Nerve block before heart surgery may shield muscle from damage

NCT ID NCT06476925

Completed Disease control Sponsor: Minia University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a left stellate ganglion block, given before mitral valve replacement, could protect the heart muscle. 62 adults undergoing elective on-pump mitral valve replacement received either a saline placebo or bupivacaine nerve block. Researchers checked for microscopic heart muscle injury, arrhythmias, and troponin levels. The goal is to see if this simple procedure can reduce damage and improve recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bupivacaine
What this could lead to: If it works, this could lead to a simple procedure that reduces heart muscle damage and irregular heartbeats after mitral valve replacement.
What could go wrong: This is a small, single-center study with only 62 participants. The results may not apply to all heart surgery patients, and nerve blocks carry risks like bleeding or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

mitral valve disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPEN MITRAL CARDIAC SURGERY

Contacts and locations

Locations

Mina Raouf

Minya, Minya Governorate, 61511, Egypt

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