New trial aims to find best seizure treatment for Oxygen-Deprived newborns

NCT ID NCT07284498

Not yet recruiting Symptom relief Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will compare two medicines, phenobarbital and levetiracetam, to see which is safer and more effective at stopping seizures in newborns with moderate to severe brain injury from lack of oxygen (HIE). The trial plans to enroll 66 infants and will measure how many become seizure-free within 20-40 minutes of treatment. The goal is to improve care for these fragile newborns.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Phenobarbital and Levetiracetam
What this could lead to: If successful, this could show which drug works better and safer for stopping seizures in newborns with HIE, potentially improving outcomes.
What could go wrong: This is a small, early-phase trial with only 66 participants, so results may not apply broadly. Both drugs have known side effects, and the study hasn't started yet.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

perinatal asphyxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIE - HYPOXIC - ISCHEMIC ENCEPHALOPATHY NEONATAL SEIZURES

Contacts and locations

Locations

Al Galaa Teaching Hospital

Cairo, Egypt
University Children's Hospital, Mansoura University

Al Mansurah, Egypt

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