Heart valve clip could cut hospital visits for heart failure patients

NCT ID NCT01920698

Completed Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a device called MitraClip, which is a small clip placed through a tube in a vein to repair a leaky mitral valve in the heart. The trial included 304 people with severe mitral regurgitation and heart failure. Half got the clip plus standard medical care, and half got standard care alone. Researchers tracked deaths and unplanned hospital stays for heart failure over two years to see if the clip helped.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MitraClip device (a clip implanted via catheter to repair the mitral valve)
What this could lead to: If successful, this could provide a less invasive treatment option for people with severe mitral regurgitation, potentially reducing deaths and hospital stays.
What could go wrong: This is a completed trial, but results may not apply to all patients. The procedure carries risks like bleeding, infection, or valve damage, and may not work for everyone.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder heart disorder heart failure heart valve disorder mitral valve insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASES

Contacts and locations

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Locations

APHP Hôpital Henri Mondor

Créteil, France
Aphp Hopital Bichat

Paris, France
CH Annecy Genevois

Metz-Tessy, 74370, France
CHRU La Cavale Blanche

Brest, France
CHRU La Milétrie

Poitiers, France
CHRU de Tours

Tours, France
CHU Caen

Caen, 14000, France
CHU Rouen

Rouen, France
CHU d'Angers

Angers, 49933, France
CHU de Grenoble

Grenoble, 38700, France
Centre Cardiologique du Nord

Saint-Denis, France
Centre Chirurgical Marie Lannelongue

Le Plessis-Robinson, France
Centre chirurgicale Ambroise Paré

Neuilly-sur-Seine, 92200, France
Chu de Besancon

Besançon, France
Chu de Bordeaux

Bordeaux, France
Chu de Lille

Lille, France
Chu de Montpellier

Montpellier, France
Chu de Nancy

Nancy, France
Chu de Nantes

Nantes, France
Chu de Rennes

Rennes, France
Chu de Strasbourg

Strasbourg, France
Chu de Toulouse

Toulouse, France
Clinique Cardiologique Saint Gatien

Tours, France
Clinique Du Millenaire

Montpellier, France
Clinique Pasteur

Toulouse, 31076, France
Clinique du Tonkin

Villeurbanne, France
Groupe Hospitalier La Salpétrière

Paris, 75013, France
Groupement Hospitalier Est

Bron, France
Hopital de La Timone

Marseille, France
Hôpital Européen Georges Pompidou

Paris, 75015, France
Hôpital Gabriel Montpied

Clermont-Ferrand, 63000, France
Hôpital Nord

Saint-Etienne, 42055, France
Hôpital Pasteur

Nice, 06001, France
Hôpital Saint-Joseph

Marseille, 13285, France
Hôpital privé Clairval

Marseille, France
Hôpital privé de Parly 2

Le Chesnay, 78150, France
Hôpital privé le Bois

Lille, France
Institut Arnault Tzanck

Saint-Laurent-du-Var, France
Institut Hospitalier Jacques Cartier

Massy, France
Institut Mutualiste Montsouris

Paris, 75014, France

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