercises plus standard care or receive standard care alone. Researchers will…
Sponsor: University of Health Sciences Lahore • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Could a worm enzyme soothe diabetic nerve damage?
Symptom relief Not yet recruitingThis study tests whether an oral supplement called DLBS1033 (made from earthworm proteins) can reduce nerve damage symptoms in adults with diabetic polyneuropathy. Thirty-four people with type 2 diabetes will receive either the supplement or a placebo for 28 days, alongside stand…
Phase 2/3 • Sponsor: Universitas Sebelas Maret • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Night splints for carpal tunnel: which angle works best?
Symptom relief Not yet recruitingThis study compares three different wrist splint positions (flexed, neutral, and extended) worn at night for eight weeks in 108 adults with mild to moderate carpal tunnel syndrome. All participants also receive education and exercises. The goal is to see which position best reduc…
Sponsor: Istanbul University • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Exercise may ease Chemo's nerve pain, new study hopes to prove
Symptom relief Not yet recruitingThis study looks at whether exercise can lessen nerve damage caused by certain chemotherapy drugs. About 140 people with colorectal or gynecologic cancer will either exercise or receive usual care. Researchers will measure nerve function, blood markers, and quality of life to see…
Sponsor: National Cancer Center, Korea • Aim: Symptom relief
Last updated Jun 27, 2026 09:03 UTC
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Simple hand and foot moves may ease chemo nerve pain in older cancer patients
Symptom relief Not yet recruitingThis study looks at whether hand and foot exercises can reduce nerve pain (numbness, tingling) and improve quality of life in adults aged 65+ with gynecological cancer who are on chemotherapy. About 74 participants will do these exercises to see if they help with chemotherapy sid…
Sponsor: Taipei Veterans General Hospital, Taiwan • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Exercise program aims to ease breast cancer side effects
Symptom relief Not yet recruitingThis study tests a 3-month exercise program for women with breast cancer who have arm swelling (lymphedema) and nerve pain (neuropathy) from treatment. Thirty women will do general and arm-specific exercises twice a week. Researchers will measure changes in arm size and pain leve…
Sponsor: Universitat Internacional de Catalunya • Aim: Symptom relief
Last updated Jun 26, 2026 18:29 UTC
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Hidden nerve damage may worsen life for ankylosing spondylitis patients
Knowledge-focused Not yet recruitingThis study will check 45 adults with ankylosing spondylitis for peripheral neuropathy (nerve damage in the arms and legs) using nerve conduction tests. Researchers want to see if nerve problems are linked to higher disease activity, increased pain sensitivity, and worse quality o…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Wearable sensors could transform CMT1A monitoring
Knowledge-focused Not yet recruitingThis study will use wearable activity trackers to measure how much people with Charcot-Marie-Tooth disease type 1A (CMT1A) move at home. Researchers want to see if sensor data matches standard clinical tests. The goal is to improve patient follow-up and support future trials of n…
Sponsor: University Hospital, Limoges • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC