Perinatal asphyxia

This study tests whether a 9-week online group cognitive behavioral therapy (CBT) program can reduce depression symptoms in fathers and fathers-to-be. Participants in Ontario who have depression symptoms during their partner's pregnancy or within the first 18 months after birth w…

This trial tests whether citicoline, a compound that may support brain cell repair, can improve outcomes in newborns with hypoxic-ischemic encephalopathy (HIE) — brain injury from oxygen deprivation at birth. About 86 infants with signs of birth asphyxia will receive either citic…

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This study tests whether adding melatonin to standard magnesium sulfate treatment improves recovery in full-term newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by oxygen deprivation at birth. Eighty babies will be split into two groups: one gets magnes…

Some newborns with HIE, a brain injury from lack of oxygen at birth, also develop heart problems. This pilot trial tests whether starting a heart medication called dobutamine early, before heart failure signs appear, is feasible and safe. Forty babies receiving cooling therapy wi…

This study tests whether infusing fluid into the uterus during labor (amnioinfusion) can reduce brain injury in newborns whose mothers have a uterine infection called chorioamnionitis. The infection can cause inflammation and fever that may stress the baby's brain before birth. R…

This phase 2 study will test how the drug sildenafil (Revatio) is processed in the bodies of 24 full-term newborns who experienced oxygen deprivation at birth and are already receiving standard cooling therapy. The goal is to measure drug levels and prepare for a larger trial tha…

This early-phase trial tests whether adding hydrogen gas to standard cooling therapy is safe and feasible for newborns who suffered brain injury from lack of oxygen at birth (HIE). About 54 infants will be randomly assigned to receive either standard cooling alone or cooling plus…

This study tests whether a computer algorithm can analyze standard EEG recordings from full-term newborns who experienced oxygen deprivation at birth to tell apart mild brain injury from moderate or severe forms. The algorithm's readings are compared against expert review of the …

This study tests whether the BIND score, a quick neurological check, can predict brain risk in newborns with severe jaundice. Researchers will use the score to guide phototherapy treatment in 80 infants under 28 days old. The goal is to catch and treat dangerous jaundice early, p…

This pilot study tests a digital program called Reaching Calm, designed to prevent anxiety in pregnant women at higher risk. The program sends text messages and provides web-based exercises to help women cope. Researchers will check if it's easy to use and if it reduces anxiety s…

This study tests whether combining a virtual reality forest experience with mindfulness practice can help reduce anxiety and depression in pregnant women. One hundred women between 20 and 24 weeks of pregnancy will either use VR forest sessions plus mindfulness or standard mindfu…

This study looks at whether gentle foot massage (reflexology) can improve comfort and vital signs in newborns with brain injury from oxygen loss, who are receiving cooling treatment. About 84 stable newborns will either get standard care or standard care plus foot reflexology. Re…

This study tests whether a 3-week bedside yoga program, added to standard depression treatment, can improve mother-infant bonding and reduce depression in new mothers. Fifty-two mothers with perinatal depression will be randomly assigned to yoga plus usual care or usual care alon…

This study tests a program called Center M, which offers weekly one-hour online group sessions led by a trained therapist. The goal is to see if it helps reduce symptoms of depression in pregnant people compared to standard care. About 160 participants will join, and their depres…

This study will compare two medicines, phenobarbital and levetiracetam, to see which is safer and more effective at stopping seizures in newborns with moderate to severe brain injury from lack of oxygen (HIE). The trial plans to enroll 66 infants and will measure how many become …

This pilot study will test whether live, improvised music therapy can lower pain levels in 22 newborns with hypoxic-ischemic encephalopathy (HIE) who are undergoing cooling therapy. Each baby will receive either standard care alone or standard care plus a 15-minute music session …

This pilot study is testing whether a wireless adhesive thermometer can safely and accurately monitor body temperature in newborns undergoing therapeutic hypothermia, a cooling treatment for brain injury. Currently, temperature is tracked with an invasive rectal probe, which carr…

This study is testing a program called Mothers and Babies for Down Syndrome (MBDS) to help prevent depression in new and expectant parents of infants with Down syndrome. About 72 parents will take part in a small pilot study to see if the program helps with feelings of grief and …

This study looks for early signs of brain injury in newborns who experienced oxygen deprivation at birth (perinatal asphyxia). Researchers will use EEG brain wave monitoring and eye-tracking tests, along with blood markers, to see if they can detect damage sooner than current met…

This study tests a more sensitive ultrasound method called speckle tracking echocardiography (STE) to check heart function in newborns. Researchers will scan healthy babies and those with conditions like lung disease or oxygen deprivation to establish normal values and track chan…

This study looks at whether a new method of interpreting fetal heart rate recordings (cardiotocography) can better identify when a baby is not getting enough oxygen during labor. Researchers will review data from 1,000 full-term pregnancies, combining past records and new enrollm…

This study tests whether a simulation-based training program for newborn care providers in Nepal can improve their skills in resuscitation and kangaroo mother care. The training uses a low-cost baby simulator and includes ongoing mentoring. Researchers will compare knowledge and …

This study looks at whether a protein called neurofilament light chain (NfL) in the blood can help measure brain injury in newborns with hypoxic-ischemic encephalopathy (HIE), a condition caused by lack of oxygen at birth. Researchers will measure NfL levels at several time point…

This study will enroll 50 people with severe brain injuries to see if combining different types of monitoring—like blood sugar levels, brain waves, and blood flow—can help predict how well they will recover. Researchers will follow participants for 6 months to check their neurolo…