Peripheral nerve lesion

This study tests whether giving a 10-minute electrical stimulation to a repaired finger nerve during surgery can speed up healing and improve sensation. Sixty adults aged 18-80 with a cut digital nerve will receive either standard surgical repair alone or with added electrical st…

This phase 2 trial tests whether tesamorelin, a daily self-injected drug, can speed nerve regrowth and reduce muscle loss after surgical repair of injured nerves in the arm. 36 adults with a cut ulnar nerve at the wrist will be randomly assigned to receive tesamorelin or no addit…

This study compares two treatments for long blockages (15-25 cm) in the leg's main artery. One is bypass surgery, which uses a vein or artificial tube to reroute blood flow. The other is a less invasive procedure using a balloon to open the artery, often with a stent. The trial w…

This study tests a device called Walkasins, worn on the lower legs, that vibrates to give sensory feedback about foot pressure. The goal is to see if using it daily for six months improves balance and walking in 200 adults aged 55+ with peripheral neuropathy. Participants will do…

This study tests if low-level laser therapy can reduce pain and improve quality of life in people with meralgia paresthetica, a condition causing numbness or burning on the outer thigh. About 44 adults will receive either real laser or a sham laser, both combined with TENS (a mil…

This study tests whether adding high-power laser therapy to standard care (like lifestyle changes and pain medication) can better relieve pain, tingling, and numbness in people with meralgia paresthetica—a nerve condition causing discomfort in the outer thigh. About 50 adults wit…

This study aims to see if a quick bedside sensory test can predict which painkiller—pregabalin, duloxetine, or a placebo—works best for people with nerve pain in their feet. About 190 adults with diabetic, chemotherapy-related, or idiopathic nerve pain will try each treatment for…

This study is collecting information from 4,000 adults with peripheral neuropathy (nerve damage) to better understand the condition. Researchers will combine standard tests with nerve ultrasound to see if it helps diagnose and track the disease. No new treatments are being tested…

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms …