Parathyroid gland disorder

This study tests a 5-week community-based program that teaches protective behavioral strategies to reduce alcohol use in men aged 35–44 with hazardous drinking habits in rural Vietnam. Participants learn to set safe drinking limits, choose nonalcoholic drinks, and plan ahead, wit…

This study tested the safety of combining two drugs, alpelisib and fulvestrant, in 40 men and post-menopausal women with a certain type of advanced breast cancer (HR+, HER2-, with a PIK3CA mutation) that had worsened after hormone therapy. The goal was to track side effects. The …

This large study tested whether evolocumab (Repatha), a cholesterol-lowering injection, could reduce major cardiovascular events like heart attacks, strokes, or death in over 12,000 adults at high risk but without a prior heart attack or stroke. Participants received either evolo…

This phase 2 trial tested a daily injection called TransCon PTH in 59 adults with hypoparathyroidism, a condition where the body doesn't make enough parathyroid hormone. Participants were randomly assigned to receive either the drug or a placebo for four weeks, followed by an ope…

This study tests a new drug called SHR6508 in 303 adults on hemodialysis who have secondary hyperparathyroidism, a condition where parathyroid hormone levels get too high. The drug is given as an injection to help control these hormone levels and related minerals like calcium and…

This study looked at whether surgery helps people over 65 with mild primary hyperparathyroidism (high calcium levels) compared to just monitoring them. The goal was to see if surgery improves bone density and lowers fracture risk. A total of 102 participants were randomly assigne…

This study tested a new medicine called MBX 2109, given once a week as a shot, in 64 adults with hypoparathyroidism. The goal was to see if it could safely help patients reduce their daily calcium and vitamin D pills while keeping blood calcium levels normal. The trial was comple…

This study tested a drug called encaleret in 13 adults with post-surgical hypoparathyroidism, a condition where damaged parathyroid glands cause low blood calcium. Participants took the drug for 5 days while staying in the clinic, with frequent blood and urine tests. The goal was…

This study tested two ways of delivering synthetic parathyroid hormone (PTH) to people with chronic hypoparathyroidism, a condition where the body doesn't make enough PTH, causing low calcium. Researchers compared using an insulin pump to give steady, small doses versus twice-dai…

This Phase 3 trial tested a daily injection of TransCon PTH, a synthetic parathyroid hormone, in 84 adults with hypoparathyroidism. The goal was to see if it could help patients maintain normal blood calcium levels while reducing their need for high-dose calcium and vitamin D sup…

This study tested a new drug called MT1013 in 115 adults with chronic kidney disease who are on dialysis and have a condition called secondary hyperparathyroidism (high parathyroid hormone). The goal was to see if the drug could safely lower hormone levels by at least 30%. Partic…

This study tested a new drug called MT1013 in 98 adults on kidney dialysis who have secondary hyperparathyroidism, a condition where parathyroid hormone levels are too high. The goal was to see if the drug is safe and can lower these hormone levels. Participants received either t…

This study tested a new drug, palopegteriparatide, in 90 adults with chronic hypoparathyroidism. The goal was to see if the drug could help patients stop taking activated vitamin D and calcium supplements for at least four weeks. Researchers tracked how long it took to become sup…

This study tested a daily injection called TransCon PTH in 81 adults with hypoparathyroidism, a condition where the body lacks parathyroid hormone, causing low calcium levels. The goal was to see if the drug could bring calcium levels back to normal and allow patients to stop tak…

This study tested a new drug called SHR6508 in 498 adults on hemodialysis who have secondary hyperparathyroidism, a condition where the parathyroid glands make too much hormone. The drug is given during dialysis and was compared to an existing oral medication, cinacalcet. The goa…

This study tested whether a daily oral pill can safely and temporarily lower sperm counts in healthy men to prevent pregnancy. Ninety-two men took either the experimental drug (DMAU) alone, DMAU plus another hormone (LNG), or a placebo for 12 weeks. The goal was to see if sperm c…

This early-stage trial tested a synthetic parathyroid hormone analog called AZP-3601 in healthy volunteers and patients with chronic hypoparathyroidism, a condition where the body doesn't produce enough parathyroid hormone. The study aimed to check safety and how the drug works i…

This study tested a drug called PLS240 in 412 adults with end-stage kidney disease on dialysis who also have overactive parathyroid glands (secondary hyperparathyroidism). Participants received either PLS240 or a placebo intravenously three times a week for 27 weeks, followed by …

This study tested a drug called PLS240 in 362 adults with end-stage kidney disease on dialysis who also have overactive parathyroid glands (secondary hyperparathyroidism). Participants received either PLS240 or a placebo during dialysis three times a week for 27 weeks, followed b…

This study tested a special PET scan (18F-fluorocholine) to see if it could better locate overactive parathyroid glands (adenomas) in people with hyperparathyroidism. 139 participants received the scan before surgery, and the results were compared to standard imaging and the actu…

This pilot study tested a virtual program designed to help older men at high risk for fractures reduce their risk of falls and broken bones. The program included personalized exercise plans delivered through a smartphone app and virtual nutrition counseling. Researchers enrolled …

This study tested whether spraying a blue dye called methylene blue onto tissues during thyroid surgery helps surgeons better see and protect the nerve that controls voice and the glands that regulate calcium. 136 adults with benign thyroid nodules took part. The goal was to redu…

This study tested a device called PTeye that uses near-infrared light to help surgeons spot parathyroid glands during surgery for hyperparathyroidism. The goal was to see if it could reduce the number of tissue samples sent to the lab and lower the risk of needing a second surger…

This study looked at 300 patients who had their thyroid removed to see if a parathyroid hormone (PTH) test right after surgery could predict low calcium levels. The goal was to find a threshold that rules out hypoparathyroidism. Researchers reviewed past medical records to analyz…

This study compared two methods for measuring bioavailable testosterone in the blood: the standard lab test (radioimmunoassay) and a mathematical calculation. Researchers included 270 men and women aged 18 to 90. The goal was to see if the calculation matches the lab test closely…

This completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…

This study tests whether a single dose of the drug cinacalcet can be used to measure how well the body suppresses parathyroid hormone (PTH). Researchers compare this pill-based test to the standard intravenous calcium test in healthy adults, and also compare results between healt…

This completed study brought together men who have had suicidal thoughts to help design suicide prevention tools. Over up to 10 meetings, 13 men gave feedback on tool drafts, focusing on usability, privacy, and support. The goal was to create resources that truly fit their needs.

This completed Phase 1 study looked at how a radioactive form of the drug SHR6508 is processed and eliminated in 5 Chinese adults on hemodialysis who have secondary hyperparathyroidism. The main goal was to measure how much radioactivity ends up in urine and stool, and to identif…

This early-stage study tested several new oral tablet versions of a bone-building hormone (hPTH 1-34) in 45 healthy men aged 18-35. The goal was to see how well the body absorbs these new tablets compared to an existing oral tablet and a standard daily injection. Researchers meas…

This study checked how well patients and doctors understand the risks and safe use of NATPARA, a drug for hypoparathyroidism. About 200 people took a survey online, by phone, or on paper. No medicine was given—the goal was just to measure knowledge and attitudes.

This study tested whether using ultrasound as the first imaging step before parathyroid surgery can safely reduce the need for radiation-based scans. 99 adults with primary hyperparathyroidism were enrolled. Those with clear ultrasound results went straight to surgery; others had…

This study looked at the genetic makeup of 29 people with APECED syndrome, a rare autoimmune disorder. Researchers aimed to find common gene mutations and link them to symptoms. The goal was to better understand the disease and improve diagnosis.

This study looked at 167 adults with chronic kidney disease on either hemodialysis or peritoneal dialysis to compare their blood levels of calcium, phosphorus, and other minerals linked to bone health. The goal was to see if one dialysis method is associated with fewer mineral an…

This completed study of 123 patients looked at what factors predict low calcium levels after total thyroid removal. Researchers measured calcium and parathyroid hormone (PTH) levels before and after surgery. They found that a low PTH level after surgery is a strong warning sign f…