Could a common heart drug protect newborn brains? small trial launches
NCT ID NCT06810284
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 study will test how the drug sildenafil (Revatio) is processed in the bodies of 24 full-term newborns who experienced oxygen deprivation at birth and are already receiving standard cooling therapy. The goal is to measure drug levels and prepare for a larger trial that would check if adding sildenafil to cooling helps babies survive without brain damage. The study is not yet recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sildenafil citrate (Revatio)
- What this could lead to
- If successful, this could pave the way for a larger study testing whether combining sildenafil with cooling therapy helps newborns survive without brain damage after oxygen deprivation at birth.
- What could go wrong
- This is a very early, small study (24 babies) focused only on drug levels, not on whether the treatment actually works. The drug may not improve outcomes or could cause side effects in fragile newborns.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Unité de Recherche Clinique, Entrepôts de données et Pharmacologie GHU Paris Centre
Paris, 75005, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Brain-Wave algorithm may flag newborns needing urgent cooling
- A glowing clue: light sensor may spot kidney damage in newborns
- Early therapy may rewire motor development in premature infants
- Could a wireless patch replace wires on tiny heads? a NICU trial puts it to the test
- Simple cord milking procedure could protect newborn brains after difficult births
- AI camera watches newborns' brains—no wires, no touch