Mitral valve disorder

This trial tests whether doctors using mixed reality goggles (HoloLens 2.0) can perform MitraClip heart valve repair more efficiently and with less stress. Twenty adults with leaky mitral valves will undergo the standard clip procedure, but the surgeon will also wear a headset th…

This trial tests a new replacement heart valve, the Neovasc Tiara, that is delivered through a small tube (catheter) inserted into the chest. It is designed for people with severe mitral regurgitation—a leaky heart valve—who are too high-risk for traditional open-heart surgery. T…

This study tested whether adding sacubitril-valsartan to standard care helps people with heart failure (with preserved pumping ability) and a leaky mitral valve. 84 participants were randomly assigned to get the drug or standard care alone. Researchers measured heart function and…

This completed study in 180 heart failure patients compared the effects of taking Entresto alone versus Entresto plus a second drug (empagliflozin) on mitral valve function and heart pumping ability. Participants had heart failure with reduced ejection fraction and some degree of…

This study tested whether a new way of processing tissue for Edwards heart valves is safe and works well. 777 adults who needed a new aortic or mitral valve took part. Researchers checked for valve problems like wear or calcification over about a year, and will follow patients fo…

This study tested whether it is safe and feasible to perform two heart procedures—MitraClip to repair a leaky mitral valve and Watchman to close off a part of the heart linked to stroke risk—in one session. The trial enrolled 25 adults with both severe mitral regurgitation and at…

This early study tested a new, less invasive procedure to treat functional mitral regurgitation, a condition where a leaky heart valve causes heart failure symptoms like shortness of breath and fatigue. Nineteen adults with this condition received a permanently implanted device t…

This study tested whether a left stellate ganglion block, given before mitral valve replacement, could protect the heart muscle. 62 adults undergoing elective on-pump mitral valve replacement received either a saline placebo or bupivacaine nerve block. Researchers checked for mic…

This study tested a new device called the Edwards PASCAL system, which repairs leaky mitral heart valves using a thin tube inserted through a blood vessel, avoiding open-heart surgery. It involved 124 adults with moderate-to-severe mitral regurgitation who were candidates for sur…

This study tested whether using a measure of oxygen in the blood (SvO2) to guide red blood cell transfusions during heart surgery could reduce how many patients receive transfusions. Over 600 adults undergoing on-pump cardiac surgery were randomly assigned to either standard rest…

This study tested the MitraClip device in 51 people in China with a leaky heart valve (mitral regurgitation). The device is inserted through a vein in the leg and clips the valve to reduce leakage. The goal was to see if the procedure is safe and effective, with recovery typicall…

This study tested a device called MitraClip in 162 heart failure patients with a leaky mitral valve (mitral regurgitation). The device is clipped onto the valve to reduce leakage. The goal was to see if it is safe and effective in real-world conditions. All patients had severe sy…

This study tested a new device called the Tiara valve, which is implanted through a small tube in the chest to replace the leaky mitral valve without open-heart surgery. It enrolled 157 people with severe mitral regurgitation who were considered too high-risk for traditional surg…

This study tested a device called MitraClip, which is a small clip placed through a tube in a vein to repair a leaky mitral valve in the heart. The trial included 304 people with severe mitral regurgitation and heart failure. Half got the clip plus standard medical care, and half…

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This study tested whether a computerized stethoscope that uses artificial intelligence (AI) can accurately detect two common heart valve conditions: aortic stenosis and mitral regurgitation. Researchers at Mayo Clinic recorded heart sounds from 400 adults and compared the AI's an…

This study looked at two types of exercise training—moderate-intensity interval training and continuous training—in 56 adults aged 40-60 who had mitral valve replacement surgery 4-8 weeks earlier. Over 12 weeks, researchers measured walking ability, lung function, heart efficienc…

This study tested whether virtual reality relaxation or binaural beat stimulation can improve sleep and reduce discomfort in 140 adults who had mechanical heart valve replacement. Many patients struggle with sleep due to the sound of the new valve. Participants were randomly assi…

This study tested whether freezing certain nerves in the chest (cryoablation) can reduce pain and the need for strong painkillers after minimally invasive mitral valve surgery. Thirty adults took part, and researchers measured pain levels and opioid use. The goal was to gather ea…

This study looked at whether using a Passy-Muir valve (a small device that helps people with a tracheostomy speak) can also improve how far they can walk. 26 adults with a tracheostomy completed several 6-minute walk tests, alternating between using the valve and leaving the trac…

This study tested whether a virtual reality (VR) experience could reduce anxiety in 75 patients scheduled for a heart valve repair procedure called TEER. Patients either got standard education or standard education plus a VR tour of the procedure and hospital. The researchers mea…

This study looked at whether having a nurse talk with patients before and after a heart valve procedure could improve care. About 194 people took part. The nurses helped prepare patients and checked on them afterward, either by phone or in person. The goal was to see if this extr…

This study tested whether a nerve block (serratus anterior plane block) can reduce pain and the need for strong painkillers after minimally invasive mitral valve repair. 78 adults having this heart surgery were randomly assigned to receive either the nerve block or a placebo. The…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

This study tests whether wearing a heart monitor for 14 days can detect dangerous heart rhythms in people with mitral valve prolapse (a common heart valve condition) better than the usual 24-hour test. About 60 adults with MVP will wear a patch monitor for two weeks. The goal is …

This study looks at how well the Melody valve holds up when used to replace the mitral or tricuspid heart valves. Researchers will review medical records from patients who had this valve surgically placed before December 2014. They will measure valve function, any narrowing or le…

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This study looked at 1,811 patients aged 60-70 who had heart valve replacement surgery. Researchers compared different types of artificial valves to see if the valve type was linked to developing depression, anxiety, or sleep disorders later. The goal was to understand if the cho…

This completed study used artificial intelligence to analyze electrocardiograms (ECGs) and chest X-rays from over 116,000 adults. The goal was to see if combining these routine tests could predict which patients would develop moderate or severe heart valve regurgitation. The rese…

This study looked at 140 adults having mitral valve surgery to see if a special heart ultrasound measure (called global longitudinal strain) could predict a serious complication called low cardiac output syndrome. Researchers checked ultrasound images taken during surgery and tra…

This study looked at 54 people with severe mitral regurgitation who received the MitraClip device. Researchers used heart MRI and ultrasound before, right after, and 6 months after the procedure to see how the heart's shape and function changed. The goal was to understand the hea…

This study looked at 80 adults having heart valve or aortic surgery to find out how long a special heart protection solution (Del Nido cardioplegia) keeps the heart safe during surgery. Researchers took blood samples at set times to see when heart injury began. The goal was to le…

This study looked at 60 heart surgery patients to see how two different bypass machines affect blood flow in tiny vessels under the tongue. One method was minimally invasive, the other was the standard approach. The goal was to find out which technique keeps small blood vessels w…

This study tested whether automated alerts in electronic health records help doctors identify and treat patients with severe aortic stenosis or mitral regurgitation. Over 2,100 patients were included, and some doctors received alerts while others did not. The goal was to see if a…

This study collected information from multiple hospitals on the Cor-Knot® device, which automatically ties knots during heart valve surgery. The goal was to see how safe and effective it is. Over 550 adults having planned valve surgery took part. The main focus was on whether lea…

This study looked at 4,000 adults who had a heart MRI to find out how often a small heart valve variation called mitral annular disjunction (MAD) occurs. Researchers wanted to see if MAD is linked to heart valve problems or dangerous heart rhythms. The goal was to better understa…

This study looked at how spinal anesthesia changes blood flow and heart function in 44 patients with severe aortic stenosis or mitral regurgitation during valve replacement surgery. Researchers measured the need for drugs that support blood pressure and heart function, as well as…

This study tested a computer program called naevia medical that helps doctors decide the best treatment for heart valve disease. Researchers looked at 106 past patient cases to see if the tool gave better recommendations than usual care. The goal was to see if the tool could redu…

This completed study followed 427 children under 14 who had surgery for mitral regurgitation (a leaky heart valve) at eight hospitals in China. Researchers compared two surgical repair strategies to see which led to better outcomes, like survival and avoiding repeat surgery. The …

This study looked at over 3,500 patients aged 70 or younger who had mitral valve replacement surgery in Austria between 2010 and 2020. Researchers compared those who got a mechanical valve versus a biological valve to see which group lived longer and needed fewer repeat operation…