Median nerve neuropathy

This study looks at whether taking a small piece of ligament during routine carpal tunnel surgery can help diagnose transthyretin amyloidosis, a serious condition that often goes unnoticed until it affects the heart. Researchers will compare this new biopsy method to the standard…

This study tests a device called Walkasins, worn on the lower legs, that vibrates to give sensory feedback about foot pressure. The goal is to see if using it daily for six months improves balance and walking in 200 adults aged 55+ with peripheral neuropathy. Participants will do…

This study tests a gel called DYNAVISC placed around the nerve during repeat carpal tunnel surgery to see if it reduces pain and tingling better than standard surgery alone. About 50 adults with ongoing hand pain after a prior carpal tunnel release will take part. Results are mea…

This study compares two treatments for carpal tunnel syndrome: an ultrasound-guided injection around the nerve versus a small-incision surgery to relieve pressure. Researchers will measure pain and hand function in 60 adults with mild to severe symptoms over 12 weeks. The goal is…

This study tests a new brace that applies small, repeated forces to the wrist during sleep, aiming to relieve carpal tunnel syndrome symptoms. Researchers will compare it to a standard brace in 116 adults. The main goal is to see if the device reduces pain and improves hand funct…

This study tests whether pain neuroscience education (PNE) can improve symptoms in people with mild to moderate carpal tunnel syndrome. Participants will receive PNE along with standard home exercises and a wrist splint. The goal is to see if understanding pain better leads to le…

This study aims to see if a quick bedside sensory test can predict which painkiller—pregabalin, duloxetine, or a placebo—works best for people with nerve pain in their feet. About 190 adults with diabetic, chemotherapy-related, or idiopathic nerve pain will try each treatment for…

This study looks at how carpal tunnel syndrome (CTS) severity relates to sleep quality. Researchers will compare 120 CTS patients with healthy controls using ultrasound and sleep questionnaires. The goal is to better understand the connection between nerve compression and poor sl…

This study is collecting information from 4,000 adults with peripheral neuropathy (nerve damage) to better understand the condition. Researchers will combine standard tests with nerve ultrasound to see if it helps diagnose and track the disease. No new treatments are being tested…

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms …