Perinatal asphyxia

This early study tests whether the drug theophylline can prevent kidney injury in newborns who experienced oxygen deprivation at birth (HIE) and are receiving cooling therapy. Thirty infants will receive one or two doses of theophylline within 18 hours of birth. The main goal is …

This study follows 25 people aged 2 to 65 with cerebral palsy or brain damage from lack of oxygen who have already received a new gene therapy given as a nose spray. The therapy delivers 15 genes meant to repair the brain, reduce inflammation, and improve movement and thinking. R…

This early-stage trial tests whether metformin, a common diabetes drug, is safe and feasible for infants who suffered brain injury from lack of oxygen at birth. Thirty infants under 6 months old will receive metformin for 6 weeks, with close monitoring of kidney and liver functio…

This study tests whether giving melatonin to full-term newborns with hypoxic-ischemic encephalopathy (HIE) — a type of brain injury from lack of oxygen at birth — can improve survival and reduce brain damage. Half of the 110 babies will receive a single dose of melatonin through …

This study tests whether giving the steroid hydrocortisone early, right when shock is diagnosed, helps very small preterm babies (under 1500 grams) recover faster. Researchers will compare babies who get standard shock treatment plus hydrocortisone to those who get standard treat…

This pilot study planned to give sildenafil (the drug in Viagra) to women in labor in low-resource areas, aiming to reduce fetal distress and birth asphyxia. It was designed to test whether the drug could be safely given and to gather data for a larger trial. However, the study w…

This pilot study aimed to see if giving sildenafil (the drug in Viagra) to women in labor could prevent fetal distress, reduce the need for emergency C-sections or forceps deliveries, and lower the risk of newborns needing breathing help. The trial planned to enroll 120 women in …

This study tests a 12-week digital group program called IMAGINE to see if it can prevent depression in pregnant people and new mothers who are at higher risk. About 100 participants will either join the online group or receive standard care. Researchers will check depression and …

This study tests a program called ROSE to see if it can prevent depression during pregnancy and after birth in people who experienced childhood adversity. About 76 pregnant individuals will either get the ROSE program or standard care. Researchers will track their mood with surve…

This study tests whether a digital sleep program (CBT-I) can prevent depression in pregnant people with insomnia. 456 participants will either use the CBT-I app or receive standard sleep hygiene education. Researchers will track who develops depression through one year after birt…

This study planned to test whether a mobile app-based training program could prevent or lessen mood disorders like depression and anxiety in pregnant women. It was designed for women with low-risk pregnancies who were not currently depressed. However, the study was withdrawn befo…

This study tests whether a 9-week online group therapy program (cognitive behavioural therapy) can help fathers and non-birthing parents who feel depressed during their partner's pregnancy or within the first 18 months after birth. About 48 participants in Ontario will be randoml…

This study tests a group prenatal care program called EleVATE GC for African-American women at high risk for postpartum depression. The program aims to reduce depression, preterm birth, and low birthweight by providing support and addressing stress. Researchers will compare outco…

This study tests a stepwise counseling model for pregnant women who screen positive for depression or anxiety. Participants are randomly assigned to either routine care or a program that starts with self-guided materials and, if needed, adds one-on-one sessions with an obstetrici…

This study tests a digital program that screens pregnant and postpartum women for depression using automated text message questionnaires. Results are linked to their electronic health records to help doctors identify those at risk and guide next steps. The goal is to see if this …

This study looks at how caffeine is processed in newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by lack of oxygen, who are receiving cooling therapy. Researchers will test different doses of caffeine in 16 babies to find the safest and most effective a…

This study is testing whether wireless, wearable sensors can safely and accurately monitor heart rate, breathing, temperature, and oxygen levels in 75 newborn babies in the NICU. The goal is to see if these wireless devices work as well as the standard wired monitors, and if they…

This study tests whether a culturally tailored mobile health program can improve mental health and pregnancy outcomes in Black pregnant women. Half of the 150 participants will receive the program, which builds communication and self-advocacy skills and provides support. The goal…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study is observing brain oxygen levels in two groups of newborns at high risk of brain injury: full-term babies undergoing cooling treatment for oxygen deprivation, and extremely premature babies. Researchers use a non-invasive light sensor (near-infrared spectroscopy) to me…

This study follows 30 infants with congenital heart disease who need heart surgery. Researchers will use blood tests, EEG brain wave monitoring, and MRI scans to look for signs of brain injury. The goal is to find better ways to detect brain damage early and identify which childr…

This study looks at over 3,400 newborns who are not vigorous at birth (between 35 and 42 weeks). Doctors want to see if milking the umbilical cord (pushing blood into the baby) before clamping it leads to fewer cases of brain injury or death compared to clamping the cord right aw…

This study is creating a database of medical information and biological samples (blood, urine, and cheek swabs) from 1,000 newborns with hypoxic-ischemic encephalopathy (HIE), a type of brain injury caused by lack of oxygen. The goal is to measure biomarkers in the blood that cou…

This study follows about 300 children who had seizures shortly after birth to see if their genes influence whether they develop epilepsy later in childhood. Researchers will combine genetic information with brain scans and EEG results to create a risk score. No new treatments are…

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…