Perinatal asphyxia

This study tested whether stem cells taken from a patient's own fat and given by IV are safe and might help the brain heal after a traumatic brain injury. 24 adults with long-term brain damage received the treatment. Researchers checked vital signs and measured inflammation marke…

This study tested the drug levetiracetam as the first treatment for seizures in 18 full-term newborns who had brain injury from lack of oxygen at birth. The goal was to find the right dose and check if it is safe and effective at reducing seizure activity on brain recordings. The…

This phase 3 study tested whether high doses of erythropoietin, a hormone that boosts red blood cell production, could improve survival and brain development in full-term newborns who suffered oxygen deprivation at birth. All 120 babies also received standard cooling therapy. The…

This study tested whether giving magnesium sulfate to full-term or near-term newborns with moderate to severe birth asphyxia could reduce death and brain damage. 178 infants were randomly assigned to receive either standard care or magnesium sulfate. Researchers tracked survival,…

This study looked at whether tiny molecules called microRNAs, found in the blood, can help diagnose brain injury in newborns who had a lack of oxygen at birth. Researchers measured microRNA levels in 45 newborns, including healthy babies and those with brain injury. The goal was …

This study tested a mobile app called Mamma Mia, designed to support mental health during pregnancy and after childbirth. Nearly 2,000 pregnant women used the app, which offers mindfulness exercises, breastfeeding tips, and relationship advice. Researchers measured changes in dep…

This study tested a sensorimotor program for infants with hypoxic-ischemic encephalopathy (HIE), a brain injury from lack of oxygen at birth. Eleven babies received play-based therapy sessions in the NICU and at home for the first 6 months. The goal was to see if the program was …

This study looked at whether a mother's scent and a soft, knitted octopus toy could reduce pain in newborns who had a lack of oxygen at birth (asphyxia) and were receiving cooling treatment. The study included 45 full-term babies in intensive care. Researchers measured pain level…

This study tested a drug called dexmedetomidine in 50 newborns with brain injury who were undergoing cooling therapy. The goal was to see if it could provide sedation and pain relief as well as morphine, but with fewer risks. Researchers measured safety and drug levels in the blo…

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This study tested a program where pregnant people could text with a trained peer mentor for support. 127 participants in Washington state were split into two groups: one could text a mentor, the other got automated messages. The mentor group had lower anxiety six weeks after givi…

This study tested whether an internet-based self-help mental fitness training camp could help prevent or reduce depression and anxiety in pregnant women. Over 1,600 women in early, mid, and late pregnancy took part, with some using the program and others receiving standard care. …

This completed pilot study tested a digital mental health platform called Center M for pregnant women with or at risk for perinatal depression. 116 participants were randomly assigned to either use the Center M app with telehealth mindfulness sessions and digital home practice, o…

This study tested a technology service to help care managers in obstetrics clinics treat depression during pregnancy and after birth. 75 women with moderate to severe depression used an app for symptom tracking and a website with educational content. The goal was to see if these …

This study looked at whether mothers can safely hold their infants while they undergo therapeutic hypothermia (cooling) for a brain injury called hypoxic-ischemic encephalopathy (HIE). Ten infants were enrolled, and mothers held them for 30 minutes under careful monitoring. The g…

This study tests whether a laryngeal mask airway (LMA) can be inserted during continuous chest compressions in a newborn resuscitation simulation. Standard guidelines recommend pausing compressions to insert an airway, but this interrupts blood flow. Thirty-two anesthesiologists …

This study looked at 31 full-term newborns with brain injury from lack of oxygen (hypoxic-ischemic encephalopathy). Researchers used a special MRI technique called arterial spin labeling to measure blood flow in the brain during the first week of life. The goal was to see if this…

This study looked back at the medical records of 168 adults who survived a cardiac arrest and were treated in the intensive care unit. Researchers wanted to find early signs that could predict which patients were more likely to die within 30 days or six months. By analyzing lab r…

This completed study in Nepal tested whether a 5-day simulation training program for birth attendants could improve their skills in managing newborn asphyxia. The training used a baby mannequin called NeoNatalie to practice resuscitation. Researchers compared the skills of health…

This study tested a new portable, wireless EEG monitor called NeuroBell on 17 full-term newborns who already needed brain monitoring. The goal was to see if the new device records brain signals as well as standard EEG machines. The study did not treat any condition, but aimed to …

This study looked at 29 children with brain injuries to test two new methods for checking how well the brain controls its own blood flow. The goal was to see if these methods could help doctors better understand and treat brain injuries. The study did not test a treatment, but ai…

This study followed 188 children who had seizures shortly after birth to see how they develop over time. Researchers measured thinking skills, behavior, and daily function. The goal is to understand which children are at higher risk for conditions like cerebral palsy or intellect…

This study tested a mobile app called Baby2Home designed to help new families get the healthcare they need after childbirth. Over 600 parents and their babies took part, with some using the app and others getting usual care. The goal was to see if the app improved checkups, vacci…

This study looked at how therapeutic hypothermia (cooling) affects the heart and brain blood flow in newborns who suffered oxygen loss at birth. Researchers used ultrasound to measure heart function and brain circulation in 113 babies. The goal was to better understand the body's…

This study tested a device called the Augmented Infant Resuscitator (AIR), which attaches to standard bag-mask ventilators used to help newborns breathe. It gives real-time visual feedback to clinicians on their ventilation technique. Researchers enrolled 250 birth attendants to …

This study tested a new, non-invasive device that uses light to measure a baby's oxygen levels through the mother's belly during labor. 35 women in labor participated. The device was used only for research and did not guide any medical decisions. The goal was to see if the device…

This pilot study tested whether a live video consultation between rural community hospitals and specialists at a larger center could help start cooling therapy faster for newborns with brain injury (neonatal encephalopathy). The study included 115 infants born in community hospit…