Rheumatic disease of mitral valve

This study compares aspirin to the blood thinner warfarin in 1058 people who just had a bioprosthetic heart valve replacement. For 6 months after surgery, participants take either daily aspirin or warfarin. The goal is to see if aspirin is just as safe and effective at preventing…

This study is testing a new type of biological heart valve that features an 'easy change' system, designed to make future replacements simpler. Researchers will implant these valves in 500 people with aortic valve disease and track complications like blood clots, infections, and …

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study tests a home-based cardiac rehabilitation program delivered through a custom app for people who have had a heart valve procedure. Participants who choose not to attend center-based rehab are randomly assigned to usual care, the app with self-guided content, or the app …

This study is testing a new artificial heart valve (MITRIS RESILIA) in 250 Chinese patients who need their mitral valve replaced. The goal is to see how safe and well the valve works over time by measuring blood flow and leaks. Participants must be 18 or older and willing to foll…

This study looks at whether a special 3D ultrasound technique called TrueVue can better find and measure calcium buildup on the mitral valve, a common heart problem. Researchers will compare the ultrasound images to CT scans in 100 adults who already need these tests. If successf…

This study tests an artificial intelligence (AI) model that can screen for heart valve disease using standard chest CT scans that people already get for other reasons. The goal is to see how well the AI catches moderate-to-severe cases without needing extra tests or contrast dye.…

This study tests whether a portable electronic stethoscope, combined with machine learning, can accurately detect valvular heart disease. About 125 people with and without the condition will use the device and also receive standard heart tests. Researchers will compare the device…

This study is testing whether having a dental checkup before heart valve surgery can prevent serious complications like infection of the heart lining, repeat surgery, or death. About 1,300 adults scheduled for valve surgery will be randomly assigned to either get a dental screeni…

This registry will follow 2,500 people who receive Abbott heart devices, such as implants for holes in the heart or replacement heart valves. The goal is to check how safe and effective these devices are when used in everyday hospital practice. Data will be collected from standar…

This study at Mayo Clinic looks at how changes in the blood vessels of the lungs affect people with heart valve disease. Researchers will use echocardiograms during routine heart catheterization to measure these changes in 600 adults scheduled for valve procedures. The goal is to…

This study follows 500 adults with severe mitral valve disease who are not candidates for surgery. Researchers will track deaths and heart-related hospitalizations over two years to understand how these patients fare. The goal is to gather real-world data to help doctors make bet…

This study tests whether artificial intelligence (AI) can help cardiologists read echocardiograms (heart ultrasounds) more quickly and consistently. Researchers will give AI analysis to doctors in real time as they review heart images from 50 participants with valve disease. The …

This study is a registry that will follow up to 2,700 people who have received or will receive a Medtronic heart valve product during surgery. The goal is to monitor the long-term safety and performance of these devices by identifying any unexpected problems or trends. Participan…

This study is looking at how well the Mosaic mitral heart valve works over time in people under 65. Researchers will review medical records of 300 patients who had this valve placed at ProMedica Toledo Hospital. The goal is to understand survival rates, valve stability, and the n…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study looks at whether a special heart ultrasound measurement, called global longitudinal strain (GLS), can predict if a person will have trouble coming off the heart-lung machine during heart surgery. About 213 adults having planned heart surgery will have their hearts meas…

This study uses artificial intelligence to analyze data from 21,000 patients who had heart valve procedures. The goal is to make AI tools that can predict surgery outcomes, like which device to use and risks of complications, with over 90% accuracy. This is a non-interventional s…

This registry will track 800 adults with valvular heart disease to see if women and men receive different diagnosis, treatment, and follow-up care. Researchers will compare how quickly each group gets guideline-recommended therapies and whether gender, age, or ethnicity affect ou…

This study looks at whether common blood tests for heart damage (troponin and CK-MB) match what an MRI shows after heart valve surgery. Researchers will enroll 100 adults having aortic or mitral valve surgery. The goal is to improve how heart attacks are diagnosed after surgery, …

This study is following 4,000 people with heart valve disease to look for new substances in the body (called metabolites) that might be linked to the disease. Researchers hope to find better ways to predict who will get worse and understand why. No new treatments are being tested…