Peripheral nervous system disorder
MONDO:0003620A disease involving the peripheral nervous system.
Also known as: PNS (peripheral nervous system) diseases, PNS disease, PNS diseases, disease of peripheral nervous system, disease or disorder of peripheral nervous system, disorder of peripheral nervous system, disorder of the peripheral nervous system, peripheral nervous system disease
2293 clinical trials for this condition and its sub-types, 121 tagged with Peripheral nervous system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Peripheral nervous system disorder
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Peripheral neuropathy 93 trials · 1,473 incl. sub-types
30 sub-types
- Hereditary peripheral neuropathy 6 trials · 479 incl. sub-types Sub-types →
- Neuralgia 238 trials · 384 incl. sub-types Sub-types →
- Nerve compression syndrome 24 trials · 207 incl. sub-types Sub-types →
- Diabetic neuropathy 182 trials · 193 incl. sub-types Sub-types →
- Chemotherapy-induced neuropathy 171 trials
- Polyneuropathy 32 trials · 133 incl. sub-types Sub-types →
- Mononeuropathy 4 trials · 112 incl. sub-types Sub-types →
- Acquired peripheral neuropathy 0 trials · 95 incl. sub-types Sub-types →
- Nerve plexus disorder 0 trials · 75 incl. sub-types Sub-types →
- Sensory peripheral neuropathy 4 trials · 58 incl. sub-types Sub-types →
- Traumatic neuropathy 55 trials
- Neuritis 18 trials · 29 incl. sub-types Sub-types →
- Peripheral nerve lesion 1 trial · 12 incl. sub-types Sub-types →
- Autonomic neuropathy 7 trials · 10 incl. sub-types Sub-types →
- Chronic idiopathic neuropathy 5 trials
- Axonal neuropathy 1 trial · 4 incl. sub-types Sub-types →
- Neuropathy, small fiber 4 trials
- Infectious neuropathy 2 trials
- Vasculitic neuropathy 2 trials
- Autoimmune neuropathy 1 trial
- Idiopathic small fibers neuropathy 1 trial
- Ischemic neuropathy 1 trial
- Motor peripheral neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Radiation-induced neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Sarcoid neuropathy 1 trial
- Neuropathy in cryoglobulinemia 0 trials
- Neuropathy in endocrine disorder 0 trials
- Paraproteinemia-associated neuropathy 0 trials
- Uremic neuropathy 0 trials
- Vitamin deficiency related neuropathy 0 trials
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Autonomic nervous system disorder 59 trials · 209 incl. sub-types
13 sub-types
- Dysautonomia 16 trials · 64 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Sympathetic nervous system disorder 8 trials · 28 incl. sub-types Sub-types →
- Pure autonomic failure 18 trials
- Autonomic dysreflexia 11 trials
- Autonomic neuropathy 7 trials · 10 incl. sub-types Sub-types →
- Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease 5 trials
- Baroreflex failure 1 trial
- Frey syndrome 0 trials
- Chronic hiccup 0 trials
- Harlequin syndrome 0 trials
- Idiopathic peripheral autonomic neuropathy 0 trials
- Parasympathetic nervous system disorder 0 trials Sub-types →
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Peripheral nervous system neoplasm 3 trials · 197 incl. sub-types
9 sub-types
- Nerve sheath neoplasm 8 trials · 123 incl. sub-types Sub-types →
- Peripheral nervous system cancer 0 trials · 67 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Cranial nerve neoplasm 0 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of peripheral nervous system 0 trials Sub-types →
- Mediastinal neural neoplasm 0 trials Sub-types →
- Nerve plexus neoplasm 0 trials Sub-types →
- Nerve root neoplasm 0 trials Sub-types →
- Peripheral ganglioneuroblastoma 0 trials Sub-types →
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Autoimmune disorder of peripheral nervous system 0 trials · 195 incl. sub-types
4 sub-types
- Myasthenia gravis 159 trials · 160 incl. sub-types Sub-types →
- Guillain-Barre syndrome 23 trials · 39 incl. sub-types Sub-types →
- Autoimmune neuropathy 1 trial
- Autoimmune optic neuritis 0 trials
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Radiculopathy 163 trials
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Third cranial nerve disorder 1 trial · 87 incl. sub-types
2 sub-types
- Oculomotor nerve paralysis 1 trial · 87 incl. sub-types Sub-types →
- Oculomotor nerve neoplasm 0 trials Sub-types →
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Trigeminal nerve disorder 3 trials · 63 incl. sub-types
4 sub-types
- Trigeminal neuralgia 37 trials
- Trigeminal autonomic cephalalgia 8 trials · 27 incl. sub-types Sub-types →
- Ophthalmic herpes zoster 0 trials
- Trigeminal nerve neoplasm 0 trials Sub-types →
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Facial nerve disorder 4 trials · 53 incl. sub-types
9 sub-types
- Bell's palsy 29 trials Sub-types →
- Facial neuralgia 16 trials
- Clonic hemifacial spasm 4 trials
- Facial hemiatrophy 3 trials
- Mobius syndrome 2 trials Sub-types →
- Melkersson-Rosenthal syndrome 0 trials
- Facial nerve neoplasm 0 trials
- Geniculate ganglionitis 0 trials
- Isolated facial myokymia 0 trials
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Neuroma 20 trials · 27 incl. sub-types
2 sub-types
- Morton neuroma 7 trials
- Multiple mucosal neuroma 0 trials
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Olfactory nerve disorder 8 trials · 12 incl. sub-types
1 sub-type
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
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Vestibulocochlear nerve disorder 2 trials · 11 incl. sub-types
2 sub-types
- Vestibular neuronitis 9 trials
- Vestibulocochlear nerve neoplasm 0 trials Sub-types →
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Glossopharyngeal nerve disorder 2 trials · 8 incl. sub-types
5 sub-types
- Vagus nerve disorder 4 trials Sub-types →
- Glossopharyngeal neuralgia 2 trials
- Glossopharyngeal motor neuropathy 0 trials
- Glossopharyngeal nerve neoplasm 0 trials Sub-types →
- Glossopharyngeal nerve paralysis 0 trials
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Cauda equina syndrome 2 trials
1 sub-type
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Abducens nerve disorder 0 trials · 2 incl. sub-types
2 sub-types
- Abducens nerve palsy 2 trials
- Abducens nerve neoplasm 0 trials
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Accessory nerve disorder 1 trial
1 sub-type
- Spinal accessory nerve neoplasm 0 trials
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Hypoglossal nerve disorder 1 trial
1 sub-type
- Hypoglossal nerve neoplasm 0 trials Sub-types →
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Trochlear nerve disorder 1 trial
2 sub-types
- Fourth cranial nerve palsy 1 trial Sub-types →
- Trochlear nerve neoplasm 0 trials
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Peroneal nerve paralysis 0 trials
Most studied deeper sub-types
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Could a lower dose of an old antibiotic tame Drug-Resistant TB?
Disease control CompletedThis study tests whether a low daily dose of the antibiotic linezolid, added to a personalized combination of other drugs, is safe and tolerable for people with multidrug-resistant tuberculosis (MDR-TB). Participants take either linezolid or a placebo for 16 weeks, alongside thei…
Phase 1/2 • Sponsor: Centers for Disease Control and Prevention • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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New turkish diagnostic tool for carpal tunnel syndrome under study
Diagnosis CompletedThis study aims to translate and test a diagnostic tool called CTS-6 for Turkish-speaking patients with carpal tunnel syndrome. Researchers will enroll 126 adults, including healthy volunteers, people with symptoms, and those already diagnosed. The goal is to ensure the tool is a…
Sponsor: Istanbul University • Aim: Diagnosis
Last updated Aug 01, 2026 00:00 UTC
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Could a simple exam catch diabetic nerve damage early?
Diagnosis CompletedThis study tested two simple bedside tools—the Neuropathy Disability Score and Neuropathy Symptom Score—to screen for diabetic nerve damage. Researchers compared them to standard nerve tests in 228 adults with diabetes. The goal was to see if these easy-to-use tools could help de…
Sponsor: Chulalongkorn University • Aim: Diagnosis
Last updated Jun 27, 2026 12:24 UTC
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Laser test could objectively measure nerve pain for first time
Diagnosis CompletedThis study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…
Sponsor: University of Utah • Aim: Diagnosis
Last updated Jun 27, 2026 12:09 UTC
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Ultrasound may replace nerve tests for carpal tunnel diagnosis
Diagnosis CompletedThis study tested whether ultrasound can accurately diagnose mild to moderate carpal tunnel syndrome (CTS) by measuring the median nerve. Researchers compared ultrasound results with standard nerve tests and checked how they related to pain, symptoms, and quality of life in 75 pe…
Sponsor: Istanbul University • Aim: Diagnosis
Last updated Jun 27, 2026 09:04 UTC
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Could a common ED drug shield prostate cancer patients from chemo nerve pain?
Prevention CompletedThis study tested whether tadalafil, a drug often used for erectile dysfunction, can prevent nerve damage caused by docetaxel chemotherapy in men with metastatic prostate cancer. 90 participants were randomly assigned to receive either tadalafil plus standard care or standard car…
Phase 2 • Sponsor: Tri-Service General Hospital • Aim: Prevention
Last updated Jun 27, 2026 08:10 UTC
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Heartburn drug may shield cancer patients from nerve pain
Prevention CompletedThis study tested whether omeprazole, a common heartburn medication, could prevent nerve damage caused by oxaliplatin chemotherapy in 46 adults with colorectal or pancreatic cancer. Participants took omeprazole before and during chemotherapy cycles. The goal was to see if it redu…
Phase 3 • Sponsor: Aya Mohamed Sadek Elsaid • Aim: Prevention
Last updated Jun 26, 2026 15:11 UTC
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Electric pulses may bring back lost foot sensation in diabetes
Symptom relief CompletedDiabetic polyneuropathy damages nerves in the feet, dulling the sense of touch and raising the risk of unnoticed injuries. This trial tests whether transcutaneous electrical nerve stimulation (TENS) can restore that sensation. Researchers compare high-frequency TENS, low-frequenc…
Sponsor: Burdur Mehmet Akif Ersoy University • Aim: Symptom relief
Last updated Sep 21, 2026 22:00 UTC
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Cold therapy may offer relief for Chemotherapy-Induced nerve pain in children
Symptom relief CompletedThis study tests whether wearing cooling gloves and socks can reduce nerve pain and numbness in children aged 7 to 18 who are receiving vincristine chemotherapy for cancers like leukemia and Wilms tumor. The therapy uses adjustable gel packs that wrap around the hands and feet wi…
Sponsor: Koç University • Aim: Symptom relief
Last updated Sep 10, 2026 00:00 UTC
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Could music be medicine for the injured brain?
Symptom relief CompletedThis trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…
Sponsor: University College, London • Aim: Symptom relief
Last updated Aug 14, 2026 00:00 UTC
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New drug aims to ease chronic nerve pain from polyneuropathy
Symptom relief CompletedThis study tests a new drug called LY3848575 for people with long-term nerve pain starting in the feet and moving up the legs. About 558 participants will receive either the drug or a placebo to see if it safely reduces pain. The trial lasts up to 30 weeks and measures pain inten…
Phase 2 • Sponsor: Eli Lilly and Company • Aim: Symptom relief
Last updated Jul 12, 2026 00:00 UTC
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Could meditation and a simple device ease HIV nerve pain?
Symptom relief CompletedThis study explores whether combining mindfulness meditation with transcutaneous nerve stimulation (TENS) can reduce foot pain in people living with HIV who have peripheral neuropathy. Participants use a home TENS device and practice guided meditation over several weeks. The goal…
Sponsor: Rutgers University • Aim: Symptom relief
Last updated Jul 10, 2026 00:00 UTC
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Can a Nurse's hypnosis over video call ease nerve pain?
Symptom relief CompletedThis study tested whether hypnosis sessions led by a nurse over video call are practical for people with long-term nerve pain. Thirty adults with peripheral neuropathic pain for over a year took part. The goal was to see if patients would complete five sessions and if it helped w…
Sponsor: University Hospital, Bordeaux • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Common supplement may shield cancer patients from nerve pain
Symptom relief CompletedThis study tested whether taking N-Acetylcysteine before chemotherapy could reduce nerve damage in colorectal cancer patients receiving oxaliplatin. 46 participants received either N-Acetylcysteine or a placebo before each chemo session. The goal was to see if the supplement coul…
Sponsor: Tanta University • Aim: Symptom relief
Last updated Jun 27, 2026 09:03 UTC
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Squeeze away chemo fatigue? study tests sensory balls and relaxation for cancer patients
Symptom relief CompletedThis study tested whether nursing interventions based on the Levine Conservation Model could help colorectal cancer patients cope with fatigue, nerve damage, and anxiety caused by chemotherapy. 68 patients receiving the FOLFOX regimen were taught to use sensory balls, progressive…
Sponsor: KTO Karatay University • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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Hand exercises may reduce nerve stiffness in carpal tunnel patients
Symptom relief CompletedThis study looked at whether specific hand and wrist exercises could help people with mild to moderate carpal tunnel syndrome. 91 participants did either nerve gliding exercises or strengthening exercises daily for three weeks. The results suggest these exercises may reduce stiff…
Sponsor: University Medical Centre Ljubljana • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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Exercise and nutrition may ease chemo nerve damage
Symptom relief CompletedThis study looked at whether exercise or nutrition education can reduce nerve pain caused by chemotherapy in women with breast cancer. 80 women took part in a phase 2 trial comparing the two approaches. The goal was to see if these lifestyle changes could help manage symptoms and…
Phase 2 • Sponsor: University of Rochester • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Gene therapy shot aimed at diabetic nerve pain put to the test
Symptom relief CompletedThis study tested whether a gene therapy called VM202 could safely reduce pain in people with diabetic peripheral neuropathy. Over 500 adults with type 1 or type 2 diabetes received either VM202 injections or a placebo in their legs. The main goal was to see if the treatment lowe…
Phase 3 • Sponsor: Helixmith Co., Ltd. • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Vitamin b may shield ovarian cancer patients from chemo nerve damage
Symptom relief CompletedThis study looked at whether taking daily vitamin B complex can help prevent or reduce nerve pain (peripheral neuropathy) caused by the chemotherapy drug paclitaxel in women with ovarian cancer. 146 adult women took part. Half took vitamin B pills every day for 6 months while get…
Sponsor: National Cancer Institute, Egypt • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Can ultrasound spot early joint wear in diabetic nerve damage?
Knowledge-focused CompletedResearchers are using ultrasound to measure the thickness of ankle cartilage in people with type 2 diabetes who have nerve damage, and comparing it with healthy adults. Diabetic polyneuropathy may change how the lower limbs move, which could affect the ankle joint. The study incl…
Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital • Aim: Knowledge-focused
Last updated Sep 05, 2026 00:00 UTC
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Heat wave warning: study reveals how chronic illness patients suffer in high temperatures
Knowledge-focused CompletedThis completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…
Sponsor: Universitätsklinikum Hamburg-Eppendorf • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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New scoring system aims to detect chemo nerve damage earlier
Knowledge-focused CompletedThis study tested a simple, self-administered scoring system to identify moderate to severe nerve damage caused by chemotherapy in breast cancer survivors. 26 women who had taxane-based chemotherapy and radiation took part. The goal was to find the best score that separates those…
Sponsor: University Hospital Schleswig-Holstein • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:39 UTC
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Eye camera spots hidden inflammation in MS patients
Knowledge-focused CompletedThis study used a special eye camera (adaptive optics) to look at blood vessel inflammation in the retina of 50 people with multiple sclerosis (MS) and healthy volunteers. The goal was to see if this inflammation differs between MS types and could serve as an early marker of dise…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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Prosthetists may uncover silent health issues in amputees
Knowledge-focused CompletedThis study tested whether prosthetists—specialists who fit artificial limbs—can screen for common but often unnoticed health problems like depression, nerve damage, and poor blood flow in people who have had a leg amputation. Seventy participants were split into two groups: one r…
Sponsor: University of Delaware • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC